RISK AND PROTECTIVE FACTORS IN THE DEVELOPMENT OF ASSOCIATED SYMPTOMS IN AUTISM

自闭症相关症状发生的风险和保护因素

• 批准号: 7292338
• 负责人: Annette Estes
• 金额: $ 15.48万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-06 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7292338
• 关键词: 14 year old; Address; Adolescence; Adolescent; Affect; Affective; Age; Aggressive behavior; Alleles; Anxiety; Autistic Disorder; Behavior; Behavior Therapy; COMT gene; Catechol O-Methyltransferase; Child; Chronic; Chronic stress; Clinical; Cognitive; Cohort Studies; Competence; Data Set; Development; Developmental Delay Disorders; Early Intervention; Emotional; Environment; Etiology; Evaluation; Family; Family Process; Follow-Up Studies; Funding; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Goals; Hydrocortisone; Hyperactive behavior; Individual; Intervention; Knowledge; Laboratories; Lead; Life Cycle Stages; Long-Term Effects; Longitudinal Studies; Marital Relationships; Measures; Mediating; Mediator of activation protein; Mental Health; Methods; Modeling; Monoamine Oxidase A; Outcome; Parent-Child Relations; Parents; Pattern; Phenotype; Physiological; Pituitary-Adrenal System; Play; Principal Investigator; Process; Prospective Studies; Psychopathology; Randomized Controlled Trials; Regulation; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Salivary; Sampling; Sampling Studies; Sleep Disorders; Social Development; Stereotyped Behavior; Stress; Symptoms; Testing; Therapeutic Intervention; Time; Toddler; Training; United States National Institutes of Health; Variant; autism spectrum disorder; base; biological adaptation to stress; cohort; depressive symptoms; design; developmental disease; experience; family influence; follow-up; gene environment interaction; genetic risk factor; improved; insight; neural circuit; prevent; programs; promoter; prospective; response; skills; social; social reciprocity; social skills; therapy design

The overall UW ACE theme centers on a comprehensive developmental model of risk, risk processes, symptom emergence, and adaptation in autism spectrum disorder (ASD). According to this model, early autism risk factors (genetic/familial and environmental) lead to risk processes, namely, altered patterns of interaction between the child and his/her environment, which contribute to the abnormal development of neural circuitry and atypical behaviors. This project examines the interaction between genetic and child phenotypic risk factors and family processes in determining outcome in autism. Outcome will be examined not only in terms of core symptoms, but also in terms of associated symptoms, including repetitive and stereotyped behaviors, hyperactivity, and externalizing and internalizing behaviors. These associated symptoms have a significant impact on both the child and family, and are a common focus of therapeutic interventions. As such, there is a pressing need for longitudinal studies to determine risk and protective factors related to the development of associated symptoms. Project V incorporates two longitudinal follow-up studies of children with ASD to address two broad aims. First, in a prospective longitudinal cohort study of children who are transitioning into adolescence, we will investigate the role of genetic, child phenotypic, and family risk and protective factors in development of associated symptoms. Second, in a younger longitudinal cohort, we will conduct a follow-up study of a randomized, controlled trial of early intensive behavioral intervention to examine the long term effects on both core and associated symptoms. We will test hypotheses regarding potential moderators and mediators of long term effects. This proposal directly addresses goals outlined in the NIH Autism Research Matrix, including the evaluation of intervention strategies and the follow-up of early intervention. The identification of risk and protective factors related to long term outcome, including the development of associated symptoms, will yield important insights into autism, and will inform the critical targets for therapeutic intervention for affected children and families.

UW ACE的总体主题围绕着风险、风险流程、 自闭症谱系障碍(ASD)的症状出现和适应。根据这个模型，早期 自闭症风险因素(遗传/家族性和环境)导致风险过程，即 儿童与他/她的环境之间的互动，这导致了儿童的异常发育 神经回路和非典型行为。这个项目考察了基因和孩子之间的相互作用。 决定自闭症预后的表型危险因素和家庭过程。将对结果进行检查 不仅在核心症状方面，而且在相关症状方面，包括重复和 刻板的行为，多动，外化和内化的行为。这些关联 症状对儿童和家庭都有重大影响，也是治疗的共同焦点。 干预措施。因此，迫切需要进行纵向研究，以确定风险和保护措施。 与相关症状发展相关的因素。项目V包括两个纵向后续行动 对自闭症儿童的研究旨在解决两个广泛的目标。首先，在前瞻性纵向队列研究中 正在过渡到青春期的儿童，我们将调查遗传、儿童表型和 相关症状发生的家庭危险因素和保护因素。第二，在更年轻的纵向 队列，我们将对早期强化行为的随机对照试验进行后续研究 干预以检查对核心症状和相关症状的长期影响。我们将测试 关于长期影响的潜在调节因子和调节因子的假设。这项建议直接 解决NIH自闭症研究矩阵中概述的目标，包括对干预的评估 早期干预的策略和后续行动。与之相关的风险识别和保护因素 长期结果，包括相关症状的发展，将产生重要的见解 自闭症，并将为受影响儿童和家庭的治疗干预的重要目标提供信息。