权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Enantioselective Applications of Designer Synergic Reagents

设计协同试剂的对映选择性应用

基本信息

批准号：
EP/F065833/1
负责人：
Charles O'Hara
金额：
$ 26.31万
依托单位：
University of Strathclyde
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FF065833%2F1
关键词：
Enantioselective Applications Designer Synergic Reagents

项目摘要

Organo-alkali metal compounds, especially organolithium reagents (that is compounds that contain a direct bond between a lithium atom and a carbon atom) are extremely important synthetic reagents. Indeed, it has been estimated that 98% of all drugs produced by the pharmaceutical industry rely upon the use of these reagents at some point in their synthesis. In general, organolithium compounds are highly reactive; however, this is sometimes coupled with the compounds exhibiting a lack of selectivity. To overcome this situation, less reactive, but more selective compounds (such as organomagnesium reagents) are often used. Recent research has shown that by combining a lithium reagent with a magnesium (or zinc) one, a whole new and in many cases surprising chemistry can be produced. Just as the human body has a left and a right hand, certain organic molecules (commonly known as chiral compounds) which are used to make new drugs can also be considered left or right handed. In medicine, it is common that only one handed form of an organic molecule has the required therapuetic effect; it is also usual that the other handed form induces nasty side effects. It is therefore important that the synthetic chemist can produce only one handed form of a specific organic compound - in chemistry, this is known as enantioselective synthesis.In this research, a detailed systematic investigation of the two aforementioned topics will be combined for the first time - that is enantioselective synthesis using alkali metal-magnesium or alkali metal-zinc complexes. During the first part of this research many new mixed-metal compounds which contain chiral molecules will be synthesised. Various analytical techniques will be used to fully determine the structure - both in solution and in the solid state. Then a full and systematic study of how these compounds react with organic molecules will be conducted.It is envisaged that in the near future these new mixed-metal complexes will be used to complement the well known organolithium reagents in the pharmaceutical industry.

有机碱金属化合物，特别是有机锂试剂（即锂原子和碳原子之间直接键合的化合物）是极其重要的合成试剂。事实上，据估计，制药工业生产的所有药物中有 98% 在合成过程中的某个阶段依赖于这些试剂的使用。一般来说，有机锂化合物具有很高的反应活性；然而，有时这会导致化合物缺乏选择性。为了克服这种情况，通常使用反应性较低但选择性更高的化合物（例如有机镁试剂）。最近的研究表明，通过将锂试剂与镁（或锌）试剂结合，可以产生一种全新的、在许多情况下令人惊讶的化学反应。正如人体有左手和右手一样，用于制造新药的某些有机分子（通常称为手性化合物）也可以被认为是左手或右手。在医学上，通常只有一种有机分子具有所需的治疗效果。另一只手的形式也通常会引起令人讨厌的副作用。因此，重要的是合成化学家只能生产特定有机化合物的单手形式——在化学中，这被称为对映选择性合成。在这项研究中，将首次结合对上述两个主题的详细系统研究——即使用碱金属-镁或碱金属-锌络合物进行对映选择性合成。在这项研究的第一部分中，将合成许多含有手性分子的新型混合金属化合物。将使用各种分析技术来全面确定溶液和固态的结构。然后将对这些化合物如何与有机分子反应进行全面、系统的研究。预计在不久的将来这些新型混合金属配合物将用于补充制药行业中众所周知的有机锂试剂。