SPF BREEDING COLONIES AT THE YERKES NPRC: AIDS, ANIMAL MODEL

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 描述（由申请人提供）：在过去的八年中，耶基斯国家灵长类动物研究中心（YNPRC）建立、维持和扩大了恒河猴和猪尾猴的SPF群，总共产生了422只SPF猴。 本项目的中心目标是繁殖SPF猕猴（主要是印度血统的恒河猴），这些猕猴是SPF和遗传特征-如国家研究资源中心（NCRR）在RFA RR-02-005中所定义-特别是为美国国立卫生研究院（NIH）支持的艾滋病相关研究的研究人员提供受试者，从而为国家卫生优先事项做出贡献。 这一目标将在YNPRC实现，最初利用现有的422只SPF猕猴（331只印度血统的恒河猴; 91只马尾猴）。 具体来说，现有的印度血统的SPF恒河猴和猪尾群体将通过繁殖增加（2001年，这些SPF组中有100多只幼崽），通过适当的测试和分离，从YNPRC非SPF繁殖群中招募幼崽，并通过增加一小群（N=50）中国起源的恒河猴，以认识到该亚型在一些AIDS研究中的使用越来越多。 该项目的一个创新方面将包括一项研究工作，旨在通过制定一项ART计划来提高资源的价值，以支持SPF计划并提供遗传定义的动物。 该项目的总体目标是提供维持和扩大SPF繁殖群体所需的所有训练有素的人员和资源，并对其进行管理，以优化健康和生殖性能，支持NIH和NCRR确定的国家健康相关优先事项。 YNPRC将与NCRR及其建立的协调委员会密切合作，实施有关统一饲养程序、筛查测试标准化以及委员会可能决定的其他事项的建议。 YNPRC还将与维护NCRR支持的SPF菌落的其他设施以及NCRR确定的任何调查人员协调工作，以最大限度地实现SPF生产的国家优先事项。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): During the past eight years, the Yerkes National Primate Research Center (YNPRC) has established, maintained, and expanded SPF colonies of both rhesus monkeys and pigtailed monkeys producing a total colony of 422 SPF monkeys. The central objective of the present project is to breed SPF macaque monkeys (chiefly rhesus monkeys of Indian ancestry) that are SPF and genetically characterized - as defined by the National Center for Research Resources (NCRR) in RFA RR-02-005 - specifically to provide subjects to the National Institutes of Health (NIH) supported investigators for AIDS related research and thus, to contribute to national health priorities. This objective will be achieved at the YNPRC initially utilizing the existing colony of 422 SPF macaque monkeys (331 rhesus monkeys of Indian ancestry; 91 pigtailed monkeys). Specifically, the existing SPF rhesus of Indian ancestry and pigtailed colonies will be increased via breeding (with over 100 births in these SPF groups in 2001), recruitment of young animals from YNPRC non-SPF breeding colonies via appropriate testing and separation, and by addition of a small (N=50) group of rhesus monkeys of Chinese origin in recognition of the increasing use of this subtype in some AIDS investigations. An innovative aspect of the project will include a research effort designed to enhance the value of the resource by developing a program in ARTs to support the SPF program and to provide for genetically defined animals. The overall aim of the project is to provide all the trained personnel and resources that are necessary to maintain and enlarge SPF breeding groups and to manage them in order to optimize health and reproductive performance in support of national health related priorities established by the NIH and NCRR. The YNPRC will work closely with NCRR and the Coordinating Committee they have established in implementing recommendations regarding uniform husbandry procedures, standardization of screening tests, and such other matters as the committee may decide. The YNPRC also will work in coordination with other facilities maintaining NCRR supported SPF colonies and with any investigators identified by NCRR to maximize the potential that national priorities for SPF production will be attained.