Feasibility Study: A Novel Technique for Forming Diffusion-Controlled Drug Delivery Polymer Microcapsules

可行性研究：一种形成扩散控制药物输送聚合物微胶囊的新技术

• 批准号: EP/F031122/1
• 负责人: Eleanor Stride
• 金额: $ 10.49万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF031122%2F1
• 关键词: Feasibility; Study; Novel; Technique; Forming

The development of microdevices for controlled drug delivery is currently an area of intense research activity. These devices enable localized administration of a given agent in vivo which maximises patient safety and comfort and can greatly reduce treatment costs. There are, however, two significant barriers in terms of cost and reliability which have hindered their uptake in clinical practice. Firstly, methods for efficient drug encapsulation which are both cost-effective and provide adequate quality control are lacking. In this proposal we identify a novel approach to drug encapsulation based on co-axial electro-hydrodynamic flow which offers a simple, one-step method for the mass production of polymer microcapsules. Secondly, a reliable means of controlling and/or varying the rate of drug release has yet to be developed. We will investigate the use of ultrasound to vary the rate of diffusion from implanted/injected devices to provide a means of controlling drug administration that is accurate and non-invasive. A successful outcome will have significant impact for the pharmaceutical and healthcare industries, from whom the project has already attracted considerable support, and will provide the basis for future, larger research projects to develop the work.

用于受控药物递送的微型装置的开发是当前激烈的研究活动的领域。这些装置能够在体内局部施用给定的药剂，这最大化了患者的安全性和舒适性，并且可以大大降低治疗成本。然而，在成本和可靠性方面存在两个重大障碍，阻碍了它们在临床实践中的应用。首先，缺乏既有成本效益又能提供足够质量控制的有效药物包封方法。在这个建议中，我们确定了一种新的方法，药物封装同轴电流体动力学流动的基础上，提供了一个简单的，一步的方法，大规模生产的聚合物微胶囊。第二，控制和/或改变药物释放速率的可靠手段还有待开发。我们将研究使用超声波改变植入/注射器械的扩散速率，以提供一种准确且非侵入性的药物给药控制方法。一个成功的结果将对制药和医疗保健行业产生重大影响，该项目已经吸引了相当大的支持，并将为未来更大的研究项目提供基础。

项目成果

Dynamics of bubble formation in highly viscous liquids.

• DOI: 10.1021/la703849x
• 发表时间: 2008-03
• 期刊: Langmuir : the ACS journal of surfaces and colloids
• 作者: K. Pancholi;E. Stride;M. Edirisinghe

In vitro method to characterize diffusion of dye from polymeric particles: a model for drug release.

表征染料从聚合物颗粒扩散的体外方法：药物释放模型。

• DOI: 10.1021/la900694k
• 发表时间: 2009
• 期刊: the ACS journal of surfaces and colloids
• 作者: Pancholi K