NMR Monitoring of Temperature and Its Biological Effects

温度及其生物效应的核磁共振监测

基本信息

批准号：
7459620
负责人：
NAVIN BANSAL
金额：
$ 26.98万
依托单位：
INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-10 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7459620
关键词：
Acids Acute Aftercare Animal Experiments Biological Biological Assay Biology Blood Vessels Cancer Detection Chemicals Complex Data Data Collection Dependence Detection Development Diagnosis Diffusion Diffusion Magnetic Resonance Imaging Dose Exercise Experimental Neoplasms Feedback Fever Funding Gadolinium Glioma Goals Grant Heating Histology Human Image Imaging Techniques Implant Induced Hyperthermia Ions Lanthanoid Series Elements Localized Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Magnetism Malignant Neoplasms Measurement Measures Medical Metabolic Metabolism Methods Molecular Monitor Motion Mus Muscle Other Therapy Outcome Patients Perfusion Phase Physiological Physiology Predisposition Protons Radiation Rate Rattus Reagent Recovery Relaxation Research Personnel Resolution Signal Transduction Sodium Spectrum Analysis Surrogate Markers Techniques Temperature Testing Thermometers Thermometry Thulium Time Tissues Tumor Volume Variant Water base cancer therapy cold temperature design extracellular fibrosarcoma hyperthermia treatment in vivo innovation macromolecule programs quantum radiofrequency response therapy outcome tumor

项目摘要

DESCRIPTION (provided by applicant): Noninvasive temperature monitoring has many direct uses in diagnosis and therapy. These include aiding in the use of hyperthermia (HT) for treatment of cancer, detection and localization of tumors, diagnosing metabolic abnormalities, and studying muscle exercise and recovery. Noninvasive monitoring of temperature is particularly useful for HT treatment of malignant tumors, where the amount of heat applied depends on the actual temperature in the region and its surroundings. Using the funding from a R21 grant (R21 CA94040) we have developed a noninvasive MR thermometer based on the temperature dependence of hyperfine shifted 1H signal of the paramagnetic lanthanide complex, TmDOTMA". 1H chemical shifts of TmDOTMA" are -60 times more sensitive to temperature than the water signal and are insensitive to changes in tissue microenvironment such as pH and concentration of other ions and presence of macromolecules. Our preliminary data show that the developed thermometer, based on the proton chemical shift of TmDOTMA", provides sensitive and accurate methods for monitoring temperature. The overall goal of this R33 proposal is to combine the developed MR thermometry method with other multinuclear MR measurements to investigate the metabolic and physiologic effects HT in experimental tumors during the treatment. The central hypothesis of the proposal is that biological response of tumors, as measured by noninvasive MR spectroscopy and imaging (MRS/MRI) at the time of HT treatment, provides more accurate and reliable information about therapy outcome than HT temperature alone because different tumors or tumor regions have different vulnerability to temperature. To test this hypothesis, robust MR methods will be developed to deliver controlled radiofrequency (RF) HT in the magnet and simultaneously monitor/image the metabolic and physiological effects of HT by in vivo 31P, 23Na, and 1H MRS/MRI. The proposed MR techniques will provide innovative methods to monitor temperature and metabolic/physiologic response to HT treatment during and after the therapy. Application of the proposed techniques to experimental tumors will enhance our understanding of HT biology, which may prove valuable in designing methods to sensitize tumors to HT and other therapies. The animal experiments will be a step toward the application of the proposed techniques to human patients for MRI-guided HT treatment.

描述（由申请人提供）：非侵入性温度监测在诊断和治疗中有许多直接用途。这些包括有助于使用高温（HT）治疗癌症的治疗，肿瘤的检测和定位，诊断代谢异常以及研究肌肉运动和康复。对温度的无创监测对于HT治疗恶性肿瘤特别有用，其中施加的热量取决于该地区及其周围环境的实际温度。使用R21赠款（R21 CA94040）的资金，我们基于高精细的温度依赖性而开发了无创的MR温度计，对磁磁性腺苷酸复合物的温度依赖性转移了1H信号，TMDOTMA，TMDOTMA”。1HTMDOTMA的化学移位对TMDOTMA的化学移位对TMDOTMA的化学移位对水信号和温度的敏感性更高，而不是水信号和较高的水位敏感性，而不是水中敏感的敏感性，而不是水中的敏感性，则是敏感的，是敏感的，敏感的是敏感的，是敏感的，是敏感的，敏感的是敏感的，是敏感的，是敏感的，是敏感的，是敏感的，敏感的是敏感的。离子和大分子的存在。我们的初步数据表明，根据TMDOTMA的质子化学移位，开发的温度计为监测温度提供了敏感而准确的方法。该R33提案的总体目标是将开发的MR温度测量方法与其他多核MR测量结果结合在一起，以研究中心的生物学效应。 HT治疗时的非侵入性MR光谱和成像（MRS/MRI）与单独的HT温度相比，提供了有关治疗结果的更准确和可靠的信息，因为不同的肿瘤或肿瘤区域具有不同的温度脆弱性，可以开发出可靠的MR。通过体内31p，23NA和1H MRS/MRI，提出的MR技术将提供对治疗过程中HT治疗的温度和代谢/生理响应的创新方法。提出的技术在人类患者中的应用进行MRI引导的HT治疗。