CORE--ANALYTIC

核心--分析

• 批准号: 7447872
• 负责人: NOURI NEAMATI
• 金额: $ 20.18万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7447872
• 关键词: Alzheimer' s disease model; Animals; Bioinformatics; Blood; Brain; Brain region; Cataloging; Catalogs; Cluster Analysis; Custom; Discrimination; Electrons; Ensure; Future; Gases; Gene Expression; Genes; Hippocampus (Brain); Hormone Antagonists; Hormones; Individual; Liquid substance; Mass Spectrum Analysis; Menopause; Modeling; Mus; Numbers; Pathway interactions; Pattern; Pattern Recognition; Perimenopause; Pharmacologic Substance; Plasma; Polymerase Chain Reaction; Process; Progesterone; Proteins; Purpose; RNA Processing; Radioimmunoassay; Rattus; Research; Research Personnel; Reverse Transcriptase Polymerase Chain Reaction; Sampling; Science; Serum; Services; Solutions; Specimen; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time; Tissue Banking; Tissue Sample; Tissues; Translational Research; Urine; Uterus; brain tissue; computational chemistry; detector; hormone metabolism; inhibitor/antagonist; ionization; member; professor; programs; research study

Core C: Analytic The Analytical Core, under the direction of Dr. Nouri Neamati, Assistant Professor of Pharmaceutical Sciences, will process, bank, and analyze all tissues and appropriate samples for research purposes for use in this Program Project. The tissues as well as fluid, specimens including blood, serum, and urine will be collected where needed for individual investigators with hypothesis driven translational research. The Analytical Core will provide the following services where appropriate: 1) Macroarray analysis of 100 highly relevant customized genes using SuperArray platform. 2) Real-Time PCR for selected genes. 3) Mass Spectrometry including MALDI and MS/MS analysis for selected samples. 4) Progesterone and metabolite analysis by Gas Chromatograph with Mass Selective Detector utilizing Electron Impact ionization, and 5) Quantitative analysis of progesterone and metabolites by radioimmunoassays.

核心C：分析