NATIONAL SWINE RESEARCH AND RESOURCE CENTER

国家猪研究和资源中心

• 批准号: 7621966
• 负责人: LELA K. RILEY
• 金额: $ 56.89万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7621966
• 关键词: Address; Biomedical Research; Communities; Computer Retrieval of Information on Scientific Projects Database; Country; Cryopreservation; Detection; Development; Discipline; Disease; Educational Activities; Embryo; Engineering; Ensure; Family suidae; Funding; Future; Germ Cells; Goals; Grant; Health; Human; Institution; Knock-out; Maintenance; Methods; Modeling; Monitor; Prevention; Production; Reagent; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Scientist; Site; Somatic Cell; Source; Sus scrofa; Tissues; Training; Transgenic Organisms; United States National Institutes of Health; animal resource; base; experience; human disease; improved; innovation; microbial; pathogen; prevent; skills

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Significant progress is being made toward prevention and cures for many human diseases via swine-based research. Unfortunately, there are several major impediments to the realization of the full potential of pigs as models of human disease. The overall goal for this application is to establish a National Swine Research and Resource Center (NSRRC), which will address these major impediments. The proposed NSRRC will develop the infrastructure to ensure that biomedical investigators across a variety of disciplines have access to critically needed swine models of human health and disease. The NSRRC will also serve as a central resource for reagents, information and training related to swine models. An interdisciplinary team of scientists exists at the MU with experience in establishing and operating successful animal resource centers and each of the disciplines required to operate the NSRRC. No other place in the country possesses this array of skills and resources. The Specific Aims are: 1. To develop a National Swine Research and Resource Center. Functions of the NSRRC will include: (a) Importation of existing swine models of human health and disease, (b) rederivation of pigs to eliminate pathogens and health monitoring to assure maintenance of a pathogen-free status, (c) cryopreservation and storage of gametes, embryos and somatic cells to prevent future loss of valuable models, (d) distribution of high quality, pathogen-free pigs, and (e) creation of genetically-engineered pigs. 2. To perform innovative research that will benefit the NSRRC and the biomedical research community. Research projects are aimed at improving: a) the cryopreservation of pig reproductive cells and tissues; and b) the detection and elimination of microbial pathogens in pigs, reproductive cells and tissues; and c) development of improved methods for the production of transgenic and knockout pigs. The NSRRC will also serve as a site for training and educational activities related to research employing swine models.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 描述（由申请人提供）： 通过以猪为基础的研究，在预防和治疗许多人类疾病方面正在取得重大进展。不幸的是，在实现猪作为人类疾病模型的全部潜力方面存在几个主要障碍。这项申请的总体目标是建立一个国家猪研究和资源中心（NSRRC），以解决这些主要障碍。拟议的NSRRC将开发基础设施，以确保跨学科的生物医学研究人员能够获得急需的人类健康和疾病的猪模型。NSRRC还将作为与猪模型相关的试剂、信息和培训的中心资源。MU有一个跨学科的科学家团队，他们在建立和运营成功的动物资源中心以及运营NSRRC所需的每个学科方面都有经验。全国没有其他地方拥有这样的技能和资源。 具体目标是： 1.建立国家养猪研究和资源中心。国家社会救济和资源委员会的职能包括：（a）引进现有的人类健康和疾病的猪模型，（B）对猪进行再衍生以消除病原体，并进行健康监测以确保保持无病原体状态，（c）冷冻保存和储存配子、胚胎和体细胞以防止将来丢失有价值的模型，（d）分发高质量的无病原体猪，以及（e）创造基因工程猪。 2.进行创新研究，这将有利于NSRRC和生物医学研究界。 研究项目旨在改进：（a）猪生殖细胞和组织的冷冻保存;（B）检测和消除猪、生殖细胞和组织中的微生物病原体;（c）开发生产转基因和基因敲除猪的改进方法。NSRRC还将作为与使用猪模型的研究相关的培训和教育活动的场所。