INVESTIGATING FITNESS INTERVENTIONS IN THE ELDERLY

调查老年人的健身干预措施

• 批准号: 8167052
• 负责人: Barbara J Nicklas
• 金额: $ 4.15万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167052
• 关键词: Abdomen; Aerobic; Affect; Body Weight decreased; Caloric Restriction; Computer Retrieval of Information on Scientific Projects Database; Educational Intervention; Elderly; Exercise; Fatty acid glycerol esters; Funding; Goals; Grant; Institution; Intervention; Muscle; Obesity; Organ; Outcome; Participant; Pericardial body location; Randomized; Randomized Clinical Trials; Recommendation; Research; Research Personnel; Resources; Risk Factors; Skeletal Muscle; Source; Stimulus; Training; United States National Institutes of Health; Visceral; Walking; Woman; arm; cardiovascular disorder risk; design; fitness; men; response; sedentary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main goal of this study is to determine whether the amount of fat loss (achieved through controlled underfeeding) affects the magnitude of improvement in aerobic function (maximal aerobic capacity and endurance) in response to a standardized exercise training stimulus that follows current recommendations for older persons. Secondary goals are to examine whether fat loss is necessary to elicit improvement in specific cardiovascular disease (CVD) risk factors, and to examine whether improvements in functional and CVD risk factor outcomes are related to the degree of total fat loss, as well as to reductions in fat accumulation in skeletal muscle (inter-muscular fat) and surrounding visceral organs (abdominal visceral and pericardial fat). We will accomplish these goals by conducting a 3-arm, 5-month randomized, clinical trial in 180 older (65-79 yrs), obese (BMI=30-34.9 kg/m2), sedentary men and women. Participants will be randomized to an exercise training intervention (moderate-intensity treadmill walking, 4 d/wk) alone (EX Only), exercise with moderate caloric restriction (-250 kcal/d deficit) designed for low weight loss (EX+Low CR; ~4.5 kg weight loss), or exercise with intensive caloric restriction (-600 kcal/d deficit) designed for high weight loss (EX+High CR; ~10.9 kg weight loss.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 这项研究的主要目标是确定脂肪损失的量（通过受控不足的喂养实现）是否会影响有氧功能改善的大小（最大有氧运动能力和耐力），以响应标准化的运动训练刺激，该刺激遵循当前对老年人的建议。次要目标是检查脂肪流失是否需要提高特定心血管疾病（CVD）危险因素，并检查功能和CVD危险因素结果的改善是否与总脂肪流失程度以及减少骨骼肌肉（肌肉脂肪间脂肪（肌肉脂肪）和周围的脂肪的脂肪累积相关的程度有关。 我们将通过在180岁（65 - 79年），肥胖（BMI = 30-34.9 kg/m2），久坐的男性和女性中进行3臂，5个月的随机临床试验来实现这些目标。 Participants will be randomized to an exercise training intervention (moderate-intensity treadmill walking, 4 d/wk) alone (EX Only), exercise with moderate caloric restriction (-250 kcal/d deficit) designed for low weight loss (EX+Low CR; ~4.5 kg weight loss), or exercise with intensive caloric restriction (-600 kcal/d deficit) designed for high weight loss (EX+High CR; ~10.9 kg weight loss.