Non-invasive MR thermometry using a paramagnetic complex

使用顺磁复合体进行非侵入式 MR 测温

• 批准号: 6420017
• 负责人: NAVIN BANSAL
• 金额: $ 14.84万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420017
• 关键词: bioimaging /biomedical imaging; contrast media; image enhancement; laboratory mouse; magnetic resonance imaging; neoplasm /cancer thermotherapy; rare earth element; technology /technique development; thermometry

DESCRIPTION (Provided by Applicant): Noninvasive thermometry is pivotal to the future advances of regional hyperthermia as a treatment modality. Current magnetic resonance (MR) thermometry methods suffer from poor resolution due to relatively weak dependence of chemical shift of the 1H water signal on temperature. The main objective of this research is to develop noninvasive MR thermometry methods for reliable and accurate monitoring and imaging of temperature in tumors using a paramagnetic lanthanide complex. Our preliminary data show that 1H chemical shifts of a prototype lanthanide complex, thulium- 1,4,7,10-tetraazacyclododecane-1 ,4,7,10- tetraacetate (TmDOTA), are about two orders of magnitudes more sensitive to temperature than the water and thus, provide excellent accuracy and resolution. In addition, TmDOTA proton shifts are insensitive to the paramagnetic complex concentration, ph, [Ca2+] or presence of plasma macromolecules and ions. This will greatly simplify the procedures for using the lanthanide complex for MR thermometry because hyperthermia is known to produce changes in tissue pH and other parameters. The main goals of this project are: 1) to investigate the use of methyl substituted analogs of TmDOTK, thulium 1,4,7,1 0-Tetraazacyclodoecane-a,a ,a,"a"-tetramethyl-1 ,4,7, 1 0-tetraacetate (TmDOTMA) for MR thermometry, 2) to develop MR thermometry techniques for reliable, accurate and rapid imaging of temperature using a TmDOTMk complex, 3) to demonstrate feasibility of in vivo monitoring and imaging of temperature during hyperthermia in a mouse tumor model, and 4) to perform a preliminary study on acute effects of hyperthermia on tumor lactate and perfusion. The major advantage of the TmDOTMA is that the proton signals from methyl groups are more intense and sharper compared to the proton signals from TmDOTA. This will greatly help in improving the spatial, temporal and thermal resolution in temperature imaging. TmDOTk and TmDOTMK are expected to be non-toxic because similar complexes of gadolinium are clinically used as MR contrast agents.

描述（由申请人提供）：非侵入性温度计至关重要 区域性热疗作为治疗方式的未来进步。当前的 磁共振（MR）调节方法的分辨率较差 1H水信号对化学位移的依赖性相对较弱 温度。这项研究的主要目的是开发无创的MR 用于可靠，准确的监视和成像的调节方法 使用顺磁性灯笼复合物中的肿瘤温度。 我们的初步数据表明，原型兰烷化的1H化学移位 复合物，thulium-1,4,7,10-TetraazacyClododecane-1，4,7,10-四乙酸 （tmdota），大约对温度更敏感的大约两个级数 水，因此提供了出色的准确性和分辨率。此外， TMDOTA质子移位对顺磁复合浓度不敏感， pH，[Ca2+]或血浆大分子和离子的存在。这将大大 简化使用灯笼络合物进行MR温度测定法的过程 因为已知高温会在组织pH和其他 参数。 该项目的主要目标是：1）研究甲基的使用 TMDOTK的替换类似物，Thulium 1,4,7,1 0-TetraazacyClodoecane-A，A ，a，“ A” - 四甲基-1，4,7，1 0-二乙酸盐（TMDOTMA），用于MR温度法，2）至 开发MR温度计技术，以可靠，准确和快速成像 使用TMDOTMK复合物的温度，3）证明体内可行性 小鼠肿瘤中热疗期间温度的监测和成像 模型和4）对高温的急性影响进行初步研究 在肿瘤和灌注上。 TMDOTMA的主要优点是 与甲基的质子信号相比 来自TMDOTA的质子信号。这将极大地帮助改善空间， 温度成像中的时间和热分辨率。 TMDOTK和TMDOTMK是 预计将无毒，因为临床上类似的gadolinium复合物 用作MR对比剂。