Clinical Sciences

临床科学

• 批准号: 7667255
• 负责人: Margaret A Fischl
• 金额: $ 13.77万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7667255
• 关键词: AIDS Malignancy Consortium; AIDS clinical trial group; AIDS/HIV problem; Applications Grants; Area; Behavioral; Biological; Biometry; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials Data Monitoring Committees; Cohort Studies; Complement; Data; Faculty; Fostering; Funding; Future; Goals; HIV; HIV Infections; Human Subject Research; Individual; Interdisciplinary Study; Intervention Studies; Leadership; Monitor; Needs Assessment; Outcome; Pathogenesis; Personal Satisfaction; Pilot Projects; Positioning Attribute; Prevention Research; Prevention intervention; Preventive Intervention; Publications; Research; Research Infrastructure; Research Personnel; Resources; Risk; Safety; Scientist; Services; Specimen; Therapeutic; Translational Research; United States National Institutes of Health; Universities; Work; base; experience; human subject; innovation; insight; multidisciplinary; performance site; programs; prospective; repository

The Clinical Support Core (CSC) will support and facilitate collaborative research among basic, clinical, and behavioral scientists that involves human subjects and biological specimens and provide an infrastructure that will enhance and facilitate multidisciplinary pathogenesis and translational HIV/AIDS research. The longterm overarching goal of the CSC is to support and enhance multidisciplinary research that will advance therapeutic and prevention interventions for individuals with HIV infection or at risk for HIV infection. Based on identified gaps in support to University of Miami HIV/AIDS investigators, the CSC will focus on three specific aims to facilitate and complement University wide efforts in pathogenesis and translational HIV/AIDS research. These aims and the services provided will also foster multidisciplinary collaborations among the HIV/AIDS investigators. The specific aims for the CSC are: 1. to establish a Biostatistics Subcore dedicated to HIV/AIDS research; 2. to establish a clinical repository and prospective longitudinal specimen bank for future pathogenesis and multidisciplinary research; and 3. To establish a Safety Monitoring Committee and a Data Safety Monitoring Board to meet the emerging needs of human subjects' research. The accomplishment of these aims will provide meet unmet needs and provide added value to our HIV/AIDS research programs through several tangible outcomes. These outcomes are anticipated to include new studies and resulting publications, preliminary data for new grant applications, new insights and directions in pathogenesis/translational research, and fostering new multidisciplinary collaborative studies. In addition, the establishment of clinical repository and specimen bank will provide significant opportunities and result in added value, including new insights into pathogenesis, promoting innovative pilot studies, providing preliminary data for new grant applications, fostering new multidisciplinary collaborations, and capitalizing upon existing therapeutic and preventive intervention studies, and cohort studies. The contributions and progress made by clinical therapeutic and prevention research have been unparalleled in the advancement of HIV clinical science. These advances have been seeded by the continuing ability to do pathogenesis and translational research. The CSC will work collaboratively with the Scientific Programs and the D-CFAR Core leadership in providing an infrastructure that will support multidisciplinary research and foster new opportunities in the areas of pathogenesis and translational research as it relates to human subjects. PERFORMANCE SITE(

临床支持核心（CSC）将支持和促进基础，临床和 行为科学家，涉及人类主体和生物标本，并提供一个基础设施， 这将加强和促进多学科发病机制和转化艾滋病毒/艾滋病研究。的长期 CSC的总体目标是支持和加强多学科研究， 针对艾滋病毒感染者或有艾滋病毒感染风险的个人的治疗和预防干预措施。 根据在支持迈阿密大学艾滋病毒/艾滋病调查人员方面发现的差距，CSC将重点关注 三个具体目标，以促进和补充大学广泛的努力，在发病机制和翻译 艾滋病毒/艾滋病研究。这些目标和提供的服务也将促进多学科合作 艾滋病调查员中的一员CSC的具体目标是：1。设立生物统计分中心 致力于艾滋病研究; 2.建立临床标本库和前瞻性纵向标本库 未来发病机制和多学科研究库; 3.建立安全监测 委员会和数据安全监测委员会，以满足人类受试者研究的新需求。 这些目标的实现将满足尚未满足的需求，并为我们的艾滋病毒/艾滋病工作提供附加值 通过几个具体的研究成果。这些成果预计将包括新的 研究和由此产生的出版物，新的赠款申请的初步数据，新的见解和方向， 发病机制/转化研究，并促进新的多学科合作研究。此外该 建立临床储存库和标本库将提供重要机会， 增加价值，包括对发病机制的新见解，促进创新的试点研究， 新的赠款申请的初步数据，促进新的多学科合作， 基于现有的治疗和预防干预研究以及队列研究。 临床治疗和预防研究的贡献和进展是无与伦比的 艾滋病临床科学的进步。这些进步的基础是， 做发病机理和转化研究。CSC将与科学计划合作 以及D-CFAR核心领导层，提供支持多学科研究的基础设施 并在发病机制和转化研究领域创造新的机会，因为它涉及人类 科目 表演场地（