Engineering Microbubbles for Enhanced Non-linear Response: Modelling and Experimental Studies

用于增强非线性响应的工程微泡：建模和实验研究

• 批准号: EP/G031754/1
• 负责人: Eleanor Stride
• 金额: $ 51.86万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG031754%2F1
• 关键词: Engineering; Microbubbles; Enhanced; Non; linear

The non-linear response of gas bubbles to acoustic excitation is an important phenomenon in both the biomedical and engineering sciences. In medical ultrasound imaging, for example, microbubbles are particularly useful as contrast agents on account of their ability to scatter ultrasound non-linearly. Increasing the degree of non-linearity, however, normally requires an increase in the amplitude of excitation and this may also result in violent behaviour such as inertial cavitation and bubble fragmentation; effects which may be highly undesirable, especially in biomedical applications. The aim of the work described in this proposal is to investigate the findings from our recent preliminary study which showed that by depositing nanoparticles on the surface of a microbubble, the non-linear character of its acoustic response can be increased significantly at low excitation amplitudes. We propose to develop a theoretical model to predict this behaviour and to examine the effect upon bubble stability; and to carry out systematic experimental investigations of the influence of nanoparticle size, shape and concentration upon the stability and acoustic response of microbubbles in order to verify the theoretical work. A successful outcome will lead to the development of microbubble agents with improved efficacy and predictability, for both imaging and therapeutic applications, that will offer significant benefits to the pharmaceutical and healthcare industries, instrumentation manufacturers and ultimately clinicians and patients.

气泡对声激励的非线性响应是生物医学和工程科学中的一个重要现象。例如，在医学超声成像中，微泡作为造影剂特别有用，因为它们能够非线性地散射超声。然而，增加非线性程度通常需要增加激励幅度，这也可能导致惯性空化和气泡破碎等剧烈行为；可能非常不希望有的影响，特别是在生物医学应用中。本提案中描述的工作的目的是调查我们最近的初步研究结果，该研究结果表明，通过在微泡表面沉积纳米颗粒，可以在低激励振幅下显着增加其声学响应的非线性特征。我们建议开发一个理论模型来预测这种行为并检查其对气泡稳定性的影响；开展系统的实验研究纳米颗粒尺寸、形状和浓度对微泡稳定性和声响应的影响，以验证理论工作。成功的结果将导致开发出具有更高功效和可预测性的微泡剂，用于成像和治疗应用，这将为制药和医疗保健行业、仪器制造商以及最终的临床医生和患者带来显着的好处。

项目成果

The effect of surfactant type and concentration on the size and stability of microbubbles produced in a capillary embedded T-junction device

• DOI: 10.1039/c4ra15167d
• 发表时间: 2015-01-01
• 期刊: RSC ADVANCES
• 影响因子: 3.9
• 作者: Parhizkar, M.;Edirisinghe, M.;Stride, E.
• 通讯作者: Stride, E.

Nanoparticle delivery systems formed using electrically sprayed co-flowing excipients and active agent.

• DOI: 10.1166/jbn.2011.1353
• 发表时间: 2011-12
• 期刊: Journal of biomedical nanotechnology
• 影响因子: 2.9
• 作者: R. Bakhshi;Z. Ahmad;M. Soric;E. Stride;M. Edirisinghe

A novel hybrid system for the fabrication of a fibrous mesh with micro-inclusions.

一种用于制造具有微夹杂物的纤维网的新型混合系统。

• DOI: 10.1016/j.carbpol.2012.02.074
• 发表时间: 2012
• 期刊: Carbohydrate polymers
• 影响因子: 11.2
• 作者: Ahmad B