Feasibility study of novel hand hygiene formulations against bacterial spore infection
新型手部卫生制剂对抗细菌芽孢感染的可行性研究
基本信息
- 批准号:10542696
- 负责人:
- 金额:$ 26.66万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-09-19 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlcoholsAnimalsBacillusBacillus cereusBacillus subtilisBacteriaBacterial SporesBeveragesCellsCenters for Disease Control and Prevention (U.S.)Clostridium difficileCollaborationsConsultDataDevelopmentDiagnosisDisinfectantsDrainage procedureEffectivenessEnvironmentEpigallocatechin GallateFeasibility StudiesFoodFood IndustryFood PoisoningFormulationFundingFutureGelGeneral PopulationGermicideGerminationGoalsGrantHandHand functionsHealthHealthcareHomeHumanHygieneIndustrial fungicideIndustryInfectionInfection preventionLaboratoriesLaboratory ResearchLegal patentLiquid substanceLocal Anti-Infective AgentsLong-Term CareMethodsMonographOperative Surgical ProceduresPalmitatesPathogenicityPersonsPhasePrevention strategyProcessPublishingRegulationReproduction sporesResearch PersonnelResistanceRiskSkinSmall Business Technology Transfer ResearchSoapsSurfaceSuspensionsSystemTechnologyTestingToxic effectUnited StatesUnited States National Institutes of HealthUniversitiesWaterWorkbactericidebasecare systemsclinical riskcommercializationcytotoxicitycytotoxicity testefficacy testingexperienceexperimental studyfeasibility testinghealth care settingshealthcare-associated infectionshigh riskhigh risk populationhuman old age (65+)novelopportunistic pathogenpathogenic bacteriapreventproduct developmentprototyperesearch and developmentsafety testingstability testingvirucide
项目摘要
Project Summary:
Spore-forming bacterial species, such as various Bacilli and Clostridia, undergo a sporulation
process under unfavorable conditions to form dormant spores. These bacterial spores have
become a threat to the food industry as they can cause food spoilage and food poisoning. In
addition, an opportunistic pathogen, Clostridium difficile (C. difficile), one of the five CDC-
listed urgent threats, causes Clostridium difficile infection (CDI) in the healthcare and long-
term care systems. Unfortunately, there are currently no sporicidal hand hygiene products.
Hand wash with soap and water is the only recommended method to prevent CDI either in
healthcare settings or at home (CDC, C. difficile: Prevent the spread of C. difficile). It is known
that soap and water do not inactivate bacterial spores, but rather remove them from the skin
into the water drainage system. Thus, hand hygiene methods with high sporicidal activity, yet
without toxicity, are in urgent need to better protect the general population from infections
caused by spore-forming bacteria. Based on patented and patent-pending technologies,
Camellix, LLC has developed novel alcohol-based formulations containing epigallocatechin-3-
gallate-palmitate (EC16), a compound derived from green tea polyphenols, which showed potent
sporicidal activity in initial tests. In the current proposal, investigators from Camellix and Seton
Hall University will: determine and validate the sporicidal activity of novel alcohol-based
formulations containing epigallocatechin-3-gallate-palmitate (EC16) against a wide spectrum of
bacterial spores and can provide novel hand hygiene methods without toxicity (Aim 1). The
selected formulations with potent sporicidal activities will be undergoing test the cytotoxicity,
stability, and efficacy of finalized F1 and F2 identified in Aim 1 in comparison to currently used
methods and products (Aim 2). Supported by an NIH STTR Phase II grant, Camellix is currently
developing novel hand/surface disinfectants according to EPA, FDA and EU regulations and
standards, and achieving expected results, which demonstrates our expertise and experience in
hand hygiene product development. The proposed work will lead to first-in-class nontoxic hand
hygiene prototypes against pathogenic spore-forming bacteria.
项目概要:
孢子形成细菌物种,如各种杆菌和梭菌,经历孢子形成
在不利的条件下形成休眠孢子。这些细菌孢子
成为食品工业的威胁,因为它们可能导致食物腐败和食物中毒。在
此外,机会致病菌,艰难梭菌(C.五个CDC之一,
列出的紧急威胁,导致艰难梭菌感染(CDI)在医疗保健和长期-
长期护理系统。不幸的是,目前没有杀孢子的手部卫生产品。
用肥皂和水洗手是防止CDI的唯一推荐方法,
医疗机构或在家中(CDC,C. difficile:防止C. difficile)。已知
肥皂和水并不能消灭细菌孢子,而是把它们从皮肤上清除掉。
进入排水系统因此,具有高杀孢子活性的手卫生方法,
无毒性,急需更好地保护普通人群免受感染
由孢子形成细菌引起的基于专利和正在申请专利的技术,
Camellix,LLC开发了含有表没食子儿茶素-3-基的新型醇基制剂。
没食子酸棕榈酸酯(EC 16),一种来自绿色茶多酚的化合物,其显示出有效的
在初始测试中的杀孢子活性。在目前的提案中,来自Camellix和Seton的调查人员
霍尔大学将:确定和验证新型醇基杀孢子活性
含有表没食子儿茶素-3-没食子酸酯-棕榈酸酯(EC 16)的制剂对抗广谱的
细菌孢子,并可以提供新的手卫生方法无毒(目标1)。的
将对所选择的具有有效杀孢子活性的制剂进行细胞毒性测试,
目标1中确定的最终F1和F2与当前使用的F1和F2相比的稳定性和疗效
方法和产品(目标2)。在NIH STTR第二阶段资助的支持下,Camellix目前正在
根据EPA、FDA和欧盟法规开发新型手/表面消毒剂,
标准,并达到预期的结果,这表明我们的专业知识和经验,
手卫生产品开发。这项拟议的工作将导致一流的无毒手
针对致病孢子形成细菌的卫生原型。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Stephen Hsu其他文献
Stephen Hsu的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Stephen Hsu', 18)}}的其他基金
Novel Nasal Formulations Containing EC16 for Minimizing COVID-19-Associated Anosmia
含有 EC16 的新型鼻用制剂可最大限度地减少与 COVID-19 相关的嗅觉丧失
- 批准号:
10543912 - 财政年份:2022
- 资助金额:
$ 26.66万 - 项目类别:
相似海外基金
Collaborative Research: Overlooked Oxidation of Aqueous Alcohols: Kinetics, Mechanism, and Relevance to Water Reuse
合作研究:被忽视的水醇氧化:动力学、机制以及与水回用的相关性
- 批准号:
2304861 - 财政年份:2023
- 资助金额:
$ 26.66万 - 项目类别:
Continuing Grant
STTR Phase I: Development of Modular Reactors to Convert Methane to Alcohols at Low Temperatures
STTR 第一阶段:开发在低温下将甲烷转化为醇的模块化反应器
- 批准号:
2151256 - 财政年份:2023
- 资助金额:
$ 26.66万 - 项目类别:
Standard Grant
Development of amine-dehydrogenase and lyase biocatalysts for the sustainable manufacturing of unnatural chiral amino acids and amino alcohols
开发胺脱氢酶和裂解酶生物催化剂,用于可持续生产非天然手性氨基酸和氨基醇
- 批准号:
2870226 - 财政年份:2023
- 资助金额:
$ 26.66万 - 项目类别:
Studentship
Collaborative Research: Overlooked Oxidation of Aqueous Alcohols: Kinetics, Mechanism, and Relevance to Water Reuse
合作研究:被忽视的水醇氧化:动力学、机制以及与水回用的相关性
- 批准号:
2304860 - 财政年份:2023
- 资助金额:
$ 26.66万 - 项目类别:
Continuing Grant
Postdoctoral Fellowship: MPS-Ascend: Development of Selective Reaction Schemes for Photoactivation of Alcohols
博士后奖学金:MPS-Ascend:醇光活化选择性反应方案的开发
- 批准号:
2316541 - 财政年份:2023
- 资助金额:
$ 26.66万 - 项目类别:
Fellowship Award
Development of phosphorylation of alcohols in protein based on the structural modification of phosphoenolpyruvate
基于磷酸烯醇丙酮酸结构修饰的蛋白质醇磷酸化研究进展
- 批准号:
22KJ1152 - 财政年份:2023
- 资助金额:
$ 26.66万 - 项目类别:
Grant-in-Aid for JSPS Fellows
Nickel Cross-Coupling Cascades with α-Heteroatom Radicals to Prepare Sterically Hindered Alcohols and Amines
镍与α-杂原子自由基交叉偶联级联制备位阻醇和胺
- 批准号:
10604535 - 财政年份:2023
- 资助金额:
$ 26.66万 - 项目类别:
Towards a better understanding of the effect of the pentafluorosulfanyl group on the lipophilicity and acid/base properties of alcohols and amines
更好地了解五氟硫基对醇和胺的亲脂性和酸/碱性质的影响
- 批准号:
571856-2021 - 财政年份:2022
- 资助金额:
$ 26.66万 - 项目类别:
Alliance Grants
Pd-Catalyzed C(sp3)-H Functionalizations Directed by Free Alcohols and Boc-Protected Amines
由游离醇和 Boc 保护的胺引导的 Pd 催化 C(sp3)-H 官能化
- 批准号:
10606508 - 财政年份:2022
- 资助金额:
$ 26.66万 - 项目类别:
Facile One-Pot Reductive Deoxygenations of Alcohols and Carboxylic Acids Using Sulfuryl Fluoride
使用硫酰氟轻松进行醇和羧酸的一锅还原脱氧
- 批准号:
546996-2020 - 财政年份:2022
- 资助金额:
$ 26.66万 - 项目类别:
Alexander Graham Bell Canada Graduate Scholarships - Doctoral