Clinical Core

项目总结（见说明）： FHI/RTI/CACFAR的临床核心由主任Joseph Eron博士、共同主任Prema Menezes博士和核心流行病学家Sonia Napravnik博士领导，后者还领导CACFAR艾滋病毒临床队列（UCHCC）。临床核心的目标是：1）通过提供基本服务，如受试者招募、样本获取和监管协助、研究设计和管理、研究 协调员服务和独特的资源，如访问一个详细的临床队列与链接到更大的队列和标本和组织库，再加上国家的最先进的流行病学专业知识和2）提供领导和促进高优先级的研究领域的合作，并提供指导学生和教师和教育机会，以更广泛的社区。核心包括一个专用的 拥有15名以上具备实现这些目标所需技能的工作人员。该核心中心位于FHI健康事务园区的中心，研究人员可以很容易地访问该中心，这是因为距离很近，或者因为我们的领导层和几项服务可以通过电子方式随时获得，从而促进了与FHI、RTI和国际研究人员的互动。 核心支持从分子到地理（甚至结合极端）的研究，使用从以患者为导向的定性工作到复杂的流行病学建模的方法。在过去的四年里，核心中心为100多名研究人员提供了150多个项目的服务，这些项目由美国卫生署（NIH）支持。 护理研究和质量（AHRQ）和CDC等。核心支持多个CFARiCFAR研究项目和NIH赞助的艾滋病毒网络，同时具有强大的辅导存在。核心还提供数据，领导和调查访问两个大型艾滋病毒为重点的合作队列。 临床核心是必不可少的，为核心和UCHCC提供的服务和研究机会的持续成功，研究人员和其他核心或设施的研究，FHI或RTI校园没有重复。

PROJECT SUMMARY (See instructions): The Clinical Core of the FHI/RTI/UNC CFAR is led by Dr. Joseph Eron, Director, Dr. Prema Menezes, co-Director, and Dr. Sonia Napravnik, Core Epidemiologist, who also leads the UNC CFAR HIV Clinical Cohort (UCHCC). The goals of the Clinical Core are 1) to enhance the clinical, translational and epidemiological research capacity of a diverse array CFAR investigators by providing essential services such as subject recruitment, sample access and regulatory assistance, study design and management, study coordinator services and unique resources such as access to a detailed clinical cohort with links to larger cohorts and specimen and tissue repositories coupled with state-of-the-art epidemiological expertise and 2) to provide leadership and foster collaboration in high priority research areas and provide mentorship to students and faculty and educational opportunities to the wider community. The Core includes a dedicated staff of over 15 individuals with the needed skills to accomplish these goals. The Core is housed centrally on the UNC Health Affairs campus and is easily accessible to investigators either because of close proximity or because the leadership and several of our services are readily available electronically facilitating interactions with FHl, RTI and international investigators. The Core supports research from molecular to geographic (even combining the extremes) using methods ranging from patient oriented qualitative work to complex epidemiological modeling. Over the past four years the Core served over 100 investigators on over 150 projects supported by the NIH, the Agency for Health Care Research and Quality (AHRQ) and CDC among others. The Core supports multiple CFARiCFAR research projects and NIH-sponsored HIV networks while having a strong mentoring presence. The Core also provides data, leadership and investigator access to two large HIV-focused collaborative cohorts. The Clinical Core is essential for the continued success of the UNC/FHI/RTI CFAR as the services and research opportunities provided by the Core and the UCHCC have proved invaluable to investigators and are not duplicated by other Cores or facilities on the UNC, FHl or RTI campuses.