PHS 2018-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Gra

PHS 2018-02 NIH、CDC 和 FDA 小型企业创新研究综合征集

• 批准号: 9907813
• 负责人: DANA K SMITH
• 金额: $ 22.5万
• 依托单位: OREGON RES BEHAVIORAL INTERVENTION STRAT
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-30 至 2020-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9907813
• 关键词: PHS; 2018; 02; Omnibus; Solicitation

Abstract Despite overall declines in the rate of tobacco use in the United States over the past 30 years, nearly 38 million Americans still smoke, posing extremely high risk for long-term health problems and death. There has been extensive research evaluating a wide range of smoking cessation approaches over the past 40 years. Recent reviews note that there has been significant progress in the application of both clinical and public health interventions to help smokers quit; however, they have also concluded that the overall success rate of smokers quitting has not significantly improved. Individual, group and public health interventions – both with and without adjunctive aids such as nicotine replacement therapy – have generally used some combination of cognitive-behavioral interventions, but there remains a need for novel, theory-driven approaches to enhance quit rates and innovative interventions that increase reach and engagement, such as those offered via computer or mobile app. We propose to adapt and test the feasibility of a previously piloted cognitive dissonance intervention (CDI) for smoking cessation that will be delivered via a mobile app. Cognitive dissonance interventions have been shown to be successful in treating health-related problems, as well as substance use, and preliminary findings support its use in smoking cessation. The program will be evaluated with 60 adult daily smokers and will be the only cognitive dissonance mobile app for smoking cessation. Our research and development team has extensive experience developing and testing mobile apps and developing and testing cognitive dissonance and smoking cessation interventions. In the first phase, we will use an iterative development plan to design and develop functionality of the first 3 modules of the CDI prototype app. The research team will partner with Twenty Ideas who have extensive experience in the development of mobile apps for smartphones, many of which have been commercialized. We will assess navigation and usability with adult daily smokers. Additional pilot testing will be used to create a prototype version for evaluation. The evaluation study will involve having 60 adults use the app and complete baseline, 1- and 3-month follow-up. Usability data, system log data on program use, and participant satisfaction data will also be analyzed. Input from participants will be gathered to incorporate additional features to be developed during Phase II. Significant changes in quit attempts, number of days without smoking (smokefree days) and changes in smoking attitudes and behavior will be used to determine the efficacy of the Phase I program and evidence for proceeding to Phase II development and evaluation.

抽象的 尽管过去 30 年美国的烟草使用率总体下降，但近 3800 万美国人仍然吸烟，造成长期健康问题和死亡的风险极高。那里 过去 40 年来进行了广泛的研究，评估了各种戒烟方法 年。最近的评论指出，临床和公共应用方面都取得了重大进展。 帮助吸烟者戒烟的健康干预措施；然而，他们还得出结论，总体成功率 吸烟者的戒烟情况并没有明显改善。个人、团体和公共卫生干预措施——两者都包括 并且在没有尼古丁替代疗法等辅助治疗的情况下，通常使用某种组合 认知行为干预措施，但仍然需要新颖的、理论驱动的方法来增强 戒烟率和创新干预措施可以提高影响力和参与度，例如通过 电脑或移动应用程序。我们建议调整并测试先前试点的认知的可行性 将通过移动应用程序提供戒烟失调干预（CDI）。认知的 失调干预措施已被证明可以成功地治疗与健康相关的问题，以及 物质使用，初步研究结果支持其用于戒烟。该计划将被评估 与 60 名成年每日吸烟者合作，将成为唯一一款用于戒烟的认知失调移动应用程序。我们的 研发团队拥有丰富的移动应用程序开发和测试经验 并测试认知失调和戒烟干预措施。在第一阶段，我们将使用 迭代开发计划，设计和开发 CDI 原型应用程序前 3 个模块的功能。 研究团队将与在移动开发方面拥有丰富经验的“二十创意”(Twenty Ideas) 合作。 智能手机应用程序，其中许多已经商业化。我们将评估导航和可用性 成年每日吸烟者。额外的试点测试将用于创建用于评估的原型版本。这 评估研究将让 60 名成年人使用该应用程序并完成基线、1 个月和 3 个月的随访。 可用性数据、程序使用的系统日志数据以及参与者满意度数据也将被分析。输入 将收集参与者的意见，以纳入第二阶段开发的附加功能。重要的 戒烟尝试的变化、不吸烟天数（无烟天数）以及吸烟态度的变化 和行为将用于确定第一阶段计划的有效性和继续进行的证据 第二阶段开发和评估。