Boston OAIC: A Translational Approach to Function Promoting Therapies

项目摘要 这一多样性补充的目的是支持博士的研究、培训和职业发展。 罗德里戈·瓦尔德拉巴诺，一位杰出的少数民族内科科学家。这份多样性副刊链接到 波士顿老年美国人独立中心(OAIC)的研究教育核心，以及 NIA资助的P30赠款(P30AG013679；PI：Shalender Bhasin)，其主要目标是培养未来的独立 研究科学家，他们拥有将疾病的基本机制和 将老龄化过程中的残疾转化为新的干预措施，可以改善健康、身体功能和 人们随着年龄增长的幸福感。波士顿OAIC的赠款最近被续期5年，即 足以支持补编中提出的要求的两年研究。有指导的研究 该项目在主题上也与OAIC对促进功能的疗法、衰老机制和 老年学目标，以及sirtuin-NAD通路在衰老和先天免疫反应中的作用。这个 多样性补充有两个密切相关的组成部分： 补充目标1：在沙伦德博士的指导下进行为期两年的强化指导研究培训 Bhasin在烟酰胺腺嘌呤二核苷酸(NAD)在脑内的作用的观察性研究 调节SARS-CoV-2感染的先天免疫应答和严重程度及其与机体免疫功能的关系 新冠肺炎急性后遗症的发展，也称为慢性COVID综合征。 补充目标2：与培训计划很好地结合在一起的有组织的、个性化的、指导性的培训 波士顿胡椒中心的研究教育核心。 Valderrábano博士将与他的导师一起制定个性化培训计划(IDP)，如 求婚。该计划将由区域经济委员会主任刘易斯·利普西茨博士审查和批准。IdP包括 以下类别：1)职业和学习目标，2)负责任的研究培训行为，3) 课程作业，4)科学会议和会议，5)职业发展，6)论文和摘要， 7)助学金申请/S。授课培训包括参加波士顿OACI的教育活动 REC获奖者，高级老龄化研究研讨会系列(AARTSS)，制定有组织的活动 手稿和助学金的写作技巧，OMICS原理和统计分析的课程作业 口译。他还将出席OAIC，男性健康计划的定期研究会议，以及 格伦衰老生物学中心。拟议的研究、培训和职业发展将 促进Valderrábano博士迈向衰老方面的独立研究生涯。

Project Summary The objective of this Diversity Supplement is to support the research training and career development of Dr. Rodrigo Valderrábano, an outstanding minority physician scientist. This Diversity Supplement is linked to the Research Education Core of the Boston Claude D. Pepper Older Americans Independence Center (OAIC), an NIA-funded P30 grant (P30AG013679; PI: Shalender Bhasin), whose primary aim is to train future independent research scientists who have the knowledge and skills to translate fundamental mechanisms of disease and disability during the aging process into novel interventions that can improve the health, physical function, and well-being of people as they age. The Boston OAIC grant was recently renewed for a period of 5 years which is sufficient to support the requested 2 years of research proposed in the supplement. The mentored research project also is thematically linked to OAIC's focus on function promoting therapies, mechanisms of aging and geroscience targets, and the role of the sirtuin-NAD pathway in aging and innate immune response. The Diversity Supplement has two closely linked components: Supplement Aim 1: A 2-year intensive mentored research training under the supervision of Dr. Shalender Bhasin in the context of an observational study of the role of nicotinamide adenine dinucleotide (NAD) in modulating the innate immune response and severity of SARS-CoV-2 infection and its relation to the development of the post-acute sequelae of COVID-19 (PASC), also known as chronic COVID syndrome. Supplement Aim 2: A structured, individually-tailored, didactic training well integrated with the training program of the Boston Pepper Center's Research Education Core. Dr. Valderrábano will work with his mentor in developing an individualized training plan (IDP) as outlined in the proposal. This plan will be reviewed and approved by the REC Director, Dr. Lewis Lipsitz. The IDP includes the following categories: 1) Career and Learning Goals, 2) Responsible Conduct of Research Training, 3) Coursework, 4) Scientific Meetings and Conferences, 5) Professional Development, 6) Papers and Abstracts, and 7) Grant application/s. Didactic training includes participating in Boston OACI's educational activities for REC awardees, Advanced Aging Research Seminar Series (AARTSS), structured activities to develop manuscript and grant writing skills, coursework in ‘OMICS Principles, and Statistical Analysis and Interpretation. He also will attend the regular research conferences of the OAIC, Men's Health program, and the Glenn Center for the Biology of Aging. The proposed research training and career development will facilitate Dr. Valderrábano's advancement towards an independent research career in aging.