MOLECULAR SCIENCES RESOURCE CORE

分子科学研究核心(MSRC)代表着人类进化的自然进程 目前WFU OAIC基因组学和生物标志物核心。这个核心在以下方面发挥了不可或缺的作用 WFU OAIC通过提供科学专业知识和资源来评估统一的生物标志物电池 为了确定特定的生物和/或遗传因素是否可以预测骨质疏松症、体力活动减少 老年人的功能和/或残疾。这项工作的结果是提供洞察力的关键 这导致了OAIC的新主题。MSRC将通过提供和利用资源来继续这项工作， 提供科学专门知识，并提供教育和培训机会，以支持正在进行的和 符合WFU OAIC主题的新研究：整合影响身体机能的途径 残疾预防的新办法“。 提出的MSRC的总体科学假设是，特定的分子、生理和 组织学机制有助于与年龄相关的总脂肪和“异位”(异常位置)脂肪的增加， 从而导致肌肉质量和力量的丧失以及随后的身体功能下降，并且 这些因素的治疗性修饰可以减缓残疾的进展。MSRC将协助 WFU OAIC的翻译研究，为6项外部资助的研究、3项试点提供核心资源 在新周期的第一年，两个项目和2个研究开发项目。科学的 MSRC的目标是：1)确定循环和组织中特定脂肪因子和 其他潜在的衰老和疾病生物标志物与肌肉质量、总脂肪和异位脂肪有关， 测量老年人的身体功能和身体残疾；2)确定是否有特定的 行为和药物干预将改变循环和组织中脂肪因子和其他 老年个体潜在的衰老和疾病生物标记物；3)评估特定的遗传标记物 与WFU OAIC主题相关的临床和/或生物措施；以及4)开发 新的分析方法，应用现有的分子方法，并提供生物组织资源和援助 分析这些组织，以解决与WFU OAIC主题相关的新研究问题。此外, MSRC将对研究人员和OALC支持的初级教员进行方法论方面的教育和培训 以及用于研究分子、生物学和组织学机制和危险因素的技术；以及 提供教育机会(研讨会、座谈会)以促进翻译研究和交流 OALC支持的研究成果。

The Molecular Sciences Research Core (MSRC) represents a natural progression in the evolution of the current WFU OAIC Genomics and Biomarkers Core. This Core has played an integral role in the success of the WFU OAIC by providing scientific expertise and resources for assessing a uniform battery of biomarkers to determine whether specific biological and/or genetic factors are predictive of sarcopenia, reduced physical function, and/or disability in older individuals. The results from this work were pivotal in providing the insight that led to the new OAIC theme. The MSRC will continue this work by providing and leveraging resources, contributing scientific expertise, and offering educational and training opportunities to support ongoing and new research in line with the WFU OAIC theme of "Integrating pathways affecting physical function for new approaches to disability prevention". The overall scientific hypothesis of the proposed MSRC is that specific molecular, physiological, and histological mechanisms contribute to age-related increases in total and "ectopic" (abnormally located) fat, thereby resulting in loss of muscle mass and strength and subsequent decline in physical function, and that therapeutic modification of these factors can slow progression to disability. The MSRC will facilitate translational research in the WFU OAIC by providing Core resources for 6 externally-funded studies, 3 pilot projects and 2 Research Development Projects during the first year of the new cycle. The scientific objectives of the MSRC are: 1)To determine whether circulating and tissue levels of specific adipokines and other potential aging- and disease-biomarkers are associated with muscle mass, total and ectopic fat, measures of physical function, and physical disability in older individuals; 2) To determine whether specific behavioral and pharmacological interventions will modify circulating and tissue levels of adipokines and other potential aging and disease biomarkers in older individuals; 3) To evaluate whether specific genetic markers are associated with clinical and/or biological measures relevant to the WFU OAIC theme; and 4) To develop new assays, apply existing molecular methodologies, and provide a biological tissue resource and aid in analyzing these tissues to address novel research questions relevant to the WFU OAIC theme. In addition, the MSRC will educate and train research fellows and OAlC-supported junior faculty in the methodologies and techniques used for the study of molecular, biological, and histological mechanisms and risk factors; and provide educational opportunities (seminars, symposiums) to foster translational research and communication of OAlC-supported research findings.