Boston OAIC: A Translational Approach to Function Promoting Therapies

波士顿 OAIC：功能促进疗法的转化方法

• 批准号: 10569992
• 负责人: SHALENDER BHASIN
• 金额: $ 2.92万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10569992
• 关键词: Age; Aging; American; Applications Grants; Biology of Aging; Boston; COVID-19 severity; Cancer Grant Supplements (P30); Capsicum; Categories; Development; Disease; Educational Activities; Funding; Future; Geroscience; Goals; Grant; Health; Individual; Innate Immune Response; Intervention; Knowledge; Learning; Link; Long COVID; Manuscripts; Mentors; Minority; Nicotinamide adenine dinucleotide; Observational Study; Paper; Pathway interactions; Personal Satisfaction; Persons; Physical Function; Physicians; Post-Acute Sequelae of SARS-CoV-2 Infection; Process; Research; Research Project Grants; Research Support; Research Training; Role; SARS-CoV-2 infection; Scientist; Series; Sirtuins; Statistical Data Interpretation; Structure; Supervision; Syndrome; Training; Training Programs; Translating; Work; Writing; career; career development; disability; education research; improved; male health; meetings; novel; programs; responsible research conduct; skills; symposium; translational approach

Project Summary The objective of this Diversity Supplement is to support the research training and career development of Dr. Rodrigo Valderrábano, an outstanding minority physician scientist. This Diversity Supplement is linked to the Research Education Core of the Boston Claude D. Pepper Older Americans Independence Center (OAIC), an NIA-funded P30 grant (P30AG013679; PI: Shalender Bhasin), whose primary aim is to train future independent research scientists who have the knowledge and skills to translate fundamental mechanisms of disease and disability during the aging process into novel interventions that can improve the health, physical function, and well-being of people as they age. The Boston OAIC grant was recently renewed for a period of 5 years which is sufficient to support the requested 2 years of research proposed in the supplement. The mentored research project also is thematically linked to OAIC's focus on function promoting therapies, mechanisms of aging and geroscience targets, and the role of the sirtuin-NAD pathway in aging and innate immune response. The Diversity Supplement has two closely linked components: Supplement Aim 1: A 2-year intensive mentored research training under the supervision of Dr. Shalender Bhasin in the context of an observational study of the role of nicotinamide adenine dinucleotide (NAD) in modulating the innate immune response and severity of SARS-CoV-2 infection and its relation to the development of the post-acute sequelae of COVID-19 (PASC), also known as chronic COVID syndrome. Supplement Aim 2: A structured, individually-tailored, didactic training well integrated with the training program of the Boston Pepper Center's Research Education Core. Dr. Valderrábano will work with his mentor in developing an individualized training plan (IDP) as outlined in the proposal. This plan will be reviewed and approved by the REC Director, Dr. Lewis Lipsitz. The IDP includes the following categories: 1) Career and Learning Goals, 2) Responsible Conduct of Research Training, 3) Coursework, 4) Scientific Meetings and Conferences, 5) Professional Development, 6) Papers and Abstracts, and 7) Grant application/s. Didactic training includes participating in Boston OACI's educational activities for REC awardees, Advanced Aging Research Seminar Series (AARTSS), structured activities to develop manuscript and grant writing skills, coursework in ‘OMICS Principles, and Statistical Analysis and Interpretation. He also will attend the regular research conferences of the OAIC, Men's Health program, and the Glenn Center for the Biology of Aging. The proposed research training and career development will facilitate Dr. Valderrábano's advancement towards an independent research career in aging.

项目摘要 本多元化补充计划的目的是支持博士的研究培训及职业发展。 Rodrigo Valderrábano，一位杰出的少数民族医生科学家。这种多样性补充与 波士顿研究教育中心。Pepper Older Americans Independence Center（OAIC） NIA资助的P30赠款（P30 AG 013679; PI：Shalender Bhasin），其主要目的是培养未来的独立 研究科学家谁拥有的知识和技能，以翻译疾病的基本机制， 在老龄化过程中的残疾到新的干预措施，可以改善健康，身体功能， 随着年龄的增长，人们的幸福感。波士顿OAIC补助金最近更新了5年， 足以支持补充材料中提出的2年研究要求。指导研究 该项目还与OAIC的重点功能促进疗法，衰老机制和 老年科学的目标，以及sirtuin-NAD途径在衰老和先天免疫反应中的作用。的 多样性补充有两个密切相关的组成部分： 补充目标1：在Shalender博士的监督下进行为期2年的强化指导研究培训 在烟酰胺腺嘌呤二核苷酸（NAD）在 调节SARS-CoV-2感染的天然免疫应答和严重程度及其与 COVID-19急性后后遗症（PASC）的发展，也称为慢性COVID综合征。 补充目标2：与培训计划完美结合的结构化、个性化、教学式培训 波士顿胡椒中心的研究教育核心。 博士Valderrábano将与他的导师一起制定个性化的培训计划（IDP），如 提议该计划将由REC主任刘易斯利普西茨博士审查和批准。IDP包括 以下类别：1）职业和学习目标，2）负责任的研究培训行为，3） 课程作业，4）科学会议和会议，5）专业发展，6）论文和摘要， 及7）拨款申请。教学培训包括参加波士顿OACI的教育活动， REC获奖者，先进的老龄化研究研讨会系列（AARTSS），结构化的活动，以发展 手稿和赠款写作技巧，在'OMICS原则课程，统计分析和 口译。他还将参加OAIC的定期研究会议，男性健康计划， 格伦衰老生物学中心拟议的研究培训和职业发展将 促进Valderrábano博士在老龄化方面的独立研究事业的发展。