Clinical Core

临床核心

• 批准号: 8329981
• 负责人: Joseph J Eron
• 金额: $ 34.51万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8329981
• 关键词: AIDS Malignancy Consortium; AIDS clinical trial group; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Acute; Advocate; Applications Grants; Area; Behavioral; Behavioral Research; Blood; Cancer Center; Caring; Centers for Disease Control and Prevention (U.S.); Clinic; Clinical; Clinical Research; Collaborations; Communities; Complex; County; Coupled; Criminal Justice; Data; Databases; Development; Discipline; Drug Formulations; Early treatment; Epidemiologist; Epidemiology; Evaluation; Face; Faculty; Feedback; Fostering; Genotype; Goals; Grant; Growth; HIV; HIV Infections; Health; Health Services Research; Housing; Human Resources; Individual; Industry; Institutional Review Boards; Instruction; International; Joints; K-Series Research Career Programs; Laboratories; Lead; Leadership; Link; Malignant Neoplasms; Manuscripts; Mentors; Mentorship; Methods; Molecular; North Carolina; Pathogenesis; Patients; Population; Populations at Risk; Postdoctoral Fellow; Prema; Prevention; Research; Research Design; Research Personnel; Research Priority; Research Project Grants; Research Support; Resources; Risk; Role; Sampling; Scientist; Screening procedure; Services; Specimen; Strategic Planning; Students; Surveys; Testing; Tissues; Training; Translational Research; United States National Institutes of Health; Work; base; biobank; cohort; design; epidemiological model; experience; graduate student; improved; innovation; meetings; neoplasm registry; patient oriented; population based; programs; repository; research study; skills; success; translational study; transmission process; willingness

PROJECT SUMMARY (See instructions): The Clinical Core of the FHI/RTI/UNC CFAR is led by Dr. Joseph Eron, Director, Dr. Prema Menezes, co-Director, and Dr. Sonia Napravnik, Core Epidemiologist, who also leads the UNC CFAR HIV Clinical Cohort (UCHCC). The goals of the Clinical Core are 1) to enhance the clinical, translational and epidemiological research capacity of a diverse array CFAR investigators by providing essential services such as subject recruitment, sample access and regulatory assistance, study design and management, study coordinator services and unique resources such as access to a detailed clinical cohort with links to larger cohorts and specimen and tissue repositories coupled with state-of-the-art epidemiological expertise and 2) to provide leadership and foster collaboration in high priority research areas and provide mentorship to students and faculty and educational opportunities to the wider community. The Core includes a dedicated staff of over 15 individuals with the needed skills to accomplish these goals. The Core is housed centrally on the UNC Health Affairs campus and is easily accessible to investigators either because of close proximity or because the leadership and several of our services are readily available electronically facilitating interactions with FHl, RTI and international investigators. The Core supports research from molecular to geographic (even combining the extremes) using methods ranging from patient oriented qualitative work to complex epidemiological modeling. Over the past four years the Core served over 100 investigators on over 150 projects supported by the NIH, the Agency for Health Care Research and Quality (AHRQ) and CDC among others. The Core supports multiple CFARiCFAR research projects and NIH-sponsored HIV networks while having a strong mentoring presence. The Core also provides data, leadership and investigator access to two large HIV-focused collaborative cohorts. The Clinical Core is essential for the continued success of the UNC/FHI/RTI CFAR as the services and research opportunities provided by the Core and the UCHCC have proved invaluable to investigators and are not duplicated by other Cores or facilities on the UNC, FHl or RTI campuses.

项目总结(见说明)： FHI/RTI/UNC CFAR的临床核心由主任Joseph Eron博士、联席主任Prema Meneze博士和核心流行病学家Sonia Napravnik博士领导，她也是UNC CFAR HIV临床队列(UCHCC)的负责人。临床核心的目标是1)通过提供基本服务，如受试者招募、样本获取和监管援助、研究设计和管理、研究 协调服务和独特的资源，例如访问详细的临床队列，链接到更大的队列和标本和组织库，以及最先进的流行病学专业知识；2)在高度优先的研究领域提供领导和促进合作，并为学生和教职员工提供指导，为更广泛的社区提供教育机会。核心包括一个专用的 员工超过15人，具备实现这些目标所需的技能。核心中心位于北卡罗来纳大学卫生事务园区的中央，调查人员很容易接近，因为距离很近，或者因为领导层和我们的几项服务随时可以通过电子方式提供，从而促进了与FHL、RTI和国际调查人员的互动。 核心支持从分子到地理(甚至结合极端)的研究，使用的方法范围从以患者为中心的定性工作到复杂的流行病学建模。在过去的四年里，CORE为100多名研究人员提供了超过150个由美国国立卫生研究院(NIH)支持的项目的服务 关怀、研究和质量(AHRQ)和疾病预防控制中心等。该核心支持多个CFARiCFAR研究项目和NIH赞助的艾滋病毒网络，同时拥有强大的指导存在。该核心还提供数据、领导力和调查员访问两个以艾滋病毒为重点的大型合作队列。 临床核心对于北卡罗来纳大学/FHI/RTI CFAR的持续成功至关重要，因为CORE和UCCC提供的服务和研究机会对研究人员来说是宝贵的，不会被北卡罗来纳大学、FHL或RTI校园的其他核心或设施所复制。