Clinical Sciences

临床科学

• 批准号: 7667255
• 负责人: Margaret A Fischl
• 金额: $ 13.77万
• 依托单位: UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7667255
• 关键词: AIDS Malignancy Consortium; AIDS clinical trial group; AIDS/HIV problem; Applications Grants; Area; Behavioral; Biological; Biometry; Clinical; Clinical Investigator; Clinical Research; Clinical Sciences; Clinical Trials Data Monitoring Committees; Cohort Studies; Complement; Data; Faculty; Fostering; Funding; Future; Goals; HIV; HIV Infections; Human Subject Research; Individual; Interdisciplinary Study; Intervention Studies; Leadership; Monitor; Needs Assessment; Outcome; Pathogenesis; Personal Satisfaction; Pilot Projects; Positioning Attribute; Prevention Research; Prevention intervention; Preventive Intervention; Publications; Research; Research Infrastructure; Research Personnel; Resources; Risk; Safety; Scientist; Services; Specimen; Therapeutic; Translational Research; United States National Institutes of Health; Universities; Work; base; experience; human subject; innovation; insight; multidisciplinary; performance site; programs; prospective; repository

The Clinical Support Core (CSC) will support and facilitate collaborative research among basic, clinical, and behavioral scientists that involves human subjects and biological specimens and provide an infrastructure that will enhance and facilitate multidisciplinary pathogenesis and translational HIV/AIDS research. The longterm overarching goal of the CSC is to support and enhance multidisciplinary research that will advance therapeutic and prevention interventions for individuals with HIV infection or at risk for HIV infection. Based on identified gaps in support to University of Miami HIV/AIDS investigators, the CSC will focus on three specific aims to facilitate and complement University wide efforts in pathogenesis and translational HIV/AIDS research. These aims and the services provided will also foster multidisciplinary collaborations among the HIV/AIDS investigators. The specific aims for the CSC are: 1. to establish a Biostatistics Subcore dedicated to HIV/AIDS research; 2. to establish a clinical repository and prospective longitudinal specimen bank for future pathogenesis and multidisciplinary research; and 3. To establish a Safety Monitoring Committee and a Data Safety Monitoring Board to meet the emerging needs of human subjects' research. The accomplishment of these aims will provide meet unmet needs and provide added value to our HIV/AIDS research programs through several tangible outcomes. These outcomes are anticipated to include new studies and resulting publications, preliminary data for new grant applications, new insights and directions in pathogenesis/translational research, and fostering new multidisciplinary collaborative studies. In addition, the establishment of clinical repository and specimen bank will provide significant opportunities and result in added value, including new insights into pathogenesis, promoting innovative pilot studies, providing preliminary data for new grant applications, fostering new multidisciplinary collaborations, and capitalizing upon existing therapeutic and preventive intervention studies, and cohort studies. The contributions and progress made by clinical therapeutic and prevention research have been unparalleled in the advancement of HIV clinical science. These advances have been seeded by the continuing ability to do pathogenesis and translational research. The CSC will work collaboratively with the Scientific Programs and the D-CFAR Core leadership in providing an infrastructure that will support multidisciplinary research and foster new opportunities in the areas of pathogenesis and translational research as it relates to human subjects. PERFORMANCE SITE(

临床支持核心（CSC）将支持和促进基础、临床和临床之间的合作研究 涉及人类受试者和生物样本并提供基础设施的行为科学家 这将加强和促进多学科发病机制和转化艾滋病毒/艾滋病研究。长期来看 CSC 的总体目标是支持和加强多学科研究，以推进 针对 HIV 感染者或有 HIV 感染风险的个体的治疗和预防干预措施。 根据已发现的对迈阿密大学艾滋病毒/艾滋病调查人员支持方面的差距，CSC 将重点关注 促进和补充大学在发病机制和转化方面的努力的三个具体目标 艾滋病毒/艾滋病研究。这些目标和提供的服务也将促进多学科合作 艾滋病毒/艾滋病调查人员中。 CSC 的具体目标是： 1. 建立生物统计子核心 致力于艾滋病毒/艾滋病研究； 2. 建立临床资料库和前瞻性纵向标本 未来发病机制和多学科研究的银行； 3. 建立安全监控 委员会和数据安全监测委员会，以满足人类受试者研究的新需求。 这些目标的实现将满足未满足的需求，并为我们的艾滋病毒/艾滋病提供附加值 通过多项切实成果的研究计划。预计这些成果将包括新的 研究和由此产生的出版物、新拨款申请的初步数据、新的见解和方向 发病机制/转化研究，并促进新的多学科合作研究。此外， 建立临床资源库和标本库将提供重大机遇并带来 附加值，包括对发病机制的新见解、促进创新试点研究、提供 新拨款申请的初步数据，促进新的多学科合作，并利用 根据现有的治疗和预防干预研究以及队列研究。 临床治疗和预防研究所做出的贡献和进展是无与伦比的 推动艾滋病毒临床科学的发展。这些进步是由持续的能力播下的种子 进行发病机制和转化研究。 CSC 将与科学计划合作 以及 D-CFAR 核心在提供支持多学科研究的基础设施方面的领导地位 并在与人类相关的发病机制和转化研究领域培育新的机遇 科目。 演出现场(