TISSUE PROCUREMENT

纸巾采购

• 批准号: 7414792
• 负责人: PETER D. EMANUEL
• 金额: $ 21.37万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7414792
• 关键词: Aliquot; Area; Arts; Biological Assay; Cancer Center; Clinical Protocols; Clinical Trials; Code; Collection; Comprehensive Cancer Center; Computer software; Consultations; Continuing Education; Cooperative Human Tissue Network; Data; Databases; Development; Diagnosis; Diagnostic; Ensure; Environment; Facility Construction Funding Category; Faculty; Freezing; Frozen Sections; Funding; Funding Agency; Future; Goals; Health Insurance Portability and Accountability Act; Histology; Hospitals; Human; Human Resources; Ice; Informed Consent; Liquid substance; Malignant - descriptor; Malignant Neoplasms; Medical; Methodology; Molecular; Monitor; Numbers; Operative Surgical Procedures; Paraffin; Pathologist; Patients; Plasma; Play; Privacy; Procedures; Process; Protocols documentation; Publications; Quality Control; Range; Regulation; Research; Research Ethics Committees; Research Personnel; Research Project Grants; Role; Services; Site; Slide; Social Welfare; Solid; Source; Specimen; Specimen Handling; Staining method; Stains; Support of Research; Surgical Pathology; Tissue Banks; Tissue Donors; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Translational Research; Tumor Bank; University of Alabama at Birmingham Cancer Center; Update; anticancer research; base; design; diagnosis quality; diagnostic accuracy; experience; human tissue; laser capture microdissection; neoplastic; programs; tissue processing; tissue resource; tumor

DESCRIPTION (provided by applicant): UAB has extensive experience in collecting, processing, storing, and supplying a wide range of human tissues to support research in cancer. Neoplastic and control tissues are supplied as fresh, frozen, and paraffin-processed specimens and tissue sections and other histology services are provided as requested by the users of the facility. The number of investigators requesting tissue sections in lieu of other forms of tissue continues to grow. We have expanded our service during the current funding period by offering microdissected specimens and the construction of tissue arrays. Currently tissues are collected and supplied to investigators when requested and we do not maintain an active tumor bank. Tissues obtained at the UAB-associated hospitals are transferred on ice by the Tissue Procurement personnel to surgical pathology where excess tissues not required for diagnosis are obtained. Surgical pathologists associated with the UAB Tissue Procurement Shared Facility evaluate aliquots of all tissues supplied for research for quality and diagnostic accuracy. Based on our experience in the previous funding period, we anticipate that the Facility will continue to play a very active role in promoting the goals of the Comprehensive Cancer Center most especially in enabling the effective use of emerging methodologies in basic and translational research, coordinating human tissue utilization in clinical trials, and ensuring compliance in the changing regulatory environment. The ability of the facility to meet these demands is assured by recent renovations and the ongoing participation of the staff in educational programs and active research in the area of tissue processing and banking. UAB has participated in the development of a comprehensive database and bar coding system that supports tissue resources by incorporating information on the tissue donor, tissue diagnosis and quality control, tissue processing and storage, investigator tissue requirements and usage of the tissues by researchers. Between March 2003 and February 2004, the facility provided 83 UAB investigators with 3437 fresh or frozen human tissue samples, 1174 paraffin blocks, and 6779 slides. Since 1978, our facility has provided approximately 72,779 tissue specimens, blocks, and slides to over 300 investigators at UAB. These tissues have been used in a total of 893 publications.

描述（由申请人提供）：UAB 在收集、处理、 储存和供应各种人体组织以支持癌症研究。 肿瘤组织和对照组织以新鲜、冷冻和石蜡处理的标本和组织切片的形式提供，并根据设施用户的要求提供其他组织学服务。 要求用组织切片代替其他形式组织的研究人员数量持续增长。 在当前资助期间，我们通过提供显微解剖标本和组织阵列的构建扩大了我们的服务。 目前，我们会根据要求收集组织并提供给研究人员，但我们没有维持活跃的肿瘤库。 从 UAB 附属医院获得的组织由组织采购人员在冰上转移到外科病理科，在那里获得诊断不需要的多余组织。 与 UAB 组织采购共享设施相关的外科病理学家评估用于研究的所有组织的等分试样的质量和诊断准确性。 根据我们在上一个资助期间的经验，我们预计该基金将继续在促进综合癌症中心的目标方面发挥非常积极的作用，尤其是在基础和转化研究中有效利用新兴方法、协调临床试验中的人体组织利用以及确保临床试验中的合规性方面。 不断变化的监管环境。 最近的翻修以及工作人员持续参与组织加工和银行领域的教育计划和积极研究，保证了该设施满足这些需求的能力。 UAB 参与了综合数据库和条形码系统的开发，该系统通过整合有关组织供体、组织诊断和质量的信息来支持组织资源 控制、组织处理和储存、研究者组织要求以及研究人员对组织的使用。 2003年3月至2004年2月期间，该机构向83名UAB研究人员提供了3437份新鲜或冷冻人体组织样本、1174块石蜡块和6779张载玻片。 自 1978 年以来，我们的机构已向 UAB 的 300 多名研究人员提供了大约 72,779 份组织标本、块和玻片。 这些组织已在总共 893 种出版物中使用。