Boston OAIC: A Translational Approach to Function Promoting Anabolic Therapies

波士顿 OAIC：促进合成代谢疗法功能的转化方法

• 批准号: 7413824
• 负责人: SHALENDER BHASIN
• 金额: $ 113.4万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7413824
• 关键词: Boston; OAIC; Translational; Approach; Function

DESCRIPTION (provided by applicant): Functional decline and dependence in older individuals portend poor outcome, and impose a large burden on health care services and costs. Therefore, function promoting anabolic therapies (FPATs) that improve physical function and reduce the burden of disabling functional limitations are desirable. The Boston Claude A. Pepper Older Americans Independence Center (OAIC) with its thematic focus on functional limitations and FPATs will integrate 13 NIH-funded studies, 4 innovative pilot projects, and 2 developmental projects into a cohesive interdisciplinary program that is supported by a Leadership and Administrative Core, a Research Career Development Core (RCDC), a Pilot and Exploratory StudieSxCore, and three resource cores (Function Assessment Core, Muscle Progenitor Cell Core, and Systems Biology Core). The Boston OAIC is unique in its positioning across the entire spectrum of translational discovery research: 13 OAIC projects, and pilot and developmental projects will elucidate the epidemiology of functional limitations and mechanisms of FPAT action, help identify targets for FPAT discovery and biomarkers of FPAT action, and facilitate methods development, outcomes validation, and efficacy trials of leading FPATs. The RCDC will recruit the best candidates from several disciplines, induing Geriatrics and Gerontology, and train them through a structured didactic education and mentored research program. Integration across OAIC will be achieved by weekly interdisciplinary research meetings, biannual retreats, a website, common thematic focus, and the PROMOTE program aimed at promoting collaboration. Community outreach and dissemination of OAIC activities will be achieved through Ambassador's Program which will organize community events, a newsletter, and a Community Advisory Board. Unique strengths of OAIC include its focus on FPATs, emphasis on innovation, its extension across entire spectrum of translational research from mechanism elucidation to efficacy trials, a history of productive collaborations among its members, strong infrastructure and institutional commitment, and inclusion of several important epidemiologic investigations (FHS, MMAS, BACH, Centenarian Study, and BOKS), FPAT intervention trials, and mechanism-based FPAT discoveries. Boston OAlC's collaborative strategies should help expedite the translation of research results into evidence-based FPATs and nurture a new generation of aging researchers. PROGRAM AS A WHOLE

描述（由申请人提供）：老年人的功能衰退和依赖预示着不良结局，并对医疗保健服务和成本造成巨大负担。因此，需要改善身体功能并减少功能限制的负担的功能促进合成代谢疗法（FPAT）。波士顿克劳德A. Pepper老年美国人独立中心（OAIC）以其功能限制和FPAT为主题，将13项NIH资助的研究，4项创新试点项目和2项发展项目整合为一个有凝聚力的跨学科计划，该计划由领导和行政核心，研究和管理核心， 职业发展核心（RCDC），一个试点和探索性研究SxCore，以及三个资源核心 （功能评估核心，肌肉祖细胞核心和系统生物学核心）。波士顿OAIC在整个转化发现研究领域的定位是独一无二的：13个OAIC项目，以及试点和发展项目将阐明FPAT作用的功能限制和机制的流行病学，帮助确定FPAT发现的目标和FPAT作用的生物标志物，并促进方法开发，结果验证和领先FPAT的有效性试验。RCDC将从几个学科中招募最好的候选人，包括老年医学和老年学，并通过结构化的教学教育和指导研究计划对他们进行培训。OAIC的整合将通过每周跨学科研究会议、一年两次的务虚会、网站、共同主题焦点以及旨在促进合作的PROMOTE计划来实现。将通过大使方案组织社区活动、一份通讯和一个社区咨询委员会来实现社区外展和传播OAIC活动。OAIC的独特优势包括其对FPAT的关注，强调创新，从机制阐明到功效试验的整个转化研究范围的扩展，其成员之间富有成效的合作历史，强大的基础设施和机构承诺，以及包括几项重要的流行病学调查（FHS，MMAS，BACH，百岁老人研究和BOKS），FPAT干预试验和基于机制的FPAT发现。波士顿OAlC的合作策略应该有助于加快将研究成果转化为基于证据的FPAT，并培养新一代的老龄化研究人员。 整个程序