Clinical Retrovirology

临床逆转录病毒学

• 批准号: 7479030
• 负责人: Robert W. Coombs
• 金额: $ 18.88万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479030
• 关键词: Adhesions; Adult; Advisory Committees; Antiretroviral drug resistance; Antiviral Agents; Biostatistics Core; Blood; Clinical; Clinical Research; Clinical Trials Network; Computational Biology; Coombs' Test; Dementia; Detection; Development; Disease Progression; Disease regression; Doctor of Medicine; Doctor of Philosophy; Equipment; Evolution; Female; Genital system; Goals; Grant; HIV; HIV Infections; HIV vaccine; HIV-1; Health Services Research; Health system; Host Defense; Immunobiology; Immunology; Infection; Institution; International; Laboratories; Lung; Maintenance; Malignant Neoplasms; Measurement; Medicine; Molecular; Molecular Immunology; Molecular Virology; Monitor; Mucositis; Mycobacterium Infections; National Institute of Allergy and Infectious Disease; Pathogenesis; Peer Review Grants; Prevention; Prevention Research; Procedures; Purpose; RNA; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resource Sharing; Retrovirology; Seminal fluid; Serodiagnoses; Services; Simplexvirus; Social Behavior; Specimen; Surface; Techniques; Training Programs; Tropism; Universities; Vaccines; Variant; Viral; Washington; base; mathematical model; pediatric AIDS; professor; programs; repository; transmission process; vaccine development; virology

CORE F - University of Washington CFAR Clinical Retrovirology Laboratory Core. Director-Robert W Coombs, M.D., Ph.D., Professor, Departments of Laboratory Medicine & Medicine; Co-Director, Tuofu Zhu, M.D., Ph.D., Associate Professor, Department of Laboratory Medicine. SPECIFIC PURPOSE AND KEY SCIENTIFIC PROJECTS SUPPORTED. The specific purpose of the Clinical Retrovirology Laboratory Core is to facilitate the translational and interdisciplinary CFAR research agenda of prevention, pathogenesis and treatment of HIV infection by providing and developing HIV virology laboratory support and services for CFAR investigators. This purpose will be accomplished by providing virological markers of disease progression and regression and maintenance of a CFAR specimen repository in conjunction with the Clinical Research Core. In addition, to serological diagnosis of HIV, viral isolation, RNA and DMA quantification, and detection procedures for HIV shedding from mucosal surfaces are also available and a special expertise of Core F. A diverse virological laboratory base is important for elucidating HIV pathogenesis, vaccines and treatment strategies, which are major themes of the UW CFAR proposal. The key scientific projects in progress and currently supported by the Clinical Retrovirology Core Laboratory include: Continued laboratory support of the Adult and Pediatric AIDS Clinical Trials Networks (AI-27664; Al- 32910), HIV Vaccine Trials Network (AI-26503) and Primary Infection Program (AI-57005); HIV-1 shedding, transmission and tropism (AI-38518; R21 pending); Evolution of HIV-1 variants in semen and blood (Al- 32885, AI-35539); Virological and host determinants of HIV-1 shedding in semen (DK-49477); Effect of female genital tract infection on HIV-1 shedding and evolution (HD40540); Effect of mucosal inflammation and HSV on HIV shedding (AI-4798; CFAR/CIPRA programs); Lymphoctye adhesion and HIV activation in the lung (RO1-HL083481); Mycobacterium infection and host defense (K08-HL03577); Pathogenesis of HIV env and vaccines (AI-47086; AI-065328; HD-38653); and HIV CNS infection and dementia (R21-MH63647).

华盛顿大学CFAR临床反病毒学实验室核心。导演-罗伯特·W 库姆斯，医学博士，医学检验与医学系教授，朱拓福， 医学博士、博士、实验室医学系副教授。 支持特定用途和重点科学项目。 临床反病毒实验室核心的具体目的是促进翻译和 关于预防、发病和治疗艾滋病毒感染的跨学科CFAR研究议程 为CFAR调查人员提供和发展艾滋病毒病毒学实验室支持和服务。这一目的 将通过提供疾病进展和消退的病毒学标志物来实现 与临床研究核心一起维护CFAR标本储存库。此外， 艾滋病毒的血清学诊断、病毒分离、RNA和DNA定量以及艾滋病毒的检测程序 从粘膜表面脱落也是可用的，并且是Core F.的一项特殊专业知识。 实验室基础对于阐明艾滋病毒的发病机制、疫苗和治疗策略是重要的，这些是 UW CFAR提案的主要主题。 正在进行的和目前由临床反病毒核心实验室支持的关键科学项目 包括：继续为成人和儿童艾滋病临床试验网络提供实验室支持(AI-27664；Al- 32910)，艾滋病毒疫苗试验网络(AI-26503)和原发感染计划(AI-57005)；艾滋病毒-1脱落， 传播和嗜性(AI-38518；R21待定)；精液和血液中艾滋病毒-1变异株的进化(Al- 32885，AI-35539)；艾滋病毒-1在精液中脱落的病毒学和宿主决定因素(DK-49477)； 女性生殖道感染对HIV-1脱落和进化的影响(HD40540)；粘膜炎症的影响 和单纯疱疹病毒对艾滋病毒脱落的影响(AI-4798；CFAR/CIPRA计划)；淋巴黏附和艾滋病毒激活 肺(RO1-HL083481)；分枝杆菌感染与宿主防御(K08-HL03577)；HIV的致病机制 环境病毒和疫苗(AI-47086；AI-065328；HD-38653)；以及艾滋病毒中枢系统感染和痴呆(R21-MH63647)。