The Development of Metal Catalysed Benzannulation Protocols for the Synthesis of Aromatic Boronic Esters

金属催化苯并环化反应合成芳香硼酯的研究进展

• 批准号: EP/F024118/1
• 负责人: Joseph Harrity
• 金额: $ 14.06万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF024118%2F1
• 关键词: Development; Metal; Catalysed; Benzannulation; Protocols

A key process by which organic chemists build molecules is via carbon-carbon bond forming reactions. The precursors of this process should be stable, easy to use and undergo the key C-C bond formation efficiently under mild conditions. Aromatic boronic acids and esters are one such class of organic compounds. Indeed, their stability and versatile reactivity make them one of the most valuable classes of synthetic intermediates in modern organic synthesis. We have found an unusual way to access these compounds very quickly, but our current approaches often require high temperatures and long reaction times. We hope to speed up these processes and allow them to run at lower temperatures by introducing metal catalysed variants of the cycloaddition strategy. These processes will deliver equally important synthetic intermediates, but under conditions that make these reactions more economical and more attractive.

有机化学家构建分子的一个关键过程是通过碳-碳键形成反应。该方法的前体应该是稳定的，易于使用的，并且在温和的条件下有效地进行关键的C-C键形成。芳香族硼酸和酯就是这样一类有机化合物。事实上，它们的稳定性和多功能反应性使它们成为现代有机合成中最有价值的合成中间体之一。我们已经找到了一种非常快速地获得这些化合物的不寻常的方法，但我们目前的方法通常需要高温和长反应时间。我们希望通过引入环加成策略的金属催化变体来加快这些过程并使它们在较低温度下运行。这些过程将提供同样重要的合成中间体，但条件使这些反应更经济，更有吸引力。

项目成果

Stereoselective approaches to 2,3,6-trisubstituted piperidines. An enantiospecific synthesis of quinolizidine (-)-217A.

2,3,6-三取代哌啶的立体选择性方法。

• DOI: 10.1039/c1cc13048j
• 发表时间: 2011
• 期刊: Chemical communications (Cambridge, England)
• 作者: Mancey NC