The Development of Metal Catalysed Benzannulation Protocols for the Synthesis of Aromatic Boronic Esters

有机化学家构建分子的一个关键过程是通过碳-碳键形成反应。该工艺的前驱体应稳定，易于使用，并在温和的条件下有效地形成关键的C-C键。芳香硼酸和硼酸酯就是这样一类有机化合物。事实上，它们的稳定性和多用途反应性使它们成为现代有机合成中最有价值的合成中间体之一。我们已经找到了一种非常快速地获得这些化合物的不同寻常的方法，但我们目前的方法通常需要高温和长时间的反应。我们希望通过引入环加成策略的金属催化变体来加速这些过程，并允许它们在较低的温度下运行。这些过程将产生同样重要的合成中间体，但要在使这些反应更经济、更有吸引力的条件下进行。

A key process by which organic chemists build molecules is via carbon-carbon bond forming reactions. The precursors of this process should be stable, easy to use and undergo the key C-C bond formation efficiently under mild conditions. Aromatic boronic acids and esters are one such class of organic compounds. Indeed, their stability and versatile reactivity make them one of the most valuable classes of synthetic intermediates in modern organic synthesis. We have found an unusual way to access these compounds very quickly, but our current approaches often require high temperatures and long reaction times. We hope to speed up these processes and allow them to run at lower temperatures by introducing metal catalysed variants of the cycloaddition strategy. These processes will deliver equally important synthetic intermediates, but under conditions that make these reactions more economical and more attractive.