Monolithic integration of optical traps and microfluidic channels

光阱和微流体通道的单片集成

• 批准号: EP/F020589/1
• 负责人: Thomas Krauss
• 金额: $ 86.42万
• 依托单位: University of St Andrews
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF020589%2F1
• 关键词: Monolithic; integration; optical; traps; microfluidic

The key motivation for the project is to make the optical trapping toolkit more accessible to the life sciences community. By integrating optical traps directly into microfluidic circuitry, we will add functionality to Lab-on-a-chip type devices, thus taking them a step closer to real applications. We will reach this aim by developing the concept of an integrated optical trap that we have demonstrated recently. The trap will be made more versatile by increasing its power output and by using beamshaping to increase the intensity in the optical trap, thus being able to control a large number of different cell types. An optical chromatography device that offers the fast and simple fractionation of a cell population will be developed, with integrated separation channels that are optically addressed. Realising circuits at other wavelengths, namely 780 nm for Raman spectroscopy and 635 as well as 410 nm for fluorescence excitation, will highlight the potential of the integrated trap concept further.

该项目的主要动机是使生命科学界更容易获得光学捕获工具包。通过将光阱直接集成到微流体电路中，我们将为芯片实验室类型的设备添加功能，从而使它们更接近真实的应用。我们将通过发展我们最近展示的集成光阱的概念来实现这一目标。通过增加其功率输出和使用光束整形来增加光阱中的强度，将使阱变得更加通用，从而能够控制大量不同的细胞类型。将开发一种光学色谱装置，该装置提供细胞群体的快速和简单的分级分离，具有光学寻址的集成分离通道。在其他波长实现电路，即用于拉曼光谱的780 nm和用于荧光激发的635 nm以及410 nm，将进一步突出集成阱概念的潜力。

项目成果

Design of a high-performance optical tweezer for nanoparticle trapping

• DOI: 10.1007/s00339-016-9894-0
• 发表时间: 2016-03
• 期刊: Applied Physics A
• 作者: D. Conteduca;F. Dell’Olio;C. Ciminelli;T. Krauss;M. Armenise

Ultra-high Q/V hybrid cavity for strong light-matter interaction

• DOI: 10.1063/1.4994056
• 发表时间: 2017-08-01
• 期刊: APL PHOTONICS
• 影响因子: 5.6
• 作者: Conteduca, Donato;Reardon, Christopher;Ciminelli, Caterina
• 通讯作者: Ciminelli, Caterina

Slotted Photonic Crystal Waveguides and Cavities

开槽光子晶体波导和腔

• DOI: 10.1364/ipnra.2008.imd2
• 发表时间: 2008
• 作者: Di Falco A