Treating Youths With PTSD and Conduct Problems

治疗患有创伤后应激障碍和行为问题的青少年

• 批准号: 7470664
• 负责人: DANA K SMITH
• 金额: $ 15.26万
• 依托单位: OSLC COMMUNITY PROGRAMS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-19 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470664
• 关键词: Alcohol or Other Drugs use; Anxiety; Area; Award; Chronic; Clinical Research; Complement; Conduct Clinical Trials; Development; Female; Funding; Goals; Institutionalization; Instruction; Intervention; Intervention Studies; Intervention Trial; K-Series Research Career Programs; Knowledge; Measures; Mental Depression; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Outcome; Phase; Post-Traumatic Stress Disorders; Problem behavior; Protocols documentation; Purpose; Rate; Recording of previous events; Research; Research Proposals; Review, Systematic (PT); Risk; Runaway Behavior; Sampling; Schools; Sex Behavior; Sleep; Specific qualifier value; Symptoms; Testing; Training; Training Activity; Trauma; Treatment Protocols; Youth; design; experience; girls; programs; size; skills; therapy development

DESCRIPTION (provided by applicant): The applicant is requesting 5 years of funding through the Mentored Career Development Award (K23) program to enhance her skills and knowledge in intervention research methodology with the ultimate goal of developing an independent program of research. The purpose of this award is to allow the applicant to build on her previous clinical and research experience indicating that female youths who have conduct problems have high rates of PTSD symptoms, which complicate treatment efforts. Specifically, the proposed training goals will provide specialized instruction and mentoring in the following areas: (1) the conduct of clinical trials, (2) intervention development for the integrated treatment of comorbid PTSD symptoms and conduct problems, (3) advanced statistical training in topics central to intervention research, and (4) training in the ethical conduct of research. The research plan is divided into three phases which complement the proposed sequence of training activities. During Phase I, the applicant will conduct a systematic review of existing assessments and interventions for treating PTSD. Under the guidance of mentors, assessments and interventions will be adapted for the treatment of PTSD symptoms with female youths who have comorbid conduct problems. During Phase II, the feasibility of the integrated intervention protocol will be tested on a small sample of female youths with comorbid PTSD symptoms and conduct problems. During Phase III, a small-scale pilot intervention trial will be conducted to test the integrated intervention protocol with a sample of female youths with comorbid PTSD symptoms and conduct problems. Each phase will build on previous phases, with the goal of producing a repeated assessment and an integrated intervention protocol for the treatment of PTSD symptoms in female youths who have comorbid conduct problems. Findings from the proposed research will be used to provide an effect-size estimate for the integrated treatment of comorbid PTSD symptoms and conduct problems, and ultimately, will provide the applicant with the knowledge and experience to pursue subsequent R01 applications and to expand this research to larger, more diverse samples.

描述（由申请人提供）：申请人通过“指导职业发展奖”（K23）计划要求提供5年的资金，以增强她在干预研究方法中的技能和知识，以实现开发独立研究计划的最终目标。该奖项的目的是允许申请人建立在她以前的临床和研究经验的基础上，表明有问题的女性青年患有很高的PTSD症状，这使治疗工作变得复杂。具体而言，拟议的培训目标将在以下领域提供专门的指导和指导：（1）进行临床试验的进行，（2）开发合并症PTSD症状的综合治疗，并进行问题，（3）主题中的高级统计培训中心的干预研究中心的统计培训，以及（4）研究的伦理学培训。研究计划分为三个阶段，这些阶段补充了提议的培训活动序列。在第一阶段，申请人将对治疗PTSD的现有评估和干预措施进行系统的审查。在导师的指导下，评估和干预措施将适用于与患有合并症的女性青年对PTSD症状的治疗。在II阶段期间，将对具有合并症PTSD症状的一小部分女性青年样本进行测试，并进行问题。在第三阶段期间，将进行小规模的试点干预试验，以测试具有合并症PTSD症状的女性青年样本并进行问题的综合干预方案。每个阶段都将基于先前的阶段，目的是进行重复评估和综合干预方案，以治疗患有合并性行为问题的女性青年的PTSD症状。拟议研究的结果将用于提供效应大小的估计，以综合处理PTSD症状并进行问题，最终将为申请人提供知识和经验，以追求随后的R01应用程序，并将这项研究扩展到更大，更多样化的样本。