NEI Institute Clinical Scientist Development Program

描述(由申请人提供)：这是一份机构培训拨款提案，旨在培养下一代临床医生-科学家在眼科的学术职位。38年来，杜克大学眼科中心(DUEC)在培养学术眼科医生方面一直处于全国领先地位。这些学员中最早的几代人现在在国内外学术医学中心的许多领导职位上任职。他们担任院长、系主任和教职员工，并担任院士的导师。我们建议通过一个密集的计划来延续这一传统，旨在提供必要的指导、资源和授课教学，以培养眼科学术职位的临床医生-科学家。我们计划每年在完成眼科或病理学住院医师后挑选两名实习生参加为期3年的高强度教育计划，这将导致独立的同行评审拨款和学术机构的教员职位。受训者将接受密集的教学课程，并接受杜克大学资深教师的密切指导。每个受训人员将接受临床研究、遗传学、统计学、科学写作、拨款准备、伦理和负责任的研究行为等领域的强制性培训。每个学员都将参与重要的原创性研究，并学习发展成功和独立的学术生涯所需的基本技能。每个学员课程的其他方面将由项目主任和首席导师根据选定的主要研究方向及其技能、背景和职业目标进行定制。我们提出了五个主要研究方向：1)眼科基因组学和蛋白质组学，2)眼科病理学，3)转化医学和临床试验，4)临床到工作台，5)结果和卫生政策。由于国际上缺乏参与研究的眼科病理学家，我们将尝试招聘病理学家，并为他们的研究生涯培训他们，以利用从患者和实验模型中提取的组织来进一步了解眼病。

DESCRIPTION (provided by applicant): This is an institutional training grant proposal to educate the next generation of clinician-scientists for academic positions in Ophthalmology. For over 38 years, the Duke University Eye Center (DUEC) has been a national leader in training academic Ophthalmologists. The earliest generations of these trainees now serve in numerous leadership positions in academic medical centers across the country and abroad. They have roles as Deans, Department Chairs, and faculty members and serve as mentors for academicians. We propose to continue this tradition through an intensive program designed to provide the guidance, resources, and didactic teaching necessary to produce clinician-scientists for academic positions in Ophthalmology. We plan to select two trainees each year after their completion of a residency in Ophthalmology or Pathology for an intense 3 year educational program that will lead to independent peer-reviewed grant funding and a faculty position in an academic institution. The trainees will undergo an intensive didactic curriculum combined with a close mentorship by senior faculty at Duke University. Each trainee will receive mandatory training in areas of clinical research, genetics, statistics, scientific writing, grant preparation, ethics, and the responsible conduct of research. Each trainee will participate in significant original research and learn the essential skills to develop a successful and independent academic career. Additional aspects of the curriculum of each trainee will be tailored by the program director and lead mentor based upon the selected primary research track and his/her skills, background and career goals. We propose five primary research tracks: 1) Ophthalmic Genomics and Proteomics, 2) Ophthalmic Pathology, 3) Translational Medicine and Clinical Trials, 4) Clinic to Bench, 5) Outcomes and Health Policy. Because of an international shortage of Ophthalmic Pathologists involved in research, we will attempt to recruit Pathologists and train them for a research career to further knowledge about ocular diseases using tissue derived from patients and experimental models.