CLINICAL CORE

临床核心（Core C）的主要目标是促进和加强临床和 艾滋病毒/艾滋病转化研究，国际家庭健康组织（FHI）和三角研究所 （RTI）。核心C通过为在艾滋病毒临床和医学领域建立的CFAR成员提供服务来实现这一目标。 翻译研究，寻找和协助新的研究人员，包括有经验的艾滋病毒基本 科学家新的转化研究，经验丰富的临床研究人员新的艾滋病毒/艾滋病，特别是 在艾滋病研究中站稳脚跟的初级研究人员。核心C由Joseph Eron博士组成 （主任）、Prema Menezes女士（副核心主任）、Sonia Napravnik博士（流行病学家）、 Christopher Pilcher（核心研究者）、Evelyn Quinquiry博士（核心研究者），一项兼职研究 协调员，两名全职研究助理，一名全职临床筛选员，一名兼职研究助理， 和两名兼职程序员/计算机专家。 提供的具体服务包括：协助设计、开发和开展临床和 转化研究，包括受试者识别、招募和知情同意、项目协调、获得 临床样本、数据库设计和管理; NIH拨款提交、IRB、GCRC和FDA 研究和孤儿药申请支持;获得艾滋病毒/艾滋病临床研究中心 数据库（ECOCFAR-DB）和链接的标本库，包括1700多名同意的参与者， 日期;访问临床社会人口统计学面对面调查的综合数据，包括 详细的行为信息;获得艾滋病毒急性感染临床研究计划的专业知识 和数据;以及获得艾滋病毒基础和临床研究人员在三个艾滋病毒研究中心校园和来自 机构外。核心C已经使用这些服务来支持包括艾滋病毒在内的大量研究 疫苗开发（AI 46023，AI 50246），细胞免疫学（AI 20288，GM 67143），HIV生物学 传播（DK 49381）、急性HIV感染（MH 68686）、V3（包膜）进化（AI 44667）、HIV耐药性 （AI 50845）、HIV预防（AI 46749、MH 69989）和抗逆转录病毒和其他HIV临床试验（AI 25868）。 核心C通过建立一个全CFAR的艾滋病毒/艾滋病研究交流中心， 局域网（LAN），综合性的ECOCFAR-DB和链接的标本库，每月 合作研究会议和年度艾滋病专题讨论会。核心C加强医疗和 研究生、博士后研究员和初级研究员，这一点可以从学生研究的支持中得到证明 项目，CFAR发展奖和K-23奖。核心C还帮助建立了生产力 与外部机构和行业的合作。与国际合作者的外联努力， 艾滋病毒调查人员、临床医生和社区中的艾滋病毒感染者正在进行中。

The primary goal of the UNC CFAR Clinical Core (Core C) is to facilitate and enhance clinical and translational HIV/AIDS research at UNC, Family Health International (FHI) and Research Triangle Institute (RTI). Core C accomplishes this goal by serving CFAR members who are established in HIV clinical and translational research and seeking out and assisting new investigators including experienced HIV basic scientists new to translational research, experienced clinical investigators new to HIV/AIDS and especially junior investigators establishing themselves in HIV research. Core C is composed of Dr. Joseph Eron (Director), Ms. Prema Menezes (Associate Core Director), Dr. Sonia Napravnik, (Epidemiologist), Dr. Christopher Pilcher (Core Investigator), Dr. Evelyn Quinlivan (Core Investigator), a part time study coordinator, two full time research assistants, one full-time clinic screener, a part time research assistant, and two part time programmers / computer specialists. Specific services offered include: assistance with design, development and conduct of clinical and translational studies including subject identification, recruitment and consent, project coordination, obtaining clinical samples, database design and management; NIH grant submission, IRB, GCRC and FDA investigational and orphan drug application support; access to the UNC CFAR HIV/AIDS Clinical Research Database (UNC CFAR-DB) and linked specimen repository including over 1700 consented participants to date; access to comprehensive data from the Clinical Socio-Demographic in-person survey including detailed behavioral information; access to the UNC Acute HIV Infection Clinical Research Program expertise and data; and access to HIV basic and clinical investigators on the three UNC CFAR campuses and from outside institutions. Core C has used these services to support a large variety of studies including HIV vaccine development (AI46023, AI50246), cellular immunology (AI20288, GM67143), the biology of HIV transmission (DK49381), acute HIV infection (MH68686), V3 (envelope) evolution (AI44667), HIV resistance (AI50845), HIV prevention (AI46749, MH69989), and antiretroviral and other HIV clinical trials (AI25868). Core C has provided leadership in HIV/AIDS Research communication by establishing a CFAR-wide local area network (LAN), the comprehensive UNC CFAR-DB and linked specimen repository, a monthly collaborative research meeting and a yearly AIDS symposium. Core C enhances training of medical and graduate students, post doctoral fellows and junior investigators as evidenced by support of student research projects, CFAR developmental awards and K-23 awards. Core C also helped establish productive collaborations with outside institutions and industry. Outreach efforts to international collaborators, and to HIV investigators, clinicians and HIV-infected individuals in the community are ongoing.