UNC Center for AIDS Research Core C Clinical

北卡罗来纳大学艾滋病研究中心核心 C 临床

• 批准号: 10404030
• 负责人: Joseph J Eron
• 金额: $ 31.23万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-20 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404030
• 关键词: AIDS clinical trial group; AIDS prevention; Acquired Immunodeficiency Syndrome; Basic Science; Biological; Biopsy; Blood; Censuses; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials Network; Cohort Studies; Collaborations; Collection; Communities; Computerized Medical Record; Data; Data Collection; Data Reporting; Data Sources; Data Storage and Retrieval; Environment; Epidemic; Epidemiology; Evaluation; Fostering; Foundations; Funding; Grant; Growth; HIV; HIV Vaccine Trials Network; Human immunodeficiency virus test; Infrastructure; Interest Group; International; Intervention; Intervention Trial; K-Series Research Career Programs; Laboratories; Leadership; Manuscripts; Mentors; Mentorship; Methods; Mission; Morbidity - disease rate; North Carolina; Observational Study; Organ; Outcome; Paper; Participant; Pathogenesis; Patient Outcomes Assessments; Patient Recruitments; Patients; Performance; Persons; Policies; Positioning Attribute; Postdoctoral Fellow; Prevention; Procedures; Process; Productivity; Public Health; Ramp; Randomized; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Priority; Research Support; Resources; Risk; Sampling; Science; Seeds; Services; Site; Social Behavior; Specimen; Standardization; Strategic Planning; Structure; Students; Surveys; System; Technology; Thinking; Time; Tissues; Training; Translational Research; United States National Institutes of Health; Universities; Work; adjudicate; base; clinical care; clinical epidemiology; clinical research site; clinical trial implementation; cohort; comparative; cost effective; cost efficient; data management; data resource; database design; experience; faculty mentor; improved; innovation; meetings; mortality; novel; outreach; patient population; programs; prospective; protocol development; public health research; recruit; reproductive tract; response; sample collection; skills; translational study; transmission process; web-enabled; working group

PROJECT SUMMARY/ABSTRACT – CLINICAL CORE (CORE C) The UNC CFAR Clinical Core’s mission is to provide services and resources, centered on people living with and at risk for HIV, to foster dynamic and innovative clinical and translational HIV research at UNC Chapel Hill, FHI 360 and RTI. The Core, led by Drs. Joseph Eron, Sonia Napravnik, and Claire Farel, is positioned to respond to key emerging questions in HIV prevention, transmission, treatment, and pathogenesis in a region with high HIV burden, morbidity, and mortality. Experienced leadership and close relationships with laboratory, clinical, and public health research locally, nationally, and internationally create a diverse and robust resource. The Core sustains the comprehensive and longstanding UNC CFAR HIV Clinical Cohort (UCHCC), with partnerships in national and international HIV cohort collaborations, including CNICS, NA-ACCORD and IeDEA. The UCHCC integrates real-time electronic medical records, with routine and standardized clinical record reviews, validated and adjudicated clinical outcome ascertainments, and longitudinally collected biological specimens, augmented by HIV sequence data, socio-behavioral surveys, patient reported outcomes, geospatial data, and state and federally available data (e.g., HIV testing, mortality, US Census). The UCHCC supports research that capitalizes on UNC’s fertile academic environment, enduring partnerships with state public health leadership, and international clinical and research sites. The Core infrastructure includes a full time clinic-embedded screener to recruit participants with and at risk for HIV from our well-characterized patient populations. Our study coordinator, regulatory and research team, support protocol development and implementation, including prospective collection of a broad range of samples, such as blood, CSF, gut and organ biopsies, and genital tract secretions and tissue, enhancing clinical and translational research, and investigator productivity. We also provide web- enabled tracking and data entry systems, database design and support for data management. Integration of the Core within the larger UNC, RTI, and FHI 360 communities fosters opportunities to engage and mentor trainees and early stage investigators, using the Core’s data, specimens and resources. The Core supports NIH networks, including ACTG, HPTN, MACS/WIHS, and Ending the HIV Epidemic through recruitment efforts, data provision, expertise and leadership in these groups. Our value-added, cost-effective and unique services and resources support over 70 investigators annually with basic laboratory science, translational, clinical, epidemiology and public health research, with over 40 OAR FRB investigators and over 500 papers supported in this funding cycle. The Core is committed to innovation in improving and expanding services, to ongoing excellence and growth in acquisition and use of specimens, extension and enrichment of data resources, enhancing outreach to early stage and international investigators, and novel seed funding provision through intra-CFAR Core collaboration. The Clinical Core’s synergistic partnerships with CFAR SWGs, other UNC CFAR Cores, national CFARs and NIH networks and programs advance and stimulate far-reaching innovations in HIV research and science.

项目总结/摘要-临床核心（核心C） 该中心的临床核心的使命是提供服务和资源，集中在人们的生活， 艾滋病毒的风险，以促进动态和创新的临床和转化艾滋病毒研究在圣查佩尔山，FHI 360和RTI。核心，由约瑟夫·埃隆博士，索尼娅·纳普拉夫尼克和克莱尔·法雷尔领导，定位于应对 艾滋病毒高感染率地区艾滋病毒预防、传播、治疗和发病机制方面新出现的关键问题 负担、发病率和死亡率。经验丰富的领导和与实验室，临床和 地方、国家和国际的公共卫生研究创造了多样化和强大的资源。核心 维持全面和长期的艾滋病毒临床队列（UCHCC），与合作伙伴关系， 国家和国际艾滋病毒队列合作，包括CNICS、NA-ACCORD和IeDEA。UCHCC 将实时电子医疗记录与常规和标准化的临床记录审查相结合， 和裁定的临床结局确定，以及纵向收集的生物标本， 艾滋病毒序列数据，社会行为调查，病人报告的结果，地理空间数据，国家和 联邦可用数据（例如，HIV检测、死亡率、美国人口普查）。UCHCC支持研究， 在威斯康星州肥沃的学术环境，与国家公共卫生领导的持久伙伴关系， 国际临床和研究中心。核心基础设施包括一个全职的诊所嵌入式筛选器， 从我们特征明确的患者人群中招募HIV感染者和高危人群。我们的研究协调员， 监管和研究团队，支持方案制定和实施，包括前瞻性 收集广泛的样本，如血液、CSF、肠道和器官活检以及生殖道分泌物 和组织，提高临床和转化研究，以及研究者的生产力。我们还提供Web- 启用跟踪和数据输入系统、数据库设计和数据管理支持。融合 在更大的社区，RTI和FHI 360社区内的核心促进了参与和指导学员的机会 和早期研究人员，使用核心的数据，标本和资源。核心支持NIH网络， 包括ACTG，HPTN，MACS/WIHS，通过招募工作，数据提供， 在这些团体中的专业知识和领导能力。我们的增值、具成本效益和独特的服务和资源 每年为70多名研究人员提供基础实验室科学、转化、临床、流行病学和 公共卫生研究，有40多名OAR FRB调查员和500多篇论文在此资助周期中得到支持。 核心致力于创新，以改善和扩大服务，以持续的卓越和增长， 采集和使用标本，扩大和丰富数据资源，加强对早期 阶段和国际调查人员，并通过CFAR核心内部合作提供新的种子资金。 临床核心与CFAR SWG、其他国家CFAR核心、国家CFAR和 NIH的网络和项目推动并激励了艾滋病研究和科学领域的深远创新。