Endochondral Potential of Trunk Neural Crest Cells
躯干神经嵴细胞的软骨内电位
基本信息
- 批准号:7609122
- 负责人:
- 金额:$ 4.86万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-04-01 至 2009-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Neural crest cells (NCCs) are ectodermally derived stem cells that differentiate into a wealth of
derivatives. NCCs from the cranial region of higher vertebrates generate cartilage and bone.
Trunk NCCs don't generate bone or cartilage under normal development, but they can be
induced to do so in vitro, or when experimentally grafted in specific bone forming territories of
the cranium. We have recently shown that the induction of cranial NCCs occurs during
gastrulation, much earlier than previously thought (Basch et al. 2006). Additionally we uncover a
neural crest induction mechanism independent of mesodermal and neural tissues. These results
depart from current dogmas of neural crest induction and provide a new timeframe for NCCs
development.
The aim of this proposal is to identify the molecular principles governing the chondrogenic
differentiation potential of. this critical stem cell for vertebrate development. We propose to
challenge the bone and cartilage potential of trunk NCCs through grafting strategies to prove the
role of early signals of induction. Then we will test the effects of caudalizing signals (FGF and
Wnt) in the chondrogenic differentiation potential of both trunk and cranial NCC.
神经嵴细胞(NCCs)是外胚层来源的干细胞,分化成丰富的神经嵴细胞
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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MARTIN I. GARCIA-CASTRO其他文献
MARTIN I. GARCIA-CASTRO的其他文献
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{{ truncateString('MARTIN I. GARCIA-CASTRO', 18)}}的其他基金
Bridges to the Baccalaureate Research Training Program at University of California, Riverside
通往加州大学河滨分校学士学位研究培训计划的桥梁
- 批准号:
10674969 - 财政年份:2022
- 资助金额:
$ 4.86万 - 项目类别:
Molecular Interactions During Neural Crest Formation
神经嵴形成过程中的分子相互作用
- 批准号:
9323831 - 财政年份:2015
- 资助金额:
$ 4.86万 - 项目类别:
Molecular Interactions During Neural Crest Formation
神经嵴形成过程中的分子相互作用
- 批准号:
9533912 - 财政年份:2015
- 资助金额:
$ 4.86万 - 项目类别:
Molecular Interactions During Neural Crest Formation
神经嵴形成过程中的分子相互作用
- 批准号:
9107454 - 财政年份:2015
- 资助金额:
$ 4.86万 - 项目类别:
Molecular Interactions During Neural Crest Formation
神经嵴形成过程中的分子相互作用
- 批准号:
8862451 - 财政年份:2015
- 资助金额:
$ 4.86万 - 项目类别:
Molecular Interactions During Neural Crest Formation
神经嵴形成过程中的分子相互作用
- 批准号:
9536336 - 财政年份:2015
- 资助金额:
$ 4.86万 - 项目类别:
Molecular Interactions During Neural Crest Formation
神经嵴形成过程中的分子相互作用
- 批准号:
9118977 - 财政年份:2015
- 资助金额:
$ 4.86万 - 项目类别:
Molecular Interactions During Neural Crest Formation
神经嵴形成过程中的分子相互作用
- 批准号:
7934225 - 财政年份:2010
- 资助金额:
$ 4.86万 - 项目类别:
Molecular Interactions during Neural Crest Formation
神经嵴形成过程中的分子相互作用
- 批准号:
10458050 - 财政年份:2007
- 资助金额:
$ 4.86万 - 项目类别:
Endochondral Potential of Trunk Neural Crest Cells
躯干神经嵴细胞的软骨内电位
- 批准号:
7509048 - 财政年份:2007
- 资助金额:
$ 4.86万 - 项目类别:
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