SPF BREEDING COLONIES AT THE YERKES NPRC: AIDS, ANIMAL MODEL

YERKES NPRC 的 SPF 繁殖群：艾滋病，动物模型

• 批准号: 7389894
• 负责人: THOMAS P GORDON
• 金额: $ 24.92万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7389894
• 关键词: SPF; BREEDING; COLONIES; YERKES; NPRC

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (Provided by applicant): During the past eight years, the Yerkes National Primate Research Center (YNPRC) has established, maintained, and expanded SPF colonies of both rhesus monkeys and pigtailed monkeys producing a total colony of 422 SPF monkeys. The central objective of the present project is to breed SPF macaque monkeys (chiefly rhesus monkeys of Indian ancestry) that are SPF and genetically characterized - as defined by the National Center for Research Resources (NCRR) in RFA RR-02-005 - specifically to provide subjects to the National Institutes of Health (NIH) supported investigators for AIDS related research and thus, to contribute to national health priorities. This objective will be achieved at the YNPRC initially utilizing the existing colony of 422 SPF macaque monkeys (331 rhesus monkeys of Indian ancestry; 91 pigtailed monkeys). Specifically, the existing SPF rhesus of Indian ancestry and pigtailed colonies will be increased via breeding (with over 100 births in these SPF groups in 2001), recruitment of young animals from YNPRC non-SPF breeding colonies via appropriate testing and separation, and by addition of a small (N=50) group of rhesus monkeys of Chinese origin in recognition of the increasing use of this subtype in some AIDS investigations. An innovative aspect of the project will include a research effort designed to enhance the value of the resource by developing a program in ARTs to support the SPF program and to provide for genetically defined animals. The overall aim of the project is to provide all the trained personnel and resources that are necessary to maintain and enlarge SPF breeding groups and to manage them in order to optimize health and reproductive performance in support of national health related priorities established by the NIH and NCRR. The YNPRC will work closely with NCRR and the Coordinating Committee they have established in implementing recommendations regarding uniform husbandry procedures, standardization of screening tests, and such other matters as the committee may decide. The YNPRC also will work in coordination with other facilities maintaining NCRR supported SPF colonies and with any investigators identified by NCRR to maximize the potential that national priorities for SPF production will be attained.

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。描述（由申请人提供）：在过去的八年中，耶基斯国家灵长类动物研究中心（YNPRC）建立，维护和扩大了恒河猴和尾猴的SPF群体，产生了422只SPF猴子的总群体。本项目的中心目标是培育SPF级猕猴（主要是印度血统的恒河猴），这些猕猴具有SPF级和遗传特征（由国家研究资源中心（NCRR）在RFA RR-02-005中定义），专门为美国国立卫生研究院（NIH）支持的艾滋病相关研究人员提供研究对象，从而为国家卫生优先事项做出贡献。该目标最初将在YNPRC利用现有的422只SPF猕猴（331只印度血统的恒河猴；91只尾猴）实现。具体来说，现有的印度血统的SPF恒河猴和小辫子群体将通过繁殖（2001年这些SPF群体中有超过100只出生），通过适当的测试和分离从YNPRC非SPF繁殖群体中招募幼崽，以及通过增加一小群（N=50）中国血统的恒河猴来增加这一亚型在一些艾滋病调查中的使用。该项目的一个创新方面将包括一项研究工作，旨在通过制定ARTs计划来支持SPF计划并提供基因定义动物，从而提高资源的价值。该项目的总目标是提供维持和扩大SPF繁殖群所需的所有训练有素的人员和资源，并对其进行管理，以便优化健康和生殖性能，以支持国家卫生研究院和国家生殖研究中心确定的与国家卫生有关的优先事项。YNPRC将与NCRR及其建立的协调委员会密切合作，实施关于统一饲养程序、筛选试验标准化以及委员会可能决定的其他事项的建议。国家野生动物保护中心还将与维持国家野生动物保护中心支持的SPF菌落的其他设施以及与国家野生动物保护中心确定的任何调查人员进行协调，以最大限度地发挥国家优先生产SPF的潜力。