CLINICAL CORE

北卡罗来纳大学CFAR临床核心(核心C)的主要目标是促进和加强临床和 北卡罗来纳大学、家庭健康国际(FHI)和三角研究所的艾滋病毒/艾滋病翻译研究 (RTI)。核心C通过为在艾滋病毒临床和医疗领域建立的CFAR成员提供服务来实现这一目标 翻译研究，寻找和协助新的调查人员，包括有经验的艾滋病毒基础 新接触转译研究的科学家，新接触艾滋病毒/艾滋病的经验丰富的临床研究人员，特别是 初级调查人员在艾滋病毒研究领域站稳脚跟。C核心由约瑟夫·埃伦博士组成 (主任)、Prema Meneze女士(协理核心主任)、Sonia Napravnik博士(流行病学家)、Dr. Christopher Pilcher(核心调查员)，Evelyn Quinlivan博士(核心调查员)，兼职研究 协调员，两名全职研究助理，一名全职临床筛查员，一名兼职研究助理， 和两名兼职程序员/计算机专家。 提供的具体服务包括：协助设计、开发和实施临床和 翻译研究，包括主体确定、招募和同意、项目协调、获取 临床样本、数据库设计和管理；NIH拨款提交、IRB、GCRC和FDA 研究和孤儿药物应用支持；获得北卡罗来纳大学CFAR艾滋病毒/艾滋病临床研究 数据库(UNC CFAR-DB)和链接的标本储存库，包括1700多名同意的参与者 获取临床社会人口学面对面调查的综合数据，包括 详细的行为信息；获得北卡罗来纳大学急性艾滋病毒感染临床研究计划的专业知识 和数据；在北卡罗来纳大学CFAR的三个校区和从 在机构之外。Core C使用这些服务来支持包括艾滋病毒在内的各种研究 疫苗开发(AI46023，AI50246)，细胞免疫学(AI20288，GM67143)，艾滋病毒生物学 传播(DK49381)，急性艾滋病毒感染(MH68686)，V3(包膜)进化(AI44667)，艾滋病毒耐药性 (AI50845)，艾滋病毒预防(AI46749，MH69989)，以及抗逆转录病毒和其他艾滋病毒临床试验(AI25868)。 核心C通过建立CFAR范围内的CFAR，在艾滋病毒/艾滋病研究交流方面提供了领导 局域网(LAN)，全面的UNC CFAR-DB和链接标本储存库，每月一次 合作研究会议和一年一度的艾滋病研讨会。核心C加强医疗和医疗人员的培训 支持学生研究的研究生、博士后研究员和初级调查人员 项目、CFAR发展奖和K-23奖。核心C还帮助建立了高效的 与外部机构和行业的合作。与国际合作者的外联努力，以及 社区中的艾滋病毒调查人员、临床医生和艾滋病毒感染者正在进行中。

The primary goal of the UNC CFAR Clinical Core (Core C) is to facilitate and enhance clinical and translational HIV/AIDS research at UNC, Family Health International (FHI) and Research Triangle Institute (RTI). Core C accomplishes this goal by serving CFAR members who are established in HIV clinical and translational research and seeking out and assisting new investigators including experienced HIV basic scientists new to translational research, experienced clinical investigators new to HIV/AIDS and especially junior investigators establishing themselves in HIV research. Core C is composed of Dr. Joseph Eron (Director), Ms. Prema Menezes (Associate Core Director), Dr. Sonia Napravnik, (Epidemiologist), Dr. Christopher Pilcher (Core Investigator), Dr. Evelyn Quinlivan (Core Investigator), a part time study coordinator, two full time research assistants, one full-time clinic screener, a part time research assistant, and two part time programmers / computer specialists. Specific services offered include: assistance with design, development and conduct of clinical and translational studies including subject identification, recruitment and consent, project coordination, obtaining clinical samples, database design and management; NIH grant submission, IRB, GCRC and FDA investigational and orphan drug application support; access to the UNC CFAR HIV/AIDS Clinical Research Database (UNC CFAR-DB) and linked specimen repository including over 1700 consented participants to date; access to comprehensive data from the Clinical Socio-Demographic in-person survey including detailed behavioral information; access to the UNC Acute HIV Infection Clinical Research Program expertise and data; and access to HIV basic and clinical investigators on the three UNC CFAR campuses and from outside institutions. Core C has used these services to support a large variety of studies including HIV vaccine development (AI46023, AI50246), cellular immunology (AI20288, GM67143), the biology of HIV transmission (DK49381), acute HIV infection (MH68686), V3 (envelope) evolution (AI44667), HIV resistance (AI50845), HIV prevention (AI46749, MH69989), and antiretroviral and other HIV clinical trials (AI25868). Core C has provided leadership in HIV/AIDS Research communication by establishing a CFAR-wide local area network (LAN), the comprehensive UNC CFAR-DB and linked specimen repository, a monthly collaborative research meeting and a yearly AIDS symposium. Core C enhances training of medical and graduate students, post doctoral fellows and junior investigators as evidenced by support of student research projects, CFAR developmental awards and K-23 awards. Core C also helped establish productive collaborations with outside institutions and industry. Outreach efforts to international collaborators, and to HIV investigators, clinicians and HIV-infected individuals in the community are ongoing.