UNC Center for AIDS Research

描述（由申请人提供）：该协会是一个由三个互补机构组成的联盟：北查佩尔山、国际家庭健康组织（FHI）和三角研究所（RTI）。在过去的七年中，我们的CFAR已经发展到满足我们成员的各种需求，并在机构内提供领导。在这次更新申请中，我们建议继续使用我们以前的七个核心，并增加两个新的核心：免疫学核心和国际核心。随着成功的更新，我们将大大增加机构的支持，包括新的指定，连续的空间和新的教师插槽的分配。此外，我们将利用CFAR的资金建立一个资源库，可以用来促进进一步雇用艾滋病毒/艾滋病研究人员。我们的CFAR在制定真实的识别急性艾滋病毒感染的战略方面发挥了核心作用，我们现在与北卡罗来纳州合作，识别这些人并将他们纳入研究方案。在CFAR的支持和领导下，我们已经概念化了新的治疗策略，以改变这些人的疾病进程，我们将在这些领域进行临床试验。我们的艾滋病毒/艾滋病研究中心对国际环境下的艾滋病毒/艾滋病研究作出了重大承诺，新的国际核心将为这一努力提供更有效的支持。我们的CFAR成员已经成功地将HIV候选疫苗带入人体试验，我们新的免疫学核心代表了为其他正在进行的疫苗和临床免疫学研究提供更广泛支持的努力。我们坚定地致力于支持转化研究，我们的三个核心保持CLIA批准，同时与临床核心密切合作。最后，我们已经扩大了我们的发展核心的使用，包括推广和指导，包括艾滋病毒/艾滋病研究人员在历史上少数民族大学在北卡罗来纳州作为潜在的发展获奖者。有了这个，我们的第二次更新，我们的CFAR正在与一个良好的协调领导，积极促进和支持跨学科研究集中在一些关键的研究领域。CFAR的支持对于维持为最大限度地发挥CFAR成员的潜力而签署的这一努力至关重要。

DESCRIPTION (provided by applicant): The UNC CFAR is a consortium of three complementary institutions: UNC Chapel Hill, Family Health International (FHI), and Research Triangle Institute (RTI). Over the last seven years our CFAR has grown to serve the diverse needs of our membership and to provide leadership within the institutions. In this renewal application we propose to continue with our previous seven cores and to add two new cores: an Immunology Core and an International Core. With a successful renewal we will greatly increase the institutional support, including new designated, contiguous space and the allocation of new faculty slots. In addition, we will use CFAR funding to create a pool of resources that can be leveraged to promote further hiring of HIV/AIDS researchers. Our CFAR has played a central role in the development of a strategy to identify acute HIV infections in real time, and we now partner with the State of North Carolina to identify such people and enroll them into research protocols. With CFAR support and leadership we have conceptualized new therapeutic strategies to alter the course of the disease in these people, and we will pursue clinical trials in these areas. Our CFAR has a substantial commitment to HIV/AIDS research in the international setting and the new International Core will allow more effective support for that effort. Members of our CFAR have successfully brought an HIV vaccine candidate to human trials, and our new Immunology Core represents an effort to bring broader support to other ongoing vaccine and clinical immunology studies. We have a strong commitment to supporting translational research, with three of our cores maintaining CLIA approval while working closely with the Clinical Core. Finally, we have extended the use of our Developmental Core to include outreach and mentoring by including HIV/AIDS researchers at historically minority universities across North Carolina as potential Developmental Awardees. With this, our second renewal, our CFAR is functioning with a well coordinated leadership that is actively promoting and supporting interdisciplinary research focused on a number of critical research areas. CFAR support is essential to maintain this effort signed to maximize the potential of the CFAR membership.