TISSUE PROCUREMENT

描述（由申请人提供）：UAB在收集，处理， 储存和提供各种人体组织，以支持癌症研究。 肿瘤和对照组织以新鲜、冷冻和石蜡处理的标本和组织切片形式提供，并根据设施用户的要求提供其他组织学服务。 要求用组织切片代替其他形式组织的调查员人数继续增加。 在当前的资助期内，我们通过提供显微解剖标本和组织阵列的构建扩大了我们的服务。 目前，组织是在需要时收集并提供给研究者的，我们没有维持一个活跃的肿瘤库。 在UAB相关医院获得的组织由组织采购人员在冰上转移到外科病理学，在那里获得诊断不需要的多余组织。 与UAB组织采购共享机构相关的外科病理学家对提供用于研究的所有组织的等分试样进行质量和诊断准确性评估。 根据我们在上一个资助期的经验，我们预计该基金将继续在促进综合癌症中心的目标方面发挥非常积极的作用，特别是在基础和转化研究中有效利用新兴方法，协调临床试验中的人体组织利用，并确保遵守 不断变化的监管环境。 最近的翻修和工作人员持续参与教育计划以及组织处理和银行领域的积极研究，确保了该设施满足这些需求的能力。UAB参与了一个综合数据库和条形码系统的开发，该系统通过整合组织供体、组织诊断和质量信息来支持组织资源。 控制、组织处理和储存、研究者组织要求和研究者对组织的使用。 在2003年3月至2004年2月期间，该机构向83名UAB研究者提供了3437份新鲜或冷冻人体组织样本、1174个石蜡块和6779个载玻片。 自1978年以来，我们的机构已向UAB的300多名研究人员提供了约72，779份组织标本、组织块和载玻片。 这些组织已在共计893篇出版物中使用。

DESCRIPTION (provided by applicant): UAB has extensive experience in collecting, processing, storing, and supplying a wide range of human tissues to support research in cancer. Neoplastic and control tissues are supplied as fresh, frozen, and paraffin-processed specimens and tissue sections and other histology services are provided as requested by the users of the facility. The number of investigators requesting tissue sections in lieu of other forms of tissue continues to grow. We have expanded our service during the current funding period by offering microdissected specimens and the construction of tissue arrays. Currently tissues are collected and supplied to investigators when requested and we do not maintain an active tumor bank. Tissues obtained at the UAB-associated hospitals are transferred on ice by the Tissue Procurement personnel to surgical pathology where excess tissues not required for diagnosis are obtained. Surgical pathologists associated with the UAB Tissue Procurement Shared Facility evaluate aliquots of all tissues supplied for research for quality and diagnostic accuracy. Based on our experience in the previous funding period, we anticipate that the Facility will continue to play a very active role in promoting the goals of the Comprehensive Cancer Center most especially in enabling the effective use of emerging methodologies in basic and translational research, coordinating human tissue utilization in clinical trials, and ensuring compliance in the changing regulatory environment. The ability of the facility to meet these demands is assured by recent renovations and the ongoing participation of the staff in educational programs and active research in the area of tissue processing and banking. UAB has participated in the development of a comprehensive database and bar coding system that supports tissue resources by incorporating information on the tissue donor, tissue diagnosis and quality control, tissue processing and storage, investigator tissue requirements and usage of the tissues by researchers. Between March 2003 and February 2004, the facility provided 83 UAB investigators with 3437 fresh or frozen human tissue samples, 1174 paraffin blocks, and 6779 slides. Since 1978, our facility has provided approximately 72,779 tissue specimens, blocks, and slides to over 300 investigators at UAB. These tissues have been used in a total of 893 publications.