Child Health Research Career Development Award

描述（由申请人提供）：哥伦布儿童医院儿童健康研究中心职业发展奖（CHRCDA）的长期目标是培养新一代儿科实验室科学家，该奖项设在俄亥俄州立大学医学院儿科学系。本次续展申请，我们延续了我们现有CHRCDA的主题，即儿科分子医学。在精心挑选的经验丰富的专业导师的指导下，我们建议继续培养最高水平的儿科医师学者，准备在儿童疾病的预防和治疗方面带来分子医学的最新进展。在我们CHRCDA的9年生命周期中，我们以高于全国同行CHRCDA机构平均水平的速度将学者转移到独立的联邦资助。学员发表学术论文118篇，82%留在学术界。有一位学者是一个未被充分代表的少数派。其中45%是女性，超过了全国平均水平。在这一成功记录的基础上，在当前的应用中，我们扩大了经验丰富的调查员/导师队伍，并提出了一个独特的、强化的指导计划，远远超出了提供实际的实验室经验。在人类疾病生物学、实验设计、资助和研究伦理方面提供正式的教学和小组项目，以支持学者向独立的过渡。CHRCDA由一名首席研究员、一名项目主管、一名招聘人员和专家内部和外部咨询委员会监督。27名基础实验室科学家热情地同意担任导师。哥伦布儿童研究所（Columbus Children's research Institute）的研究环境从未如此强大，2005年至2010年间，该研究所计划在研究项目和基础设施方面投资2亿美元。我们机构的儿科奖学金项目持续增长，外部候选人的招聘也在快速进行，确保了招募学者的人才渠道持续不断。因此，我们的理想定位是延长我们成功的CHRCDA，以获得额外的支持。

DESCRIPTION (provided by applicant): The long-term objective of the Columbus Children's Hospital Child Health Research Center Career Development Award (CHRCDA), based in the Department of Pediatrics at The Ohio State University College of Medicine, is to train a new generation of pediatric laboratory scientists. For this renewal application, we continue the theme of our existing CHRCDA, that is, molecular medicine in pediatrics. Under the guidance of a carefully selected, experienced faculty of dedicated mentors, we propose to continue training pediatric physician scholars of the highest caliber, poised to bring to bear the latest advances in molecular medicine on the prevention and healing of childhood disease. Over the 9 year lifetime of our CHRCDA, we have transitioned scholars to independent federal funding at a rate above the national average for peer CHRCDA institutions. Our trainees have published 118 scholarly publications and 82% remain in academia. One scholar has been an underrepresented minority. Forty-five percent have been women, exceeding the national average. Building on this record of success, in the current application we have expanded our cadre of Experienced Investigators/Mentors and propose a unique, intensified mentoring program that extends far beyond provision of a hands-on laboratory experience. Formal didactic and small group programs in the biology of human disease, experimental design, grantsmanship, and research ethics are offered in support of transition of scholars to independence. The CHRCDA is overseen by a Principal Investigator, a Program Director, a Recruiter, and expert internal and external advisory committees. Twenty seven basic laboratory scientists have enthusiastically agreed to serve as mentors. The research environment at Columbus Children's Research Institute has never been stronger, with a $200 million investment in research programs and infrastructure planned between 2005 and 2010. Pediatric fellowship programs continue to grow at our institution and recruitment of external candidates continues apace, ensuring an ongoing pipeline of talent from which to recruit scholars. Thus, we are ideally positioned to extend our successful CHRCDA for an additional interval of support.