ANIMAL RESOURCES CORE

动物资源核心

• 批准号: 7186803
• 负责人: MOLLIE ANNE BLOOMSMITH
• 金额: $ 54.02万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7186803
• 关键词: Age; Anesthesia procedures; Animals; Autopsy; Blood; Caring; Class; Clinical; Conflict (Psychology); Data Analyses; Doctor of Philosophy; Documentation; Ensure; Exclusion; Grant; Health; Health Status; Individual; Macaca mulatta; Monitor; Monkeys; Nature; Pan Genus; Pan troglodytes; Population; Positive Reinforcements; Problem behavior; Procedures; Recording of previous events; Records; Recovery; Research; Research Personnel; Research Project Grants; Resources; Schedule; Selection Criteria; Socialization; Surveys; Techniques; Training; Training Programs; Well in self; animal resource; base; member; nonhuman primate; programs

The Animal Resources Core, to be led by Mollie Bloomsmith, PhD, will ensure that all animals selected for the Program Project meet the entrance criteria developed jointly by the Program Project investigators. In addition, members of the Core will monitor the status of the subjects throughout the grant period to ensure their continued appropriateness. The nonhuman primate subjects will be obtained from the YNPRC colony which maintains a valuable resource of rhesus macaques and chimpanzees of appropriate age classes for this research. Veterinary care will be supplied to promote health of the subjects and to manage the experimental procedures included in the Program Project. Environmental enrichment, socialization, and animal training programs will be applied to promote the psychological well-being of the nonhuman primate subjects in these studies, and to facilitate the conduct of high quality research with this important population. The specific aims of the Animal Resources Core are to: (1) Review the health and experimental records of all animal subjects prior to assignment, to determine if they meet the selection criteria described below, (2) review the health status of all monkeys and chimpanzees in the Program Project on a regular basis, perform routine clinical examinations including blood analyses and ophthalmologic examinations, and insure that the continued use of individual animals by the Program Project is appropriate, (3) coordinate the assignment of monkeys and chimpanzees to specific research projects, so as to avoid scheduling conflicts between users in the Program Project, (4) promote the psychological well-being of all monkeys and chimpanzees in the Program Project by providing'environmental enrichment to minimize behavioral problems, coordinate the socialization of subjects with their research use, and train animals to cooperate with experimental procedures using positive reinforcement techniques, (5) review results of postmortem autopsies and pathological surveys to determine whether undiagnosed health problems were present, the nature of which would warrant exclusion from the data analyses, (6) ensure prompt, thorough, and efficient access to all veterinary and animal-history records required by members of the Program Project, and, (7) ensure adequate oversight of anesthesia and documentation of recovery for designated experimental procedures.

由Mollie Bloomsmith博士领导的动物资源核心将确保所有选择用于 该计划项目符合由计划项目调查人员共同制定的入学标准。在 此外，核心成员将在整个资助期间监测受试者的状况，以确保 持续的适当性。非人灵长类动物受试者将从YNPRC群体获得 它保持着一个宝贵的资源，恒河猴和黑猩猩的适当年龄组， 这项研究。将提供兽医护理，以促进受试者的健康并管理 实验程序包括在计划项目中。环境丰富化、社会化和 动物训练计划将用于促进非人灵长类动物的心理健康 这些研究中的受试者，并促进对这一重要人群进行高质量的研究。 动物资源核心的具体目标是：（1）审查动物的健康和实验记录。 分配前的所有动物受试者，以确定它们是否符合下述选择标准，（2） 定期审查项目中所有猴子和黑猩猩的健康状况， 常规临床检查，包括血液分析和眼科检查，并确保 项目继续使用个别动物是适当的，（3）协调分配 猴子和黑猩猩的特定研究项目，以避免用户之间的调度冲突 在该计划项目中，（4）促进非洲所有猴子和黑猩猩的心理健康， 通过提供“环境丰富，以尽量减少行为问题，协调 使受试者与他们的研究用途社会化，并训练动物与实验合作， 使用积极强化技术的程序，（5）审查尸检结果， 病理调查，以确定是否存在未诊断的健康问题，其性质 将保证从数据分析中排除，（6）确保及时，彻底和有效地访问所有 （7）项目成员要求的兽医和动物历史记录，以及（7）确保 充分监督指定实验程序的麻醉和恢复记录。