Identification of biomarkers of response and toxicity to chemoradiotherapy for oesophageal tumours

食管肿瘤放化疗反应和毒性生物标志物的鉴定

• 批准号: nhmrc : 1022720
• 负责人: A/Pr Joanne Bowen
• 金额: $ 33.14万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/identification-biomarkers-response-oesophageal-tumours/110211
• 关键词: Identification; biomarkers; response; toxicity; chemoradiotherapy

Chemoradiotherapy for oesophageal tumours has high interpatient variability in response and toxicity to treatment. Predictive biomarkers of response and toxicity would help select patients who would benefit most from this treatment modality. The proposed project will determine blood-derived microRNA and mRNA profiles that identify patients according to risk of unfavourable treatment outcomes, enabling clinicians to offer personalised alternative treatment strategies for those patients.

食管肿瘤的放化疗在治疗反应和毒性方面具有很高的患者间变异性。反应和毒性的预测性生物标志物将有助于选择从这种治疗方式中获益最多的患者。拟议的项目将确定血液来源的microRNA和mRNA谱，根据不利治疗结果的风险识别患者，使临床医生能够为这些患者提供个性化的替代治疗策略。