SPF COLONY

SPF菌落

• 批准号: 7562550
• 负责人: THOMAS P GORDON
• 金额: $ 26.18万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562550
• 关键词: Acquired Immunodeficiency Syndrome; Breeding; Computer Retrieval of Information on Scientific Projects Database; Funding; Grant; Health; Health Priorities; Human Resources; Institution; Macaca; Macaca mulatta; Monkeys; National Center for Research Resources; Performance; Procedures; Production; Recommendation; Reproductive Health; Research; Research Personnel; Resources; Screening procedure; Source; Testing; Training; United States National Institutes of Health; Work; germ free condition; juvenile animal

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The central objective of this project is to breed SPF macaque monkeys (chiefly rhesus monkeys of Indian ancestry) that are specific pathogen free (SPF) and genetically characterized - as defined by the National Center for Research Resources in RFA RR-02-005; specifically to provide subjects to NIH supported investigators for AIDS related research and thus to contribute to national health priorities. This objective is achieved at the YNPRC by utilizing an existing colony of SPF macaque monkeys. Specifically, a colony of SPF rhesus of Indian ancestry is grown via breeding, recruitment of young animals from YNPRC non-SPF breeding colonies and via appropriate testing and separation. The overall aim of the project is to provide all the trained personnel and resources that are necessary to maintain and enlarge SPF breeding groups and to manage them in order to optimize health and reproductive performance in support of national health related priorities established by NIH and NCRR. The YNPRC will work closely with NCRR and the Coordinating Committee they have established in implementing recommendations regarding uniform husbandry procedures, standarization of screening tests and such other matters as the committee may decide. The YNPRC works in coordination with other facilities maintaining NCRR supported SPF colonies and with any investigators identified by NCRR to maximize the potential that national priorities for SPF production will be attained.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的中心目标是培育SPF猕猴(主要是印度血统的恒河猴)，这些猕猴是无特定病原体(SPF)和具有基因特征的(由国家研究资源中心在RFA RR-02-005中定义)；具体地说，为NIH支持的研究人员提供艾滋病相关研究的对象，从而为国家卫生优先事项做出贡献。YNPRC通过利用现有的SPF猕猴群体实现了这一目标。具体地说，印度血统的SPF恒河猴群体是通过繁殖、从YNPRC非SPF繁殖群体中招募幼崽以及通过适当的测试和分离来培育的。该项目的总体目标是提供维持和扩大SPF繁育群体所需的所有训练有素的人员和资源，并对其进行管理，以优化健康和生殖性能，以支持NIH和NCRR确定的与国家健康相关的优先事项。YNPRC将与NCRR及其设立的协调委员会密切合作，落实关于统一饲养程序、筛选测试标准化和委员会可能决定的其他事项的建议。YNPRC与维护NCRR支持的SPF菌落的其他设施以及NCRR确定的任何调查人员合作，以最大限度地提高实现SPF生产的国家优先事项的潜力。