BIOSTATISTICS/BIOINFORMATICS

生物统计学/生物信息学

• 批准号: 7414791
• 负责人: PETER D. EMANUEL
• 金额: $ 83.05万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7414791
• 关键词: Advisory Committees; Animals; Bioinformatics; Biometry; Brain; Breast; Cancer Center; Clinical Research; Clinical Trials; Clinical trial protocol document; Communication; Computer software; Consultations; Data; Data Analyses; Data Collection; Databases; Development; Education; Ensure; Gene Expression; Guidelines; Image; Informatics; Interdisciplinary Study; Malignant Neoplasms; Mass Spectrum Analysis; Methodology; Online Systems; Ovarian; Pancreas; Participant; Pathology; Pathway Analysis; Patients; Policies; Procedures; Proteomics; Protocols documentation; Randomized; Reproduction spores; Research Design; Research Methodology; Research Personnel; Research Proposals; Research Support; Resources; Retrieval; Sample Size; Students; System; Systems Analysis; Techniques; Testing; Tissue Banks; Tissue Procurements; Training; United States National Institutes of Health; anticancer research; data management; design; mathematical model; oncology

DESCRIPTION (provided by applicant): The primary objective of the Biostatistics and Bioinformatics Shared Facility (BBSF) is to serve as a focal point from which the Center's investigators may draw statistical and bioinformatic expertise for planning, management and analysis of their studies. The specific aims of the Biostatistics Shared Facility are to: 1) coordinate and manage statistical and bioinformatic activities in the Cancer Center to ensure that investigators have ready access to statistical and bioinformatic consultation and support; 2) provide statistical expertise in study design, including research proposal development; 3) provide data analysis for Cancer Center projects using contemporary statistical and bioinformatic methodologies; 4) maintain the clinical trial protocol and patient registration data management system for the Cancer Center Clinical Studies Unit and further develop protocol specific databases for the Center's clinical trials; 5) develop and manage a comprehensive database for each of the Center's four SPOREs to serve as a multidisciplinary research resource for SPORE investigators; 6) develop and manage web-based data management systems for the Center's Gene Expression and Mass Spectroscopy/Proteomic Shared Facilities; 7) develop and manage image storage, retrieval and analysis system for the Center's Small Animal Image Shared Facility; 8) be an active participant and collaborator of the NCI's Cancer Bioinformatics Grid (caBIG) Initiatives; 9) maintain a computing facility with up-to-date software for data management, data analysis, and network communications; and provide support for the Cancer Center's Data Sharing Plan; 10) perform methodology research in biostatistics and bioinformatics that will enhance the BBSF's technical capabilities and requirements in providing collaborative research support; and 11) provide training opportunities and education in biostatistics and bioinformatics to graduate students, oncology residents, fellows and Cancer Center investigators. The BBSF will be operated under the specific usage policies and priority guidelines established with the advise of its Advisory Committee.

描述（由申请人提供）：生物统计学和生物信息学共享设施（BBSF）的主要目标是作为一个焦点，中心的研究人员可以从中汲取统计和生物信息学专业知识，以计划，管理和分析其研究。 生物统计学共享设施的具体目的是：1）协调和管理癌症中心中的统计和生物信息学活动，以确保调查人员可以随时获得统计和生物信息咨询和支持； 2）提供研究设计方面的统计专业知识，包括研究建议开发； 3）使用当代统计和生物信息学方法来为癌症中心项目提供数据分析； 4）维护癌症中心临床研究部门的临床试验方案和患者注册数据管理系统，并进一步为中心的临床试验开发特定的数据库； 5）开发和管理 该中心的四个孢子中的每个孢子中的每个综合数据库，可作为孢子研究人员的多学科研究资源； 6）为中心的基因表达和质谱/蛋白质组学共享设施开发和管理基于Web的数据管理系统； 7）为中心的小动物图像共享设施开发和管理图像存储，检索和分析系统； 8）成为NCI癌症生物信息学网格（CABIG）计划的积极参与者和合作者； 9）维护具有用于数据管理，数据分析和网络通信的最新软件的计算设施；并为癌症中心的数据共享计划提供支持； 10）在生物统计学和生物信息学方面进行方法研究，以增强BBSF在提供协作研究支持方面的技术能力和要求； 11）为研究生，肿瘤学居民，研究员和癌症中心调查人员提供生物统计学和生物信息学方面的培训机会和教育。 BBSF将根据特定 在其咨询委员会的建议下制定的使用政策和优先指南。