MDIBL STEER: Pathways of Chemical Action in Human Disease

描述(由申请人提供) 沙漠山生物实验室(MDIBL)和NIEHS膜毒性研究中心(CMTS)建议为六名缅因州高中生提供短期研究教育体验(STER)。MDIBL STEER计划的总体目标是将选定的学生与NIEHS中心的研究人员相匹配，以获得环境健康科学方面的实践研究经验。科学主题是“人类疾病中的化学作用途径”，这与该中心在细胞和分子水平上阐明环境毒物的毒性机制和排泄途径的使命是一致的。除了研究经验，每个学生还将收集一份奖学金文件夹，包括他们的实验室笔记本和其他组件，以记录他们的奖学金。学生将参加外部活动，以丰富实验室经验，包括期刊俱乐部会议、科学研讨会和演讲。缅因州大学研究和评估中心将进行项目评估和分析，以及短期学生跟踪调查。MDIBL将跟踪STEER参与者在完成STEER计划后的教育和职业道路。Steer管理人员将与当地高中教师合作，后者将提名学生申请该项目，并将帮助MDIBL识别因其种族、种族或来自经济或教育不利背景的个人而在科学领域代表性不足的学生。MDIBL STEER计划的具体目标是：1.在国家公认的基础科学家和内科科学家的指导下，为缅因州高中生提供环境健康科学方面的多学科研究经验，并应用于人类健康；2.作为缅因州高中生继续攻读环境健康科学本科和研究生学位课程的渠道。

DESCRIPTION (provided by applicant) The Mount Desert Island Biological Laboratory (MDIBL) and the NIEHS Center for Membrane Toxicity Studies (CMTS) at MDIBL propose a Short-Term Educational Experience for Research (STEER) for six Maine high school students. The overall goal of the MDIBL STEER program is to match selected students with NIEHS Center investigators for a hands-on research experience in the environmental health sciences. The scientific theme is "Pathways of Chemical Action in Human Disease", which parallels the Center's mission to elucidate the mechanisms of toxicity and pathways of excretion of environmental toxicants at the cellular and molecular level. In addition to the research experience, each student will assemble a fellowship portfolio, including their laboratory notebook, and other components to document their fellowship. Students will participate in external activities to enrich the laboratory experience including journal club meetings, scientific seminars, and presentations. The Center for Research and Evaluation at the University of Maine will conduct program evaluation and analysis, as well as short-term student follow-up. MDIBL will track the educational and career paths of STEER participants beyond their completion of the STEER program. STEER administrators will work with local high school teachers who will nominate students to apply to the program, and who will help MDIBL identify students underrepresented in science by virtue of their ethnicity, race, or individuals from economically or educationally disadvantaged backgrounds. The specific aims of the MDIBL STEER program are: 1. To provide Maine high school students with multidisciplinary research experiences in the environmental health sciences with applications to human health, mentored by nationally recognized basic scientists and physician scientists and 2. To serve as a pipeline for Maine high school students to continue in undergraduate and graduate degree programs in the environmental health sciences.