Neurobiological Aspects of Aging

描述（由申请人提供）：该指导临床科学家发展计划的目的是支持在与衰老相关的神经科学学科中的优秀实习医生的职业发展，从而实现研究的独立性。培训将作为一个联合项目进行，利用当地神经科学界的各种广泛资源，包括加州大学圣地亚哥分校，斯克里普斯研究基金会，索尔克研究所和伯纳姆基金会。该计划的优秀申请人将从UCSD神经科学系临床神经病学计划的毕业居民和全国神经病学培训计划中招募。每年申请1个名额，为期5年，共5个培训职位。该计划将由神经科学系管理，这是一个联合基础科学-临床部门。该学院在神经系统衰老研究的遗传，分子，细胞，系统，行为和建模方面具有相当的实力。该学院还积极从事转化研究，从而直接影响人类疾病的治疗。培训计划将为被任命者提供三种类型的学术经验 研究独立性：1）基础神经科学培训，通过正式的神经科学研究生课程和实验室研究轮换完成，2）3-4年的密集指导研究，以及3）研讨会，老化课程和讲座的连续课程。没有博士学位的学员。学位将有机会参加UCSD神经科学研究生课程并获得神经科学博士学位培训计划旨在使学员接触到广泛的神经科学主题，这些主题是从全面和学术Vantage来处理与衰老相关的问题所必需的，从基因表达的研究到整个系统/行为方法。然后，个别学员将选择一个学科，在其中重点和促进职业研究课题。

DESCRIPTION (provided by applicant): The purpose of this Mentored Clinical Scientist Development Program is to support the career development of outstanding physician trainees in an aging-related neuroscience discipline, leading-to-research independence. Training will be conducted as a joint program taking advantage of the diverse and extensive resources of the local neuroscience community, including the University of California-San Diego, Scripps Research Foundation, the Salk Institute, and the Burnham Foundation. Outstanding applicants for the program will be recruited both locally from graduating residents of the clinical neurology program in the Department of Neurosciences at UCSD, and from neurology training programs nationally. 1 slot per year is requested for a 5 year period, totaling 5 training positions. The program will be administered by the Department of Neurosciences, a joint basic science-clinical department. The faculty possesses considerable strength in the genetic, molecular, cellular, systems, behavioral and modeling aspects of nervous system aging research. The faculty are also active in translational research, thereby directly impacting the treatment of human disease. The training program will provide appointees three types of academic experiences to lead to research independence: 1) Basic neuroscience training, accomplished by formal Neuroscience Graduate Program course work and laboratory research rotations, 2) a 3-4 year period of intensive mentored research, and 3) a continuous curriculum of symposia, coursework in aging, and lectures. Trainees who do not have a Ph.D. degree will have the opportunity to enroll in the UCSD Neuroscience Graduate Program and earn a Neuroscience doctoral degree The training program intends to expose the trainees to a breadth of neuroscience topics that are required to approach aging-related questions from a comprehensive and scholarly vantage point, ranging from the study of gene expression to whole systems/behavioral approaches. Individual trainees will then choose a discipline within which to focus and foster a career research topic.