TISSUE PROCUREMENT

纸巾采购

• 批准号: 7414792
• 负责人: PETER D. EMANUEL
• 金额: $ 21.37万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7414792
• 关键词: Aliquot; Area; Arts; Biological Assay; Cancer Center; Clinical Protocols; Clinical Trials; Code; Collection; Comprehensive Cancer Center; Computer software; Consultations; Continuing Education; Cooperative Human Tissue Network; Data; Databases; Development; Diagnosis; Diagnostic; Ensure; Environment; Facility Construction Funding Category; Faculty; Freezing; Frozen Sections; Funding; Funding Agency; Future; Goals; Health Insurance Portability and Accountability Act; Histology; Hospitals; Human; Human Resources; Ice; Informed Consent; Liquid substance; Malignant - descriptor; Malignant Neoplasms; Medical; Methodology; Molecular; Monitor; Numbers; Operative Surgical Procedures; Paraffin; Pathologist; Patients; Plasma; Play; Privacy; Procedures; Process; Protocols documentation; Publications; Quality Control; Range; Regulation; Research; Research Ethics Committees; Research Personnel; Research Project Grants; Role; Services; Site; Slide; Social Welfare; Solid; Source; Specimen; Specimen Handling; Staining method; Stains; Support of Research; Surgical Pathology; Tissue Banks; Tissue Donors; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Bank; University of Alabama at Birmingham Cancer Center; Update; anticancer research; base; design; diagnosis quality; diagnostic accuracy; experience; human tissue; laser capture microdissection; neoplastic; programs; tissue processing; tissue resource; tumor

DESCRIPTION (provided by applicant): UAB has extensive experience in collecting, processing, storing, and supplying a wide range of human tissues to support research in cancer. Neoplastic and control tissues are supplied as fresh, frozen, and paraffin-processed specimens and tissue sections and other histology services are provided as requested by the users of the facility. The number of investigators requesting tissue sections in lieu of other forms of tissue continues to grow. We have expanded our service during the current funding period by offering microdissected specimens and the construction of tissue arrays. Currently tissues are collected and supplied to investigators when requested and we do not maintain an active tumor bank. Tissues obtained at the UAB-associated hospitals are transferred on ice by the Tissue Procurement personnel to surgical pathology where excess tissues not required for diagnosis are obtained. Surgical pathologists associated with the UAB Tissue Procurement Shared Facility evaluate aliquots of all tissues supplied for research for quality and diagnostic accuracy. Based on our experience in the previous funding period, we anticipate that the Facility will continue to play a very active role in promoting the goals of the Comprehensive Cancer Center most especially in enabling the effective use of emerging methodologies in basic and translational research, coordinating human tissue utilization in clinical trials, and ensuring compliance in the changing regulatory environment. The ability of the facility to meet these demands is assured by recent renovations and the ongoing participation of the staff in educational programs and active research in the area of tissue processing and banking. UAB has participated in the development of a comprehensive database and bar coding system that supports tissue resources by incorporating information on the tissue donor, tissue diagnosis and quality control, tissue processing and storage, investigator tissue requirements and usage of the tissues by researchers. Between March 2003 and February 2004, the facility provided 83 UAB investigators with 3437 fresh or frozen human tissue samples, 1174 paraffin blocks, and 6779 slides. Since 1978, our facility has provided approximately 72,779 tissue specimens, blocks, and slides to over 300 investigators at UAB. These tissues have been used in a total of 893 publications.

描述（申请人提供）：UAB在收集，处理，具有丰富的经验 存储并提供广泛的人体组织来支持癌症的研究。 根据设施的用户要求提供肿瘤和控制组织，作为新鲜，冷冻和石蜡处理的标本和组织切片以及其他组织学服务。 要求组织切片以代替其他形式组织的研究人员的数量继续增加。 在当前的融资期间，我们通过提供微解码标本和构造组织阵列来扩大服务。 目前，在要求时收集组织并提供给研究人员，并且我们不维护活跃的肿瘤库。 在UAB相关医院获得的组织在组织采购人员在冰上转移到手术病理学上，其中获得了诊断不需要的多余组织。 与UAB组织采购相关的外科病理学家共享设施评估提供的所有组织的等分试样，以进行质量和诊断准确性。 根据我们在上一期资金期间的经验，我们预计该设施将继续在促进综合癌症中心的目标中发挥非常积极的作用，尤其是在实现基本和转化研究中有效利用新兴方法，并协调人类组织在临床试验中的合规性，并确保 不断变化的监管环境。 最近的翻新以及员工参与教育计划和组织加工和银行业领域的积极研究，确保了该设施满足这些要求的能力。 UAB参与了通过合并有关组织供体，组织诊断和质量信息来支持组织资源的综合数据库和条形码系统的开发 研究人员对控制，组织加工和存储，研究者组织需求以及组织使用。 在2003年3月至2004年2月之间，该设施为83名UAB研究人员提供了3437个新鲜或冷冻的人体组织样品，1174个石蜡块和6779张幻灯片。 自1978年以来，我们的设施为UAB的300多名研究人员提供了大约72,779个组织标本，块和幻灯片。 这些组织已在总共893个出版物中使用。