A CYCLOADDITION STRATEGY FOR ARYLPHOSPHINE SYNTHESIS

芳基膦合成的环加成策略

• 批准号: EP/D03213X/1
• 负责人: Joseph Harrity
• 金额: $ 12.75万
• 依托单位: University of Sheffield
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2006
• 资助国家: 英国
• 起止时间: 2006 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FD03213X%2F1
• 关键词: CYCLOADDITION; STRATEGY; ARYLPHOSPHINE; SYNTHESIS

Small quantites of metal catalysts can greatly affect the chemistry of simple organic molecules, leading to more efficient and cost effective processes. The metallic agent is very often added to a reaction as a complex, meaning that the metal centre is surrounded by other organic molecules known as ligands. The ligands help solubilise the metal species but they also play an important role in fine tuning the chemistry that takes place at the metal centre. This project aims to develop a very quick method for making a wide range of ligands that are based around a phosphorus centre. Indeed, phosphine based ligands are amongst the most popular and important in metal catalysed reactions. If successful, this project will deliver new ligands that have the potential to greatly improve the efficiency and selectivity of many reactions, allowing a diverse range of fine chemicals to be made available by cheap and simple processes.

少量的金属催化剂可以极大地影响简单有机分子的化学反应，从而实现更高效、更经济的工艺。金属助剂通常作为络合物加入到反应中，这意味着金属中心被称为配体的其他有机分子所包围。配体有助于溶解金属，但它们在微调金属中心发生的化学反应中也起着重要作用。该项目旨在开发一种非常快速的方法来制造基于磷中心的各种配体。事实上，膦基配体是金属催化反应中最受欢迎和最重要的配体之一。如果成功，该项目将提供新的配体，有可能大大提高许多反应的效率和选择性，使各种各样的精细化学品能够通过廉价和简单的过程获得。

项目成果

Synthesis, characterisation and reactions of phosphine-substituted alkynylboronates and alkynyltrifluoroborate salts.

• DOI: 10.3390/molecules191221324
• 发表时间: 2014-12-18
• 期刊: Molecules (Basel, Switzerland)
• 作者: Vivat JF;Bachollet SP;Adams H;Harrity JP
• 通讯作者: Harrity JP

Development of a mild and versatile directed cycloaddition approach to pyridines.

• DOI: 10.1002/chem.201403916
• 发表时间: 2014-09-26
• 期刊: CHEMISTRY-A EUROPEAN JOURNAL
• 影响因子: 4.3
• 作者: Bachollet, Sylvestre P. J. T.;Vivat, Jerome F.;Cocker, Dean C.;Adams, Harry;Harrity, Joseph P. A.
• 通讯作者: Harrity, Joseph P. A.