Hypoxia and Consequences: From Molecule to Malady

缺氧及其后果：从分子到疾病

• 批准号: 7539717
• 负责人: Gabriel G Haddad
• 金额: $ 2.8万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-06-15 至 2009-06-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7539717
• 关键词: Academy; California; Cell physiology; Cells; Chairperson; Collaborations; Disease; Disease Progression; Doctor of Philosophy; Electronics; Ensure; Environment; Fostering; Functional disorder; Health; Human; Hypoxia; Industry; Journals; Malignant Neoplasms; Medicine; Molecular; Molecular Biology; Neurodegenerative Disorders; Neurosciences; New York; New York City; Oxygen; Participant; Pediatrics; Physiology; Printing; Pulmonary Hypertension; Range; Research; Research Personnel; Science; Scientist; Sleep Apnea Syndromes; Staging; Therapeutic Intervention; Touch sensation; Universities; Work; abstracting; career; day; interest; medical schools; member; pediatric department; peer; professor; response; symposium

DESCRIPTION (Provided by applicant): The New York Academy of Sciences is planning an important 3-day conference entitled, "Hypoxia and Consequences: From Molecule to Malady." This meeting will be held on March 12-14, 2009 at the New York Academy of Sciences Conference Center in New York City. The Principle Investigator for this conference is Gabriel Haddad, MD, Professor of Pediatrics and Neuroscience and Chairman of the Department of Pediatrics at The University of California, San Diego. Other members of the scientific organizing committee are Navdeep Chandel, PhD, Associate Professor Medicine and Cell / Molecular Biology, Northwestern University, and Chris Peers PhD, Professor of Cellular Physiology, School of Medicine, University of Leeds. This meeting will cover the cellular and molecular mechanisms that underlie both the rapid and delayed response to hypoxia that have profound impact on maintaining normal physiology. Hypoxia touches many aspects of physiology and pathophysiology and in some instances is involved in progression of diseases such as pulmonary hypertension, sleep apnea, cancer and neurodegenerative disease. This interdisciplinary meeting of broad interest will allow for fertile exchange of views, with discussion and presentations on this topic coming from a diverse range of perspectives. The preliminary agenda lists potential participants who are all world-renowned experts in their fields. Many aspects of this work have appeared recently in the foremost scientific journals. Over 3 days, the topics to be discussed include transcriptional responses to hypoxia, oxygen sensing and pathophysiological responses to hypoxia. The breadth of topics covered and the consideration of responses to hypoxia in both health and disease will ensure wide interest and attendance, and will encourage interest in the field from scientists and clinicians at all stages of their careers. The potential scope for therapeutic intervention - already being exploited commercially - will also attract much interest from industry. The meeting will therefore provide an excellent forum for exchange of ideas and information, fostering new collaborations and contributing the advancement of hypoxia research. Furthermore the meeting content will be available to a wider audience via the electronic and print dissemination materials. This meeting will examine the cellular and molecular mechanisms that underlie responses to hypoxia (a low oxygen environment). These responses can have a profound impact in maintaining normal human physiology and, in some instances, progression of diseases such as pulmonary hypertension, sleep apnea, cancer and neurodegenerative disease. The meeting will bring together experts from a variety of different backgrounds and fields to discuss this important unifying theme. (End of Abstract)

描述（由申请人提供）： 纽约科学院正在计划一个重要的为期3天的会议，题为“缺氧和后果：从分子到疾病。“这次会议将于2009年3月12日至14日在纽约市的纽约科学院会议中心举行。本次会议的主要研究者是Gabriel Haddad，医学博士，儿科和神经科学教授，加州大学圣地亚哥分校儿科系主任。科学组委会的其他成员是西北大学医学和细胞/分子生物学副教授Navdeep Chandel博士和利兹大学医学院细胞生理学教授Chris Peers博士。这次会议将涵盖细胞和分子机制，这些机制是对缺氧的快速和延迟反应的基础，对维持正常生理有深远的影响。缺氧涉及生理学和病理生理学的许多方面，并且在某些情况下涉及诸如肺动脉高压、睡眠呼吸暂停、癌症和神经退行性疾病的疾病进展。这一具有广泛意义的跨学科会议将使人们能够从各种不同的角度就这一主题进行讨论和介绍，从而进行丰富的意见交流。初步议程列出了潜在的与会者，他们都是各自领域的世界知名专家。这项工作的许多方面最近出现在最重要的科学期刊上。在3天的时间里，将讨论的主题包括缺氧的转录反应，氧传感和缺氧的病理生理反应。所涵盖的主题的广度和对健康和疾病中缺氧反应的考虑将确保广泛的兴趣和出席率，并将鼓励科学家和临床医生在其职业生涯的各个阶段对该领域的兴趣。治疗干预的潜在范围----已经在商业上得到利用----也将引起工业界的极大兴趣。因此，会议将为交流思想和信息提供一个很好的论坛，促进新的合作，并促进缺氧研究的进步。此外，会议内容将通过电子和印刷传播材料提供给更广泛的受众。本次会议将研究细胞和分子机制，缺氧（低氧环境）的反应。这些反应可以对维持正常的人体生理机能产生深远的影响，并且在某些情况下，对肺动脉高压、睡眠呼吸暂停、癌症和神经退行性疾病等疾病的进展产生深远的影响。会议将汇集来自各种不同背景和领域的专家，讨论这一重要的统一主题。(End摘要）