CORE--Imaging

核心--成像

• 批准号: 7786050
• 负责人: Louis Dell'ltalia
• 金额: $ 74.05万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7786050
• 关键词: CORE; Imaging

In the current SCCOR, we are attempting to understand the underlying biochemical mechanisms of LV remodeling and, as such, this Core is integral in that it will provide in vivo measurements of LV function and geometry in all SCCOR projects. The state of the art features are brought to bear in both human and animal studies. First, in the human studies we utilize 3-dimensional MR imaging and tissue tagging with state of the art quantitative strain and curvature analysis led by Dr. Denney at Auburn University. This allows for a definitive analysis of changes in geometry and function that is also highly reproducible and, thus, highly amenable to the serial studies. The reproducibility of imaging is crucial for comparisons within and between projects. Therefore, centralization of this and the service it provides are central to the success of the SCCOR. Second, animals will undergo echocardiographic examinations and hemodynamic assessments to obtain LV dimensions, LV end-systolic stress-volume and LV end-diastolic pressure-volume relations. Therefore, centralization of this and the service it provides are central to the success of the SCCOR. One important ultimate goal of Imaging is to generate new insight regarding LV remodeling and function using state of the art three-dimensional magnetic resonance imaging and quantitative strain and curvature analysis that will in turn motivate future novel hypothesis-driven experimental and therapeutic approaches.

在目前的SCCOR中，我们试图了解潜在的生化 LV重塑的机制，因此，这个核心是完整的，因为它将在体内提供 在所有SCCOR项目中测量左室功能和几何形状。最先进的特征在人类和动物研究中都得到了应用。首先，在人体研究中，我们利用三维磁共振成像和最先进的定量应变和组织标记 奥本大学丹尼博士领导的曲率分析。这使得可以对几何和功能的变化进行明确的分析，而且这种分析也具有高度的重复性，因此非常适合于系列研究。成像的重复性对于项目内部和项目之间的比较至关重要。因此，集中化及其提供的服务至关重要 为SCCOR的成功干杯。其次，动物将接受超声心动图检查和血流动力学评估，以获得左心室内径、左心室收缩末期应力-容量和左心室 舒张末压力-容量关系。因此，集中这一点和服务它 提供是SCCOR成功的关键。成像的一个重要终极目标 是利用最先进的技术对左心室重塑和功能产生新的见解 三维磁共振成像和定量应变和曲率分析将反过来激励未来新的假设驱动的实验和治疗方法。