Clinical Retrovirology

核心F -华盛顿大学CFAR临床逆转录病毒学实验室核心。导演-罗伯特·W 库姆斯医学博士，哲学博士、医学检验系教授，主任，朱拓夫， 医学博士，哲学博士、检验医学系副教授。 专项和重点科研项目。 临床逆转录病毒学实验室核心的具体目的是促进翻译和 艾滋病毒感染预防、发病机制和治疗的跨学科CFAR研究议程， 为CFAR调查人员提供和发展HIV病毒学实验室支持和服务。此目的 将通过提供疾病进展和消退的病毒学标志物来实现， 与临床研究核心一起维护CFAR标本库。此外，要 HIV的血清学诊断、病毒分离、RNA和DMA定量以及HIV检测程序 粘膜表面脱落也是可用的，这是Core F的特殊专长。一个多样化的病毒学 实验室基础对于阐明艾滋病毒发病机理、疫苗和治疗策略非常重要， UW CFAR提案的主要主题。 正在进行的关键科学项目，目前由临床逆转录病毒学核心实验室支持 包括：继续为成人和儿童艾滋病临床试验网络提供实验室支持（AI-27664; AI-27664）。 32910）、HIV疫苗试验网络（AI-26503）和原发感染项目（AI-57005）; HIV-1脱落， 传播和向性（AI-38518; R21待定）;精液和血液中HIV-1变异体的演变（AI-38518; R21待定）; 32885，AI-35539）;精液中HIV-1脱落的病毒学和宿主决定因素（DK-49477）; 女性生殖道感染对HIV-1释放和演变的影响（HD 40540）;粘膜炎症的影响 和HSV对HIV脱落的影响（AI-4798; CFAR/CIPRA项目）; 肺（RO 1-HL 083481）;分枝杆菌感染和宿主防御（K 08-HL 03577）; HIV发病机制 env和疫苗（AI-47086; AI-065328; HD-38653）;以及HIV CNS感染和痴呆（R21-MH 63647）。

CORE F - University of Washington CFAR Clinical Retrovirology Laboratory Core. Director-Robert W Coombs, M.D., Ph.D., Professor, Departments of Laboratory Medicine & Medicine; Co-Director, Tuofu Zhu, M.D., Ph.D., Associate Professor, Department of Laboratory Medicine. SPECIFIC PURPOSE AND KEY SCIENTIFIC PROJECTS SUPPORTED. The specific purpose of the Clinical Retrovirology Laboratory Core is to facilitate the translational and interdisciplinary CFAR research agenda of prevention, pathogenesis and treatment of HIV infection by providing and developing HIV virology laboratory support and services for CFAR investigators. This purpose will be accomplished by providing virological markers of disease progression and regression and maintenance of a CFAR specimen repository in conjunction with the Clinical Research Core. In addition, to serological diagnosis of HIV, viral isolation, RNA and DMA quantification, and detection procedures for HIV shedding from mucosal surfaces are also available and a special expertise of Core F. A diverse virological laboratory base is important for elucidating HIV pathogenesis, vaccines and treatment strategies, which are major themes of the UW CFAR proposal. The key scientific projects in progress and currently supported by the Clinical Retrovirology Core Laboratory include: Continued laboratory support of the Adult and Pediatric AIDS Clinical Trials Networks (AI-27664; Al- 32910), HIV Vaccine Trials Network (AI-26503) and Primary Infection Program (AI-57005); HIV-1 shedding, transmission and tropism (AI-38518; R21 pending); Evolution of HIV-1 variants in semen and blood (Al- 32885, AI-35539); Virological and host determinants of HIV-1 shedding in semen (DK-49477); Effect of female genital tract infection on HIV-1 shedding and evolution (HD40540); Effect of mucosal inflammation and HSV on HIV shedding (AI-4798; CFAR/CIPRA programs); Lymphoctye adhesion and HIV activation in the lung (RO1-HL083481); Mycobacterium infection and host defense (K08-HL03577); Pathogenesis of HIV env and vaccines (AI-47086; AI-065328; HD-38653); and HIV CNS infection and dementia (R21-MH63647).