The Effect of Age on Neuromorphology and its Cognitive Consequences

年龄对神经形态的影响及其认知后果

• 批准号: 7420935
• 负责人: ADAM M BRICKMAN
• 金额: $ 15.6万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7420935
• 关键词: Accounting; Address; African American; Age; Aging; Alzheimer' s Disease; Anterior; Attenuated; Blood Vessels; Brain; Brain region; Caucasians; Caucasoid Race; Clinical; Cognition; Cognitive; Cognitive aging; Cohort Studies; Communities; Data; Dementia; Development; Diabetes Mellitus; Diffuse; Elderly; Epidemiologic Methods; Epidemiologic Studies; Ethnic Origin; Ethnic group; Etiology; Funding; Goals; Gray unit of radiation dose; Height; Hispanics; Hyperlipidemia; Hypertension; Individual; Individual Differences; Instruction; Insulin Resistance; Investigation; Knowledge; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mediator of activation protein; Memory; Mentored Clinical Oncology Award; Mentored Clinical Scientist Award; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Modeling; Neurobiology; Neurologic; Neuropsychological Tests; Obesity; Pattern; Performance; Population; Population Study; Purpose; Recruitment Activity; Research; Research Personnel; Risk; Risk Factors; Sampling; System; Techniques; Testing; Time; Training; United States; Universities; Washington; age effect; age related; base; brain volume; career; cerebral atrophy; cerebrovascular; cognitive function; cohort; design; ethnic minority population; executive function; experience; hypercholesterolemia; neurobiological mechanism; neuroimaging; normal aging; novel; patient oriented research; performance tests; programs; research and development; skill acquisition; skills; white matter

DESCRIPTION (provided by applicant): This is an application for a Mentored Patient-Oriented Research Development Award (K23). The goal of the proposed project is to provide the Applicant with advanced skills needed to establish an independent program of research in cognitive aging using neuroimaging and epidemiological methodologies. The Applicant proposes a comprehensive training plan, combining didactic instruction with established researchers; formal coursework; participation in ongoing seminars at Columbia University; and applied training experiences with individual advisors. Specific training goals include advanced knowledge and skill acquisition in the neurobiological mechanisms of cognitive aging; potential mediators and moderators of cognitive aging, including cerebrovascular risk factors and cross-cultural issues; design, implementation, and statistical analysis of epidemiological studies; principles of magnetic resonance imaging (MRI) and advanced neuromorphometric analysis; and the responsible conduct of research. The training plan will be executed in coordination with a proposed study that utilizes data from the Washington Heights Inwood Columbia Aging Project (WHICAP), an ongoing NIA funded study (P01AG007232) of risk factors for dementia in a multiethnic population of older adults residing in northern Manhattan. Although the main goal of WHICAP is to elucidate risk factors of Alzheimer's disease, it does not explicitly characterize neuromorphology or cognition in individuals who do not develop dementia. The proposed study will address the determinants of neuromorphology and related cognitive profiles among approximately 700 older individuals in the WHICAP cohort with "normal" age-related cognitive function. The project will examine the association between chronological age and several measures of neuromorphology, including regional volumes, white matter hyperintensity burden, and a new multivariate approach for the characterization of age-associated patterns of gray and white matter. These measures will be related to baseline performance on neuropsychological tests and change in cognition following an 18-month period. A secondary goal will be to examine the mediating effect of cerebrovascular risk factors (i.e., hypertension, insulin resistance, obesity, and hypercholesterolemia) and ethnic group differences on neuromorphology. The proposed project aims will therefore elucidate neurobiological changes associated with aging and will serve as a bridge for the Applicant to establish an independent investigator career in conducting large- scale neuromorphometry studies on clinical populations.

描述（由申请人提供）：这是一份指导患者导向研究发展奖（K23）的申请。拟建项目的目标是为申请人提供所需的高级技能，使其能够利用神经影像学和流行病学方法建立一个独立的认知衰老研究项目。申请人提出一个综合的培训计划，将教学指导与现有的研究人员相结合；正式的课程;参加哥伦比亚大学正在举行的讨论会；并与个别顾问应用培训经验。具体培训目标包括认知衰老神经生物学机制的高级知识和技能习得；认知衰老的潜在调节因子，包括脑血管危险因素和跨文化问题流行病学研究的设计、实施和统计分析；核磁共振成像（MRI）原理和高级神经形态计量学分析；以及负责任的研究行为。培训计划将与一项拟议研究协调执行，该研究利用了华盛顿高地Inwood哥伦比亚老龄化项目(该项目是一项正在进行的NIA资助的研究（P01AG007232）的数据，研究居住在曼哈顿北部的多种族老年人痴呆症的危险因素。尽管该研究的主要目标是阐明阿尔茨海默病的危险因素，但它并没有明确描述未发生痴呆的个体的神经形态或认知特征。这项拟议的研究将解决大约700名老年人的神经形态和相关认知特征的决定因素，这些老年人在与年龄相关的认知功能“正常”的队列中。该项目将研究实足年龄与若干神经形态学指标之间的关系，包括区域容量、白质高强度负担，以及一种新的多变量方法来表征灰质和白质的年龄相关模式。这些措施将与18个月后神经心理测试的基线表现和认知变化有关。第二个目标将是检查脑血管危险因素（即高血压、胰岛素抵抗、肥胖和高胆固醇血症）和种族差异对神经形态的中介作用。因此，拟议的项目旨在阐明神经生物学的变化