Developing novel processing technology for solvent-free crystallisation processes / a feasibility study.

该提案解决了某些结晶过程可以使用无溶剂加工路线进行的可能性。这显然不能应用于分批操作顺序中的纯化阶段，因为在此溶剂是纯化系统的重要部分，并且最终将包含所有不需要的副产物。然而，在纯化后和配制前，制药和农用化学品公司通常将活性分子从其游离碱或酸状态转化为具有所需物理化学特性的分子盐或共晶体。该方法通常涉及将成分再溶解在有机溶剂（或溶剂混合物）中并重结晶以产生所需的双组分固体形式。在本提案中，我们将讨论基于组分共研磨的新“无溶剂”工艺技术的可能性。

This proposal addresses the possibility that certain crystallisation processes may be performed using a solvent-free processing route. This clearly cannot apply to the purification stages in a batch operating sequence since here the solvent is an essential part of the purification system and will ultimately contain all the unwanted by-products. However, post-purification and pre-formulation it is usual form pharma and agrochems companies to transform an active molecule from its free base or acid state into a molecular salt or co-crystal having desirable physico-chemical characteristics. This process typically involves redissolution of ingredients in an organic solvent (or solvent mixture) and recrystallisation to create the required two component solid form. In this proposal we will address the possibility of new 'solvent free' process technology based on co-grinding of components.