CORE--Imaging

核心--成像

• 批准号: 7786056
• 负责人: Louis Dell'ltalia
• 金额: $ 74.36万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7786056
• 关键词: CORE; Imaging

In the current SCCOR, we are attempting to understand the underlying biochemical mechanisms of LV remodeling and, as such, this Core is integral in that it will provide in vivo measurements of LV function and geometry in all SCCOR projects. The state of the art features are brought to bear in both human and animal studies. First, in the human studies we utilize 3-dimensional MR imaging and tissue tagging with state of the art quantitative strain and curvature analysis led by Dr. Denney at Auburn University. This allows for a definitive analysis of changes in geometry and function that is also highly reproducible and, thus, highly amenable to the serial studies. The reproducibility of imaging is crucial for comparisons within and between projects. Therefore, centralization of this and the service it provides are central to the success of the SCCOR. Second, animals will undergo echocardiographic examinations and hemodynamic assessments to obtain LV dimensions, LV end-systolic stress-volume and LV end-diastolic pressure-volume relations. Therefore, centralization of this and the service it provides are central to the success of the SCCOR. One important ultimate goal of Imaging is to generate new insight regarding LV remodeling and function using state of the art three-dimensional magnetic resonance imaging and quantitative strain and curvature analysis that will in turn motivate future novel hypothesis-driven experimental and therapeutic approaches.

在目前的SCCOR中，我们试图了解潜在的生物化学 因此，该核心是不可或缺的，因为它将在体内提供 所有SCCOR项目中的LV功能和几何结构测量。在人类和动物研究中均采用了最新技术水平的特征。首先，在人体研究中，我们利用三维MR成像和组织标记，具有最先进的定量应变和 由奥本大学的丹尼博士领导的曲率分析。这允许对几何形状和功能的变化进行确定性分析，其也具有高度重现性，因此非常适合于系列研究。成像的可重复性对于项目内部和项目之间的比较至关重要。因此，集中化这一点和它提供的服务是中心 SCCOR的成功。其次，动物将经历超声心动图检查和血液动力学评估以获得LV尺寸、LV收缩末期应力-容积和LV收缩末期压力-容积。 舒张末期压力-容积关系。因此，集中化和服务， 提供服务是SCCOR成功的关键。成像的一个重要最终目标 是利用最新技术水平，产生关于LV重塑和功能的新见解 三维磁共振成像和定量应变和曲率分析，这反过来又会激励未来的新的假设驱动的实验和治疗方法。