RISK AND PROTECTIVE FACTORS IN THE DEVELOPMENT OF ASSOCIATED SYMPTOMS IN AUTISM

自闭症相关症状发生的风险和保护因素

• 批准号: 8326763
• 负责人: Annette Estes
• 金额: $ 16.81万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8326763
• 关键词: 14 year old; 2 year old; Address; Adolescence; Adolescent; Affect; Affective; Age; Aggressive behavior; Alleles; Anxiety; Autistic Disorder; Behavior; Behavior Therapy; Child; Chronic; Chronic stress; Clinical; Cognitive; Cohort Studies; Competence; Data Set; Development; Developmental Delay Disorders; Early treatment; Emotional; Environment; Etiology; Evaluation; Family; Family Process; Funding; Genes; Genetic; Genetic Polymorphism; Genetic Predisposition to Disease; Goals; Hydrocortisone; Hyperactive behavior; Individual; Intervention; Knowledge; Laboratories; Lead; Life Cycle Stages; Long-Term Effects; Longitudinal Studies; Marital Relationships; Measures; Mediating; Mediator of activation protein; Mental Health; Methods; Modeling; Monoamine Oxidase A; National Institute of Mental Health; Outcome; Outcomes Research; Parent-Child Relations; Parents; Pattern; Phenotype; Physiological; Pituitary-Adrenal System; Play; Principal Investigator; Process; Prospective Studies; Psychopathology; Randomized Controlled Trials; Regulation; Research; Research Design; Research Personnel; Risk; Risk Factors; Role; Salivary; Sampling; Sampling Studies; Sleep Disorders; Social Development; Stereotyped Behavior; Stress; Symptoms; Testing; Therapeutic Intervention; Time; Toddler; Training; United States National Institutes of Health; Variant; autism spectrum disorder; base; biological adaptation to stress; cohort; depressive symptoms; design; developmental disease; experience; family influence; follow-up; gene environment interaction; genetic risk factor; improved; insight; neural circuit; prevent; programs; promoter; prospective; response; skills; social; social reciprocity; social skills; therapy design

The overall UW ACE theme centers on a comprehensive developmental model of risk, risk processes, symptom emergence, and adaptation in autism spectrum disorder (ASD). According to this model, early autism risk factors (genetic/familial and environmental) lead to risk processes, namely, altered patterns of interaction between the child and his/her environment, which contribute to the abnormal development of neural circuitry and atypical behaviors. This project examines the interaction between genetic and child phenotypic risk factors and family processes in determining outcome in autism. Outcome will be examined not only in terms of core symptoms, but also in terms of associated symptoms, including repetitive and stereotyped behaviors, hyperactivity, and externalizing and internalizing behaviors. These associated symptoms have a significant impact on both the child and family, and are a common focus of therapeutic interventions. As such, there is a pressing need for longitudinal studies to determine risk and protective factors related to the development of associated symptoms. Project V incorporates two longitudinal follow-up studies of children with ASD to address two broad aims. First, in a prospective longitudinal cohort study of children who are transitioning into adolescence, we will investigate the role of genetic, child phenotypic, and family risk and protective factors in development of associated symptoms. Second, in a younger longitudinal cohort, we will conduct a follow-up study of a randomized, controlled trial of early intensive behavioral intervention to examine the long term effects on both core and associated symptoms. We will test hypotheses regarding potential moderators and mediators of long term effects. This proposal directly addresses goals outlined in the NIH Autism Research Matrix, including the evaluation of intervention strategies and the follow-up of early intervention. The identification of risk and protective factors related to long term outcome, including the development of associated symptoms, will yield important insights into autism, and will inform the critical targets for therapeutic intervention for affected children and families.

UW ACE的整体主题集中在风险、风险过程、