Wearable Nanosensor Array for Real-Time Monitoring of Diesel and Gasoline Exhaust

描述(由申请人提供)： 柴油和汽油废气是发动机燃烧燃料时产生的，是气体和细颗粒的复杂混合物。最近的研究将呼吸道疾病和癌症与接触汽油和柴油废气联系在一起。然而，这些疾病也被归因于遗传易感性。要确定这些疾病与柴油和/或汽油废气之间的直接联系，就需要可靠和可重复的接触量化措施。拟议合作研究的总体目标是创建、评估和验证自主/自给式可穿戴传感器阵列，用于实时监测通过吸入内燃机废气成分而暴露的情况。可以作为徽章佩戴的全集成轻量传感器类似于辐射计数器，将包括一组电导和安培传感器，以及用于电源管理、数据采集、信号处理和无线通信的低功率全集成微电子设备。独立传感器阵列可以提供更多关于个人接触的分析信息，因此在选择性和准确地实时监测低浓度移动源空气有毒物质和其他相关污染物方面具有很大潜力。电导测量平台和安培测量平台的优势是相辅相成的，并且非常兼容1C。先进的数据处理将用于产生不同的响应模式和检测气体混合物中的单独化合物。这种明智地将两个强大的检测方案与智能数据处理结合在一起，应该会极大地增加收集的个人暴露信息，以提供显著的可靠性和广泛的范围，同时满足分散检测系统的便携性要求。我们的多学科专业知识、广泛的初步数据和过去的成功合作为拟议的活动奠定了基础。总体目标将通过1)开发、优化、表征和测试电导纳米传感器阵列，2)开发、优化、表征和测试微制造安培传感器阵列3)开发用于优化电源管理、数据采集、信号处理和远程通信的集成微电子技术，4)将电导和安培传感器阵列集成在一个集成了微电子技术的平台中，以及5)通过在真实暴露条件下实时监测柴油和汽油排放来测试和验证可穿戴传感器阵列。

DESCRIPTION (provided by applicant): Diesel and gasoline exhaust, produced when an engine burns fuel, is a complex mixture of gases and fine particles. Recent studies have linked respiratory diseases and cancer to exposure to gasoline and diesel exhaust. These diseases, however, are also attributed to genetic susceptibility. Establishing a direct linkage of these diseases to diesel and/or gasoline exhaust requires reliable and reproducible quantitative measure of exposure. The overall aim of the proposed collaborative research is to create, evaluate and validate an autonomous/self-contained wearable, approximately 4" by 4", sensor array for the real-time monitoring of exposure through inhalation to the gaseous components of internal combustion engine exhaust. The fully integrated light weight sensor that can be worn as badge similar to y-radiation counter will comprise an array of conductometric and amperometric sensors, and low-power fully integrated microelectronics for power management, data collection, and signal processing and wireless communications. Arrays of independent sensors can offer much more analytical information on personal exposure and thus hold a great potential for selective and accurate monitoring of low concentrations of mobile source air toxics and other relevant pollutants in real-time. The conductometric and amperometric platforms have strengths that are complementary to each other and are extremely 1C compatible. Advanced data processing will be used for generating distinct response patterns and detecting the individual compounds in gaseous mixtures. Such judicious integration of two powerful detection schemes along with an intelligent data processing should dramatically increase the gathered information on personal exposure to offer remarkable reliability along with broad scope, while meeting the portability requirements of decentralized detection systems. Our multidisciplinary expertise, extensive preliminary data and successful past collaboration lay the groundwork for the proposed activity. The overall goal will be realized by 1) developing, optimizing, characterizing and testing conductometric nanosensor array, 2) developing, optimizing, characterizing and testing microfabricated amperometric sensor array 3) developing integrated microelectronics for optimal power management, data collection and signal processing and remote communication, 4) integrating conductometric and amperometric sensor arrays in a single platform with incorporated microelectronics and 5) testing and validating the wearable sensor array by monitoring in real-time diesel and gasoline exhausts under realistic exposure conditions.