Wearable Nanosensor Array for Real-Time Monitoring of Diesel and Gasoline Exhaust

描述（由申请人提供）： 当发动机燃烧燃料时产生的柴油和汽油废气是气体和细颗粒的复杂混合物。最近的研究将呼吸道疾病和癌症与接触汽油和柴油废气联系起来。然而，这些疾病也归因于遗传易感性。建立这些疾病与柴油和/或汽油废气的直接联系需要可靠和可重复的定量暴露措施。拟议的合作研究的总体目标是创建、评估和验证一个自主/独立的可穿戴式传感器阵列，大约4”× 4”，用于实时监测通过吸入内燃机废气中的气体成分而暴露的情况。可以作为类似于γ辐射计数器的徽章佩戴的完全集成的轻质传感器将包括电导和电流传感器阵列，以及用于功率管理、数据收集、信号处理和无线通信的低功率完全集成的微电子器件。独立传感器阵列可提供更多关于个人接触的分析信息，因此在实时选择性和准确监测低浓度的移动的源空气有毒物质和其他相关污染物方面具有巨大潜力。电导和电流平台具有互补的优势，并且非常兼容1C。先进的数据处理将用于产生不同的响应模式和检测气体混合物中的单个化合物。两个强大的检测方案的这种明智的集成沿着智能数据处理应当显著地增加关于个人暴露的所收集的信息，以提供显著的可靠性沿着广泛的范围，同时满足分散检测系统的便携性要求。我们的多学科专业知识、广泛的初步数据和过去成功的合作为拟议的活动奠定了基础。总体目标将通过以下方式实现：1）开发、优化、表征和测试电导纳米传感器阵列，2）开发、优化、表征和测试微制造电流传感器阵列，3）开发用于最佳功率管理、数据收集和信号处理以及远程通信的集成微电子器件，4）将电导传感器阵列和电流传感器阵列集成在具有结合的微电子器件的单个平台中，以及5）通过真实的监测来测试和验证可穿戴传感器阵列。时间柴油和汽油废气在现实的暴露条件下。

DESCRIPTION (provided by applicant): Diesel and gasoline exhaust, produced when an engine burns fuel, is a complex mixture of gases and fine particles. Recent studies have linked respiratory diseases and cancer to exposure to gasoline and diesel exhaust. These diseases, however, are also attributed to genetic susceptibility. Establishing a direct linkage of these diseases to diesel and/or gasoline exhaust requires reliable and reproducible quantitative measure of exposure. The overall aim of the proposed collaborative research is to create, evaluate and validate an autonomous/self-contained wearable, approximately 4" by 4", sensor array for the real-time monitoring of exposure through inhalation to the gaseous components of internal combustion engine exhaust. The fully integrated light weight sensor that can be worn as badge similar to y-radiation counter will comprise an array of conductometric and amperometric sensors, and low-power fully integrated microelectronics for power management, data collection, and signal processing and wireless communications. Arrays of independent sensors can offer much more analytical information on personal exposure and thus hold a great potential for selective and accurate monitoring of low concentrations of mobile source air toxics and other relevant pollutants in real-time. The conductometric and amperometric platforms have strengths that are complementary to each other and are extremely 1C compatible. Advanced data processing will be used for generating distinct response patterns and detecting the individual compounds in gaseous mixtures. Such judicious integration of two powerful detection schemes along with an intelligent data processing should dramatically increase the gathered information on personal exposure to offer remarkable reliability along with broad scope, while meeting the portability requirements of decentralized detection systems. Our multidisciplinary expertise, extensive preliminary data and successful past collaboration lay the groundwork for the proposed activity. The overall goal will be realized by 1) developing, optimizing, characterizing and testing conductometric nanosensor array, 2) developing, optimizing, characterizing and testing microfabricated amperometric sensor array 3) developing integrated microelectronics for optimal power management, data collection and signal processing and remote communication, 4) integrating conductometric and amperometric sensor arrays in a single platform with incorporated microelectronics and 5) testing and validating the wearable sensor array by monitoring in real-time diesel and gasoline exhausts under realistic exposure conditions.