TAILORING ENRICHMENT TO REARING AND RESEARCH

定制丰富的饲养和研究

• 批准号: 7562524
• 负责人: MOLLIE ANNE BLOOMSMITH
• 金额: $ 4.74万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7562524
• 关键词: Animals; Behavior; Behavioral; Biomedical Research; Caring; Clinical Treatment; Computer Retrieval of Information on Scientific Projects Database; Development; Funding; Grant; Health behavior; Housing; Human; Hydrocortisone; Individual; Institution; Intervention; Macaca mulatta; Measures; Monkeys; Outcome; Personal Satisfaction; Physiological; Positive Reinforcements; Primates; Records; Research; Research Personnel; Resources; Socialization; Source; Techniques; Time; Training; United States National Institutes of Health; improved; nonhuman primate; programs; psychologic; psychological distress; research facility; social group

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project includes several studies relevant to the management of nonhuman primate colonies in relation to development of a comprehensive environmental enrichment program. To continue progress in refining the care of primates in research facilities, it is necessary to better determine how enrichment techniques should be tailored to the management of primates used in biomedical research. Biomedical studies may require restrictions on the type of enrichment techniques that can be implemented for study animals, and may at the same time alter the psychological needs of the animals. This project provides direct benefit to the well-being and management of rhesus macaques (Macaca mulatta). Focus has been placed on three aspects of management that may vary considerably with rearing and research use: (1) social grouping including a comparison of monkeys housed together with those housed such that they interact through a permeated barrier, (2) human interaction as a form of enrichment for singly housed monkeys, and (3) the treatment of individuals in persistent psychological distress, including socialization and human interaction as interventions. Behavioral and physiological dependent measures are employed as indicators of well-being, including normal and abnormal behavior, health assessments, clinical treatment records, and cortisol concentrations. Results indicate that positive reinforcement training is not an effective intervention for various types of abnormal behaviors sometimes expressed in rhesus monkeys. The study takes advantage of a unique opportunity to document the effects of altering environmental enhancement in keeping with improved behavioral management, and measuring a variety of outcomes.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目包括几项与非人类灵长类动物群体管理相关的研究，以及制定全面的环境丰富计划。 为了继续改进研究设施中灵长类动物的护理，有必要更好地确定如何针对生物医学研究中使用的灵长类动物的管理定制富集技术。 生物医学研究可能需要限制可用于研究动物的富集技术类型，同时可能会改变动物的心理需求。 该项目为恒河猴（Macaca mulatta）的福祉和管理提供直接效益。 重点放在管理的三个方面，这些方面可能因饲养和研究用途而有很大差异：（1）社会分组，包括对共同饲养的猴子与通过渗透性屏障进行互动的猴子进行比较，（2）人类互动作为单独饲养的猴子的丰富形式，以及（3）对持续心理困扰的个体的治疗，包括作为干预措施的社会化和人类互动。 行为和生理依赖性测量被用作健康指标，包括正常和异常行为、健康评估、临床治疗记录和皮质醇浓度。 结果表明，正强化训练并不是对恒河猴有时表现出的各种异常行为的有效干预措施。该研究利用了一个独特的机会来记录改变环境改善以适应改进的行为管理的效果，并测量各种结果。