University of North Carolina Global HIV Prevention and Treatment Clinical Trials

描述（由申请人提供）：北卡罗来纳州大学（University of North Carolina）全球HIV临床试验部门（CTU）在高质量、创新的临床试验方面有着良好的记录。 研究，强有力的科学领导（在美国国立卫生研究院艾滋病毒/艾滋病网络内外），以及接触美国东南部和南部非洲的重要感染和高危人群。我们的CTU来自于一个横跨两大洲的多元化临床研究团队，将由三位经验丰富的首席研究员领导（Joseph Eron医学博士，Jeffrey Stringer医学博士和Mina Hosseinipour医学博士），并将支持所有5个NIH HIV临床试验网络：成人治疗战略、解决儿童和产妇中艾滋病毒和艾滋病毒相关感染的战略、艾滋病毒综合预防战略、杀微生物剂战略、预防艾滋病毒感染的疫苗策略。5个临床研究中心（CRS）将包括由大卫沃尔医学博士领导的查佩尔山CRS（成人治疗策略，综合预防，杀微生物剂和疫苗），罗利CRS领导的克里斯汀帕特森医学博士（成人治疗策略，综合预防，疫苗），格林斯伯勒CRS由科尼利厄斯货车达姆MD博士领导（成人治疗战略和综合预防）、由医学博士弗朗西斯·马丁森领导的马拉维天主教救济会（所有5个网络）和由医学博士本杰明·池领导的赞比亚天主教救济会（所有5个网络）。支持这一领导力的将是网络科学团队，由全球专家和现场合作者组成，他们将致力于执行网络科学议程。反恐组还召集了一个由高级科学家和公共卫生官员组成的多元化小组，为我们的科学和战略咨询小组服务。CTU管理层采用了高度组织化的结构，将对我们在5个地点的经验丰富的研究团队做出响应，并将提供持续的评估，以确保最佳的性能和效率。CTU将得到最先进的通信技术的支持，并汇集了优秀的实验室、药房、质量保证、数据管理和监管支持。凭借其强大的行政框架，全球艾滋病毒CTU将处于独特的地位，提供科学领导和临床试验基础设施，以推进NLAID网络的议程领域。

DESCRIPTION (provided by applicant): The University of North Carolina (UNC) Global HIV Clinical Trials Unit (CTU) has a well established track record of high-quality, innovative clinical research, strong scientific leadership (both in and outside the NIH HIV/AIDS Networks), and access to critically important infected and at-risk populations in the Southeastern US and in Southern Africa. Drawn from a diverse team of clinical innvestigators spanning two continents, our CTU will be led by three experienced principal investigators (Joseph Eron MD, Jeffrey Stringer MD and Mina Hosseinipour MD) and will support all 5 NIH HIV Clinical Trials Networks: Adult Therapeutic Strategies, Strategies to Address HIV and HIV-associated Infections in Pediatric and Maternal Populations, Integrated HIV Prevention Strategies, Microbicide Strategies, and Vaccine Strategies to Prevent HIV Infection. The 5 Clinical Research Sites (CRS) will include Chapel Hill CRS led by David Wohl MD (Adult Therapeutic Strategies, Integrated Prevention, Microbicide and Vaccine), Raleigh CRS led by Kristine Patterson MD (Adult Therapeutic Strategies, Integrated Prevention, Vaccine), Greensboro CRS led by Cornelius Van Dam MD PhD (Adult Therapeutic Strategy and Integrated Prevention), Malawi CRS led by Francis Martinson MD PhD (all 5 Networks) and Zambia CRS led by Benjamin Chi MD (all 5 Networks). Supporting this leadership will be Network Science Teams, comprising global experts and site collaborators who will work to execute the network scientific agendas. The CTU has also assembled a diverse group of senior scientists and public health officials to serve on our Scientific and Strategic Advisory Group. The CTU administration incorporates a highly organized structure that will be responsive to our experienced research teams across the 5 sites and will provide ongoing evaluation to ensure optimal performance and efficiency. The CTU will be supported by state-of-the-art communications and has assembled outstanding laboratory, pharmacy, quality assurance, data management and regulatory support. With its robust administrative framework, the UNC Global HIV CTU will be uniquely positioned to provide scientific leadership and clinical trials infrastructure to advance the field of agenda of he NlAID networks.