Core--Morphometry and Physiology

核心——形态测量与生理学

• 批准号: 7491185
• 负责人: William C Sessa
• 金额: $ 15.87万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7491185
• 关键词: Arteriosclerosis; Evaluation; In Vitro; Physiological; Physiology; Purpose; Vasomotor; in vivo; morphometry

The purposes of the Morphometry and Physiology Core are to evaluate the morphometric and physiological changes that occur during graft arteriosclerosis (GA) that culminate in constrictive remodeling and to assess the vasomotor function during the progression of GA in vitro. The combination of histological assessment and morphometric evaluation in conjunction with vessel physiology will allow us to dissect when vasomotor function contributes to GA remodeling. This Core will interface with Projects by Pober, Min, and Tellides to assess the degree of remodeling and function in vessels undergoing GA in vivo.

形态学和生理学核心的目的是评价移植物动脉硬化（GA）过程中发生的形态学和生理学变化，最终导致收缩性重塑，并评估体外GA进展过程中的血管功能。结合组织学评估和形态学评估以及血管生理学，我们可以在血管功能有助于GA时进行解剖 重塑该核心将与Pober、Min和Tellides的项目对接，以评估体内接受GA的血管的重塑和功能程度。