TISSUE PROCUREMENT

描述(由申请人提供)：UAB在收集、处理、 储存和供应广泛的人体组织，以支持癌症研究。肿瘤组织和对照组织作为新鲜、冷冻和石蜡处理的标本提供，组织切片和其他组织学服务应设施用户的要求提供。要求组织切片代替其他组织形式的研究人员数量继续增加。在目前的筹资期间，我们通过提供显微解剖标本和构建组织阵列扩大了我们的服务。目前，组织被收集并在被要求时提供给研究人员，我们没有维持一个活跃的肿瘤库。在UAB相关医院获得的组织被组织采购人员冰冻转移到外科病理学，在那里获得了不需要诊断的多余组织。与UAB组织采购共享设施相关的外科病理学家评估为研究提供的所有组织的等量质量和诊断准确性。根据我们在上一个供资期间的经验，我们预计该基金将继续在促进综合癌症中心的目标方面发挥非常积极的作用，特别是在促进在基础和转译研究中有效使用新方法、协调临床试验中的人体组织利用以及确保 不断变化的监管环境。该设施满足这些需求的能力得到了最近的翻修以及工作人员不断参与组织加工和银行领域的教育计划和积极研究的保证。UAB参与开发了一个全面的数据库和条形码系统，通过纳入有关组织捐赠者、组织诊断和质量的信息来支持组织资源 控制、组织加工和储存、研究人员对组织的需求和研究人员对组织的使用。2003年3月至2004年2月，该设施向83名UAB调查人员提供了3437份新鲜或冷冻的人体组织样本、1174块石蜡和6779张幻灯片。自1978年以来，我们的设施已经向UAB的300多名研究人员提供了大约72,779份组织标本、块和玻片。这些纸巾已经在总共893份出版物中使用。

DESCRIPTION (provided by applicant): UAB has extensive experience in collecting, processing, storing, and supplying a wide range of human tissues to support research in cancer. Neoplastic and control tissues are supplied as fresh, frozen, and paraffin-processed specimens and tissue sections and other histology services are provided as requested by the users of the facility. The number of investigators requesting tissue sections in lieu of other forms of tissue continues to grow. We have expanded our service during the current funding period by offering microdissected specimens and the construction of tissue arrays. Currently tissues are collected and supplied to investigators when requested and we do not maintain an active tumor bank. Tissues obtained at the UAB-associated hospitals are transferred on ice by the Tissue Procurement personnel to surgical pathology where excess tissues not required for diagnosis are obtained. Surgical pathologists associated with the UAB Tissue Procurement Shared Facility evaluate aliquots of all tissues supplied for research for quality and diagnostic accuracy. Based on our experience in the previous funding period, we anticipate that the Facility will continue to play a very active role in promoting the goals of the Comprehensive Cancer Center most especially in enabling the effective use of emerging methodologies in basic and translational research, coordinating human tissue utilization in clinical trials, and ensuring compliance in the changing regulatory environment. The ability of the facility to meet these demands is assured by recent renovations and the ongoing participation of the staff in educational programs and active research in the area of tissue processing and banking. UAB has participated in the development of a comprehensive database and bar coding system that supports tissue resources by incorporating information on the tissue donor, tissue diagnosis and quality control, tissue processing and storage, investigator tissue requirements and usage of the tissues by researchers. Between March 2003 and February 2004, the facility provided 83 UAB investigators with 3437 fresh or frozen human tissue samples, 1174 paraffin blocks, and 6779 slides. Since 1978, our facility has provided approximately 72,779 tissue specimens, blocks, and slides to over 300 investigators at UAB. These tissues have been used in a total of 893 publications.