TAILORING ENRICHMENT TO REARING AND RESEARCH

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本项目包括与非人类灵长类动物种群管理相关的几项研究，这些研究与综合环境富集计划的发展有关。为了在改进研究设施中灵长类动物的护理方面继续取得进展，有必要更好地确定如何使富集技术适合于生物医学研究中使用的灵长类动物的管理。生物医学研究可能需要限制可用于研究动物的富集技术的类型，同时可能改变动物的心理需求。拟议的项目将为恒河猴（Macaca mulatta）的健康和管理提供直接利益。重点将放在管理的三个方面，这些方面可能会因饲养和研究用途而有很大差异：(1)社会分组，包括将关在一起的猴子与关在一起的猴子进行比较，这样它们就可以通过渗透屏障进行互动；(2)人类互动，作为单独关在一起的猴子的一种充实形式；(3)对持续存在心理困扰的个体的治疗，包括社会化、人类互动和药物干预。该项目是灵长类动物行为学家和兽医之间的合作成果。行为和生理依赖的措施被用作幸福的指标，包括正常和异常行为、健康评估、临床治疗记录和皮质醇浓度。采用非参数统计和参数统计对数据进行分析。拟议的研究利用了一个独特的机会来记录改变环境改善的影响，与改进的行为管理保持一致，并测量了各种结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project includes several studies relevant to the management of nonhuman primate colonies in relation to development of a comprehensive environmental enrichment program. In order to continue progress in refining the care of primates in research facilities, it is necessary to better determine how enrichment techniques should be tailored to the management of primates used in biomedical research. Biomedical studies may require restrictions on the type of enrichment techniques that can be implemented for study animals, and may at the same time alter the psychological needs of the animals. The proposed project will provide direct benefit to the well-being and management of rhesus macaques (Macaca mulatta). Focus will be placed on three aspects of management that may vary considerably with rearing and research use: (1) social grouping including a comparison of monkeys housed together with those housed such that they interact through a permeated barrier, (2) human interaction as a form of enrichment for singly housed monkeys, and (3) the treatment of individuals in persistent psychological distress, including socialization, human interaction, and a medication as interventions. The project is a collaborative effort between primate behaviorists and veterinarians. Behavioral and physiological dependent measures are employed as indicators of well-being, including normal and abnormal behavior, health assessments, clinical treatment records, and cortisol concentrations. Nonparametric and parametric statistics are employed to analyze data. The proposed study takes advantage of a unique opportunity to document the effects of altering environmental enhancement in keeping with improved behavioral management, and measuring a variety of outcomes.