MDIBL STEER: Pathways of Chemical Action in Human Disease

描述（由申请人提供） 山漠岛生物实验室 (MDIBL) 和 MDIBL 的 NIEHS 膜毒性研究中心 (CMTS) 提议为六名缅因州高中生提供短期研究教育体验 (STEER)。 MDIBL STEER 计划的总体目标是将选定的学生与 NIEHS 中心研究人员相匹配，以获得环境健康科学方面的实践研究经验。科学主题是“人类疾病中的化学作用途径”，这与该中心的使命相一致，即在细胞和分子水平上阐明环境毒物的毒性机制和排泄途径。除了研究经验之外，每个学生还将收集一份奖学金档案袋，包括他们的实验室笔记本和其他组件来记录他们的奖学金。学生将参加外部活动以丰富实验室经验，包括期刊俱乐部会议、科学研讨会和演讲。缅因大学研究与评估中心将进行项目评估和分析，以及短期学生跟踪。 MDIBL 将跟踪 STEER 参与者完成 STEER 计划后的教育和职业道路。 STEER 管理人员将与当地高中教师合作，由他们提名申请该计划的学生，并帮助 MDIBL 识别因民族、种族或来自经济或教育弱势背景的个人而在科学领域代表性不足的学生。 MDIBL STEER 计划的具体目标是： 1. 在国家认可的基础科学家和医学科学家的指导下，为缅因州高中生提供环境健康科学领域的多学科研究经验，并将其应用于人类健康；2. 为缅因州高中生继续攻读环境健康科学的本科和研究生学位课程提供渠道。

DESCRIPTION (provided by applicant) The Mount Desert Island Biological Laboratory (MDIBL) and the NIEHS Center for Membrane Toxicity Studies (CMTS) at MDIBL propose a Short-Term Educational Experience for Research (STEER) for six Maine high school students. The overall goal of the MDIBL STEER program is to match selected students with NIEHS Center investigators for a hands-on research experience in the environmental health sciences. The scientific theme is "Pathways of Chemical Action in Human Disease", which parallels the Center's mission to elucidate the mechanisms of toxicity and pathways of excretion of environmental toxicants at the cellular and molecular level. In addition to the research experience, each student will assemble a fellowship portfolio, including their laboratory notebook, and other components to document their fellowship. Students will participate in external activities to enrich the laboratory experience including journal club meetings, scientific seminars, and presentations. The Center for Research and Evaluation at the University of Maine will conduct program evaluation and analysis, as well as short-term student follow-up. MDIBL will track the educational and career paths of STEER participants beyond their completion of the STEER program. STEER administrators will work with local high school teachers who will nominate students to apply to the program, and who will help MDIBL identify students underrepresented in science by virtue of their ethnicity, race, or individuals from economically or educationally disadvantaged backgrounds. The specific aims of the MDIBL STEER program are: 1. To provide Maine high school students with multidisciplinary research experiences in the environmental health sciences with applications to human health, mentored by nationally recognized basic scientists and physician scientists and 2. To serve as a pipeline for Maine high school students to continue in undergraduate and graduate degree programs in the environmental health sciences.