Boston OAIC: A Translational Approach to Function Promoting Anabolic Therapies

描述(由申请人提供)：老年人的功能衰退和依赖预示着不良的结果，并对医疗保健服务和成本施加巨大的负担。因此，功能促进合成代谢疗法(FPAT)可以改善身体功能，减轻残疾功能限制的负担，是可取的。波士顿克劳德·A·佩珀老年美国人独立中心(OAIC)以功能限制和FPAT为主题，将把NIH资助的13项研究、4项创新试点项目和2项发展项目整合到一个有凝聚力的跨学科项目中，该项目由领导力和行政核心--研究--支持 职业发展核心(RCDC)，一个试点和探索性研究SxCore，以及三个资源核心 (功能评估核心、肌肉祖细胞核心和系统生物学核心)。波士顿OAIC在整个翻译发现研究领域中的定位是独一无二的：13个OAIC项目以及试点和开发项目将阐明FPAT作用的功能限制和机制的流行病学，帮助确定FPAT发现的目标和FPAT作用的生物标记物，并促进领先的FPAT的方法开发、结果验证和疗效试验。RCDC将从几个学科中招募最好的候选人，包括老年病学和老年学，并通过结构化的教学教育和指导性研究计划对他们进行培训。OAIC的整合将通过每周跨学科研究会议、一年两次的务虚会、一个网站、共同的主题重点和旨在促进合作的促进计划来实现。OAIC活动的社区推广和传播将通过大使计划实现，该计划将组织社区活动、时事通讯和社区咨询委员会。OAIC的独特优势包括专注于FPATs，重视创新，其覆盖了从机制阐明到疗效试验的整个转化研究范围，其成员之间富有成效的合作历史，强大的基础设施和机构承诺，包括几项重要的流行病学调查(FHS、MMAS、BACH、百岁研究和BOKS)、FPAT干预试验，以及基于机制的FPAT发现。波士顿OALC的合作战略应该有助于加快将研究成果转化为基于证据的FPAT，并培养新一代老龄化研究人员。 计划作为一个整体

DESCRIPTION (provided by applicant): Functional decline and dependence in older individuals portend poor outcome, and impose a large burden on health care services and costs. Therefore, function promoting anabolic therapies (FPATs) that improve physical function and reduce the burden of disabling functional limitations are desirable. The Boston Claude A. Pepper Older Americans Independence Center (OAIC) with its thematic focus on functional limitations and FPATs will integrate 13 NIH-funded studies, 4 innovative pilot projects, and 2 developmental projects into a cohesive interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Career Development Core (RCDC), a Pilot and Exploratory StudieSxCore, and three resource cores (Function Assessment Core, Muscle Progenitor Cell Core, and Systems Biology Core). The Boston OAIC is unique in its positioning across the entire spectrum of translational discovery research: 13 OAIC projects, and pilot and developmental projects will elucidate the epidemiology of functional limitations and mechanisms of FPAT action, help identify targets for FPAT discovery and biomarkers of FPAT action, and facilitate methods development, outcomes validation, and efficacy trials of leading FPATs. The RCDC will recruit the best candidates from several disciplines, induing Geriatrics and Gerontology, and train them through a structured didactic education and mentored research program. Integration across OAIC will be achieved by weekly interdisciplinary research meetings, biannual retreats, a website, common thematic focus, and the PROMOTE program aimed at promoting collaboration. Community outreach and dissemination of OAIC activities will be achieved through Ambassador's Program which will organize community events, a newsletter, and a Community Advisory Board. Unique strengths of OAIC include its focus on FPATs, emphasis on innovation, its extension across entire spectrum of translational research from mechanism elucidation to efficacy trials, a history of productive collaborations among its members, strong infrastructure and institutional commitment, and inclusion of several important epidemiologic investigations (FHS, MMAS, BACH, Centenarian Study, and BOKS), FPAT intervention trials, and mechanism-based FPAT discoveries. Boston OAlC's collaborative strategies should help expedite the translation of research results into evidence-based FPATs and nurture a new generation of aging researchers. PROGRAM AS A WHOLE