Child Health Research Career Development Award

儿童健康研究职业发展奖

• 批准号: 8197129
• 负责人: Michael Thomas Brady
• 金额: $ 31.58万
• 依托单位: RESEARCH INST NATIONWIDE CHILDREN'S HOSP
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-11 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8197129
• 关键词: Academia; Advisory Committees; Biology; Caliber; Child; Child health care; Childhood; Disease; Ensure; Environment; Experimental Designs; Faculty; Fellowship Program; Funding; Generations; Healed; Institution; Investments; K-Series Research Career Programs; Laboratories; Laboratory Scientists; Medicine; Mentors; Molecular Medicine; Ohio; Pediatric Hospitals; Pediatrics; Physicians; Positioning Attribute; Prevention; Principal Investigator; Publications; Publishing; Recruitment Activity; Research; Research Ethics; Research Infrastructure; Research Institute; Research Personnel; Talents; Training; Underrepresented Minority; Universities; Ursidae Family; Woman; base; college; experience; healing; human disease; pediatric department; peer; programs; success

The long-term objective of the Columbus Children's Hospital Child Health Research Center Career Development Award (CHRCDA), based in the Department of Pediatrics at The Ohio State University College of Medicine, is to train a new generation of pediatric laboratory scientists. For this renewal application, we continue the theme of our existing CHRCDA, that is, molecular medicine in pediatrics. Under the guidance of a carefully selected, experienced faculty of dedicated mentors, we propose to continue training pediatric physician scholars of the highest caliber, poised to bring to bear the latest advances in molecular medicine on the prevention and healing of childhood disease. Over the 9 year lifetime of our CHRCDA, we have transitioned scholars to independent federal funding at a rate above the national average for peer CHRCDA institutions. Our trainees have published 118 scholarly publications and 82% remain in academia. One scholar has been an underrepresented minority. Forty-five percent have been women, exceeding the national average. Building on this record of success, in the currrent application we have expanded our cadre of Experienced Investigators/Mentors and propose a unique, intensified mentoring program that extends far beyond provision of a hands-on laboratory experience. Formal didactic and small group programs in the biology of human disease, experimental design, grantsmanship, and research ethics are offered in support of transition of scholars to independence. The CHRCDA is overseen by a Principal Investigator, a Program Director, a Recruiter, and expert internal and external advisory committees. Twenty seven basic laboratory scientists have enthusiastically agreed to serve as mentors. The research environment at Columbus Children's Research Institute has never been stronger, with a $200 million investment in research programs and infrastructure planned between 2005 and 2010. Pediatric fellowship programs continue to grow at our instiution and recruitment of external candidates continues apace, ensuring an ongoing pipeline of talent from which to recruit scholars. Thus, we are ideally positioned to extend our successful CHRCDA for an additional interval of support.

哥伦布儿童医院儿童健康研究中心职业生涯的长期目标 发展奖(CHRCDA)，设在俄亥俄州立大学学院儿科 医学，就是要培养新一代儿科实验室科学家。对于此续期申请，我们 延续我们现有CHRCDA的主题，即儿科分子医学。在…的指导下 经过精心挑选、经验丰富的专职导师，我们建议继续培训儿科 最高水平的内科学者，准备带来分子医学的最新进展 关于儿童疾病的预防和治疗。 在我们CHRCDA的9年生命中，我们已经将学者过渡到独立的联邦资助机构 这一比率高于全国同行CHRCDA机构的平均水平。我们的学员已经发表了118篇学术论文 出版物和82%的人仍留在学术界。一位学者一直是代表不足的少数群体。四十五岁 女性所占比例超过了全国平均水平。在此成功记录的基础上，在 目前，我们已扩大了经验丰富的调查人员/导师队伍，并提出了 独特的强化指导计划，远远超出了提供动手实验室的范围 经验。人类疾病生物学的正式教学和小组项目，实验性 提供设计、专家精神和研究伦理，以支持学者向独立的过渡。 CHRCDA由一名首席调查员、一名计划主任、一名招聘人员和专家内部人员监督 和外部咨询委员会。27名基础实验室科学家热情地同意 充当导师。哥伦布儿童研究所的研究环境从未像现在这样 更强大，计划在2005至2005年间在研究项目和基础设施方面投资2亿美元 2010年。儿科奖学金计划在我们的培训和招募外部候选人的过程中继续增长 继续快速发展，确保了持续不断的人才管道，从那里招聘学者。因此，理想情况下，我们是 定位于将我们成功的CHRCDA延长一段时间的支持。

项目成果

Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity.

• DOI: 10.1016/j.freeradbiomed.2010.07.016
• 发表时间: 2010-11-15
• 期刊: FREE RADICAL BIOLOGY AND MEDICINE
• 影响因子: 7.4
• 作者: Farrell, Michael R.;Rogers, Lynette K.;Liu, Yusen;Welty, Stephen E.;Tipple, Trent E.
• 通讯作者: Tipple, Trent E.

MAPK signaling drives inflammation in LPS-stimulated cardiomyocytes: the route of crosstalk to G-protein-coupled receptors.

• DOI: 10.1371/journal.pone.0050071
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Frazier WJ;Xue J;Luce WA;Liu Y
• 通讯作者: Liu Y

Rapid fluid resuscitation in pediatrics: testing the American College of Critical Care Medicine guideline.

儿科快速液体复苏：测试美国重症监护医学会指南。

• DOI: 10.1016/j.annemergmed.2007.06.482
• 发表时间: 2007
• 期刊: Annals of emergency medicine
• 影响因子: 6.2
• 作者: Stoner,MichaelJ;Goodman,DeborahG;Cohen,DanielM;Fernandez,SoledadA;Hall,MarkW
• 通讯作者: Hall,MarkW

Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome.

• DOI: 10.1007/s00134-010-2088-x
• 发表时间: 2011-03
• 期刊: Intensive care medicine
• 影响因子: 38.9
• 作者: Hall MW;Knatz NL;Vetterly C;Tomarello S;Wewers MD;Volk HD;Carcillo JA
• 通讯作者: Carcillo JA

Cardiac teratogenicity in mouse maternal phenylketonuria: defining phenotype parameters and genetic background influences.

• DOI: 10.1016/j.ymgme.2012.08.001
• 发表时间: 2012-12
• 期刊: MOLECULAR GENETICS AND METABOLISM
• 影响因子: 3.8
• 作者: Seagraves, Nikki J.;McBride, Kim L.
• 通讯作者: McBride, Kim L.