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EPSRC NATIONAL MASS SPECTROMETRY SERVICE CENTRE AT SWANSEA 2007 to 2012

EPSRC 斯旺西国家质谱服务中心 2007 年至 2012 年

基本信息

批准号：
EP/F014341/1
负责人：
Anthony Brenton
金额：
$ 371.91万
依托单位：
Swansea University
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2007
资助国家：
英国
起止时间：
2007 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FF014341%2F1
关键词：
EPSRC NATIONAL MASS SPECTROMETRY SERVICE

项目摘要

The continuation of the EPSRC National Mass Spectrometry Service Centre (NMSSC) at Swansea will ensure that a proven high-quality mass spectrometry service at a very reasonable cost will be delivered to the UK Chemistry research base. This vital facility will help underpin the competitiveness of UK Science by providing excellent service quality with rapid sample turnaround time and high analytical success rate. The track record of the Centre at Swansea, extending over twenty years of exemplary service to the chemistry community, is attested with attainment of an unprecedented full set of six top-performance indicators from the Research Council's annual review panel in 2005. Most universities have their own mass spectrometers and the role of the service will shift to reflect this by: i) assisting departmental services to obtain good quality data on their own instruments; ii) assisting chemists to understand the data and use it appropriately and iii) analysing the samples that cannot be done in-house, either because of lack of technology or lack of expertise.Two new instruments are requested to replace three long-service mass spectrometers, both to maintain and to improve the present level of service, whilst increasing the capability for accurate mass measurement and complex sample analysis. Additionally, the limited remaining areas of analytical difficulty will be tackled by the purchase of relatively minor items of equipment, special spectrometer features and targeted research projects. These improvements will assist the National Centre to keep pace with the progress of modern chemistry and its broadening interface with other disciplines.Service activities such as matrix-assisted laser desorption/ionisation and other difficult analyses are expected to increase, and the publicity and training portfolios will increase concomitantly to extend the service into new areas of science and offset the growing usage and complexity of mass spectrometry. The training programme will assist departments to use the National Service and their own equipment more effectively, and thus also add value to previous research council investments. Outreach to the chemistry community will be by collaborations, shared doctoral training account studentships, and consultation on matters of the Centre's expertise, including instrument procurement, if required. The WWW will assist dissemination of knowledge.Scheduling time for use of the service will continue to be by a documented process monitored annually by the external Management Advisory Panel, and biased heavily towards EPSRC-funded research, ensuring that internationally competitive research is supported.The service will continue to provide high quality data, spectral interpretation and educational commentary on the results. Programmes for staying at the forefront of technology and maintaining professional standards of staff will also be in place.Another improvement to the Service will include extension of the Electronic Customer Interface whereby users log their samples for analysis and view the results electronically. The electronic interface will also allow future provision of an archive of mass spectral information of unique samples as a national resource. A key feature of the new Service will be routine accurate mass measurement of molecular and fragment ions with increased use of isotope information, these together will be a powerful tool for the unambiguous characterisation of chemical substances even when present in a mixture.Enhanced performance will be achieved by using key performance indicators to improve the quality of service and level of customer satisfaction.A strength of the Swansea NMSSC is its presence in the mass spectrometry-rich academic and research environment of the Institute of Mass Spectrometry.Resource accruing to the host institution from this grant will be used for further research in mass spectrometry and analytical chemistry.

位于斯旺西的EPSRC国家质谱学服务中心(NMSSC)的继续存在将确保以非常合理的成本向英国化学研究基地提供经过验证的高质量质谱学服务。这一至关重要的设施将通过提供卓越的服务质量、快速的样品周转时间和高分析成功率来帮助巩固英国科学公司的竞争力。设在斯旺西的中心为化学界提供了二十多年的模范服务，其记录得到了证明，2005年研究理事会的年度审查小组获得了史无前例的全套六项最高绩效指标。大多数大学都有自己的质谱仪，而该部门的角色将会转变，以反映这一点：(I)协助部门部门从其仪器上获得高质量的数据；(Ii)协助化学家了解数据并恰当地使用；以及(Iii)分析由于缺乏技术或专业知识而无法在内部完成的样本。需要两台新仪器来取代三台长期使用的质谱仪，以维持和改善现有的服务水平，同时提高准确质量测量和复杂样本分析的能力。此外，有限的剩余分析困难领域将通过购买相对较小的设备、特殊光谱仪功能和有针对性的研究项目来解决。这些改进将帮助国家中心跟上现代化学的进步及其与其他学科不断扩大的接口。预计基质辅助激光解吸/电离和其他困难分析等服务活动将增加，宣传和培训组合将随之增加，以将服务扩展到新的科学领域，并抵消质谱学日益增长的使用和复杂性。培训方案将协助各部门更有效地使用国家服务机构及其自身的设备，从而也为研究理事会以前的投资增加价值。与化学界的接触将通过合作、共享博士培训账户学生资格以及就中心的专长事项进行磋商，包括必要时的仪器采购。WWW将帮助传播知识。使用这项服务的时间安排将继续由外部管理咨询小组每年监测的文件化过程进行，并严重偏向EPSRC资助的研究，以确保支持具有国际竞争力的研究。该服务将继续提供高质量的数据、光谱解释和对结果的教育评论。服务的另一项改善将包括扩展电子客户界面，让用户将样本记录下来，以便以电子方式进行分析和查看结果。电子接口还将使今后能够提供独特样品的质谱学信息档案，作为国家资源。新服务的一个主要特点将是分子和碎片离子的常规准确质量测量，增加对同位素信息的使用，这些共同将成为明确描述化学物质特征的强大工具，即使在混合物中也是如此。通过使用关键性能指标来提高服务质量和客户满意度，将实现更高的性能。斯旺西NMSSC的优势在于它存在于质谱学研究所丰富的学术和研究环境中。从这笔拨款中积累的资源将用于质谱学和分析化学的进一步研究。